Bridgett Knox

This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.

Researcher

NCTR

Also affiliated: Qingdao University (2020); United States Food and Drug Administration (2015–2025)

Faculty Researcher

12 h-index 17 pubs 418 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group

OverviewAI-generated summary

Bridgett Knox's research focuses on the pharmacological effects of drugs and their mechanisms of action, particularly involving microRNA regulation. Her work investigates how substances like ketoconazole can suppress steroidogenesis through CYP17A1 inhibition, with a potential role for microRNAs in these processes. Knox also explores the application of microphysiological systems as an in vitro method for evaluating drug absorption, distribution, metabolism, excretion, and toxicity. She has published 17 papers with 416 citations and an h-index of 12. Key collaborators include Dongying Li and Baitang Ning, with whom she shares multiple publications.

Metrics

h-index: 12
Publications: 17
Citations: 418

Selected Publications

SARS-CoV-2 Spike Protein’s Structural Dynamics Affect the Activity of the Bebtelovimab Antibody (2026)

Journal of Chemical Information and Modeling DOI OpenAlex
Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity (2025)

Drug Metabolism and Disposition 8 citations DOI OpenAlex
Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation (2023)

Journal of Pharmacology and Experimental Therapeutics 1 citation DOI OpenAlex
Identification of Translational microRNA Biomarker Candidates for Ketoconazole-Induced Liver Injury Using Next-Generation Sequencing (2020)

Toxicological Sciences 15 citations DOI OpenAlex
Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells (2020)

Archives of Toxicology 23 citations DOI OpenAlex
Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells (2020)

Drug Metabolism and Disposition 10 citations DOI OpenAlex
FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA (2020)

Methods in molecular biology 18 citations DOI OpenAlex
MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation (2019)

Biochemical Pharmacology 21 citations DOI OpenAlex
A functional SNP in the 3′‐UTR of TAP2 gene interacts with microRNA hsa‐miR‐1270 to suppress the gene expression (2017)

Environmental and Molecular Mutagenesis 37 citations DOI OpenAlex
Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans (2017)

Archives of Toxicology 64 citations DOI OpenAlex
The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p (2017)

Biochemical Pharmacology 52 citations DOI OpenAlex
MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation (2017)

Biochemical Pharmacology 62 citations DOI OpenAlex
Systems view of adipogenesis via novel omics-driven and tissue-specific activity scoring of network functional modules (2016)

Scientific Reports 20 citations DOI OpenAlex
MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes (2016)

Biochemical Pharmacology 50 citations DOI OpenAlex
Modulation of ALDH5A1 and SLC22A7 by microRNA hsa-miR-29a-3p in human liver cells (2015)

Biochemical Pharmacology 24 citations DOI OpenAlex