Lei Guo
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Biologist
Also affiliated: Qingdao University (2020–2025); Brigham and Women's Hospital (2000–2008); United States Food and Drug Administration (2005–2026); Université de Sherbrooke (2002); Kyushu University (1995–2000); Harvard University (2000–2014); North China University of Science and Technology (2024); Shandong University (2025); University of Alberta (2001–2008); Canadian Institutes of Health Research (2001–2004); Baylor College of Medicine (2021); Oita University (1998); Chinese Academy of Medical Sciences & Peking Union Medical College (2023); Ningxia University (2024); Fudan University (2018); Tianjin Medical University General Hospital (2015); Chinese PLA General Hospital (2019); Yale University (2008); Tokyo Metropolitan Institute of Medical Science (1994); Peking University People's Hospital (2022–2024); Duke Medical Center (2021); University of Kansas Medical Center (2021); The Affiliated Yongchuan Hospital of Chongqing Medical University (2013); Cancer Hospital of Chinese Academy of Medical Sciences (2023); Tianjin Medical University (2015); Shandong Agricultural University (2022); The University of Tokyo (1999–2000); Zhejiang University (2005); The University of Texas Southwestern Medical Center (2026); Stanford University (2014)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Lei Guo's research focuses on the application and interpretation of high-throughput genomic technologies in toxicological studies. Guo has been involved in significant multi-center projects, including the MicroArray Quality Control (MAQC) project and the Sequencing Quality Control (SQC) Consortium, which aimed to assess and improve the reproducibility and accuracy of gene expression measurements across different platforms and laboratories. These projects have generated guidelines and best practices for the use of these technologies in research and regulatory settings.
Guo's work has explored transcriptomic analyses in various biological models, including rat and mouse studies, to understand gene expression patterns in response to different conditions and exposures. This includes investigations into mechanisms such as autophagy and the effects of specific compounds like minocycline in disease models. The research has also addressed challenges and promises of next-generation sequencing in clinical applications and the interpretation of large-scale gene expression data, emphasizing analytical consistency and the balance of sensitivity and specificity in identifying differentially expressed genes.
With a high-impact researcher designation, Guo has contributed extensively to the field, evidenced by 203 publications and over 18,000 citations. Key collaborators include Si Chen, Xilin Li, Yuxi Li, and Nan Mei, all from the National Center for Toxicological Research, with whom Guo has co-authored numerous publications, indicating a sustained collaborative effort in toxicological research.
Metrics
- h-index: 52
- Publications: 193
- Citations: 18,227
Positions
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Research Biologist 2003–presentNational Center for Toxicological Research ORCID
Selected Publications
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Corrigendum to “Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver” [J. Pharm. Biomed. Anal. 265 (2025) 117034] (2026)
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Translating in vitro mechanistic findings to in vivo toxicity outcomes: A case study of Usnic acid hepatotoxicity (2026)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin in vivo (2025)
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Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver (2025)
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025)
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Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025)
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Investigation of cannabidiol-induced cytotoxicity in human hepatic cells (2024)
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Metabolism and liver toxicity of cannabidiol (2024)
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Hepatotoxicity of usnic acid and underlying mechanisms (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
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CYP3A Mediates an Unusual C(sp2)−C(sp3) Bond Cleavage via Ipso‐Addition of Oxygen in Drug Metabolism (2024)
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CYP3A Mediates an Unusual C(sp2)−C(sp3) Bond Cleavage via Ipso‐Addition of Oxygen in Drug Metabolism (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells (2023)
Collaboration Network
Top Collaborators
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
- Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway
- Sertraline induces endoplasmic reticulum stress in hepatic cells
Showing 5 of 43 shared publications
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Rat toxicogenomic study reveals analytical consistency across microarray platforms
- Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports
- Review of Usnic Acid and Usnea Barbata Toxicity
Showing 5 of 39 shared publications
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
- Cross-platform comparison of SYBR® Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
Showing 5 of 31 shared publications
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- Rat toxicogenomic study reveals analytical consistency across microarray platforms
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 23 shared publications
- Review of Ginkgo biloba -induced toxicity, from experimental studies to human case reports
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- Endoplasmic reticulum stress and MAPK signaling pathway activation underlie leflunomide-induced toxicity in HepG2 Cells
Showing 5 of 20 shared publications
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 17 shared publications
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The MicroArray Quality Control (MAQC) project shows inter- and intraplatform reproducibility of gene expression measurements
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Next-generation sequencing in the clinic: Promises and challenges
- Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
Showing 5 of 15 shared publications
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 15 shared publications
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 15 shared publications
- Similarities and Differences in the Expression of Drug-Metabolizing Enzymes between Human Hepatic Cell Lines and Primary Human Hepatocytes
- Cross-platform comparison of SYBR® Green real-time PCR with TaqMan PCR, microarrays and other gene expression measurement technologies evaluated in the MicroArray Quality Control (MAQC) study
- Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR γ agonists on rat primary hepatocytes and human HepG2 cells
- Differential gene expression in mouse primary hepatocytes exposed to the peroxisome proliferator-activated receptor α agonists
- Analysis of gene expression changes of drug metabolizing enzymes in the livers of F344 rats following oral treatment with kava extract
Showing 5 of 14 shared publications
- The role of CYP 3A4 and 1A1 in amiodarone-induced hepatocellular toxicity
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Methysticin and 7,8-Dihydromethysticin are Two Major Kavalactones in Kava Extract to Induce CYP1A1
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
Showing 5 of 14 shared publications
- A comprehensive assessment of RNA-seq accuracy, reproducibility and information content by the Sequencing Quality Control Consortium
- A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
- The balance of reproducibility, sensitivity, and specificity of lists of differentially expressed genes in microarray studies
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
Showing 5 of 12 shared publications
- Rat toxicogenomic study reveals analytical consistency across microarray platforms
- Cross-platform comparability of microarray technology: Intra-platform consistency and appropriate data analysis procedures are essential
- Microarray scanner calibration curves: characteristics and implications
- Evaluation of external RNA controls for the assessment of microarray performance
- Differences in hepatotoxicity and gene expression profiles by anti-diabetic PPAR γ agonists on rat primary hepatocytes and human HepG2 cells
Showing 5 of 12 shared publications
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 12 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 12 shared publications
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