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Current · Arkansas
Last published
2026
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OpenAlex · ORCID
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2026-10-06
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Dongying Li
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Also affiliated: Qingdao University (2020); Tulane University (2016–2018); United States Food and Drug Administration (2019–2026); Harvard University (2024); Hainan Normal University (2022–2023); Sun Yat-sen University (2025); Shanghai Jiao Tong University (2022); National Medical Products Administration (2025–2026); Tianjin Medical University Cancer Institute and Hospital (2017–2025); Southern University of Science and Technology (2024–2026); Zhengzhou University (2015–2021); Shanghai Ninth People's Hospital (2022); Second Affiliated Hospital of Nanchang University (2024–2026); China Academy of Chinese Medical Sciences (2013–2024); First Affiliated Hospital of Zhengzhou University (2015–2022); Beijing Fengtai Hospital (2010); Hospital of Stomatology, Sun Yat-sen University (2025); Institute of Chinese Materia Medica (2013); University of Colorado Anschutz (2014–2016); Tianjin Medical University (2017–2025); University of Coimbra (2019); University of Colorado Denver (2014–2016)
20 h-index
102 pubs
1,228 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Dongying Li's research investigates the molecular mechanisms underlying drug and chemical-induced liver toxicity, with a particular focus on the role of microRNAs and long noncoding RNAs in regulating cytochrome P450 expression. This work explores epigenetic mechanisms relevant to environmental toxicology and carcinogenesis.
Li's publications also include studies on cell biology, such as apical lumen formation during epithelial cell polarization and the phosphorylation of FIP5 during mitosis. Additionally, research has examined androgen receptor splice variants in castration resistance and the development of assays for prostate cancer. Collaborations at the National Center for Toxicological Research include work with Baitang Ning, Ting Li, Weida Tong, and Minjun Chen.
With an h-index of 20, 109 total publications, and 1,268 total citations, Li's scholarly contributions span multiple areas of toxicology and molecular biology.
Metrics
- h-index: 20
- Publications: 102
- Citations: 1,228
Selected Publications
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SARS-CoV-2 Spike Protein’s Structural Dynamics Affect the Activity of the Bebtelovimab Antibody (2026)
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Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity (2025)
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Beyond QSARs: Quantitative Knowledge–Activity Relationships (QKARs) for enhanced drug toxicity prediction (2025)
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DILIrank 2.0: An updated and expanded database for drug-induced liver injury risk based on FDA labeling and a literature review (2025)
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New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now? (2025)
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DICTrank Is a Reliable Dataset for Cardiotoxicity Prediction Using Machine Learning Methods (2025)
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A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document (2024)
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DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling (2023)
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DILIrank dataset for QSAR modeling of drug-induced liver injury (2023)
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DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling (2023)
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity (2023)
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Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation (2023)
Collaboration Network
Top Collaborators
Weida Tong
National Center for Toxicological Research
21 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling
- Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
Showing 5 of 21 shared publications
Baitang Ning
National Center for Toxicological Research
21 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
Showing 5 of 21 shared publications
Lei Guo
National Center for Toxicological Research
12 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 12 shared publications
Si Chen
National Center for Toxicological Research
9 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 9 shared publications
Dianke Yu
National Center for Toxicological Research (US)
8 shared publications
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
- FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA
- Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells
Showing 5 of 8 shared publications
Bridgett Knox
National Center for Toxicological Research
8 shared publications
In database
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
- FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA
- Identification of Translational microRNA Biomarker Candidates for Ketoconazole-Induced Liver Injury Using Next-Generation Sequencing
- Microphysiological systems as an emerging in vitro approach for the evaluation of drug absorption, distribution, metabolism, and excretion and toxicity
Showing 5 of 8 shared publications
William H. Tolleson
National Center for Toxicological Research
7 shared publications
In database
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
- Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells
Showing 5 of 7 shared publications
Yanyan Qu
University of Arkansas at Little Rock
6 shared publications
In database
- DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling
- A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document
- DICTrank Is a Reliable Dataset for Cardiotoxicity Prediction Using Machine Learning Methods
- DILIrank 2.0: An updated and expanded database for drug-induced liver injury risk based on FDA labeling and a literature review
- Beyond QSARs: Quantitative Knowledge–Activity Relationships (QKARs) for enhanced drug toxicity prediction
Showing 5 of 6 shared publications
Leihong Wu
National Center for Toxicological Research
4 shared publications
In database
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
- MicroRNAs hsa-miR-495-3p and hsa-miR-486-5p suppress basal and rifampicin-induced expression of human sulfotransferase 2A1 (SULT2A1) by facilitating mRNA degradation
- A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document
- Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells
Zhen Ren
National Center for Toxicological Research (US)
4 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
- Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene
Minjun Chen
National Center for Toxicological Research
4 shared publications
In database
- New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?
- Integrative approaches for studying the role of noncoding RNAs in influencing drug efficacy and toxicity
- DILIrank 2.0: An updated and expanded database for drug-induced liver injury risk based on FDA labeling and a literature review
- DILIrank dataset for QSAR modeling of drug-induced liver injury
Wenming Xiao
National Center for Toxicological Research (US)
3 shared publications
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA-Dependent Gene Regulation of the Human Cytochrome P450
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
Si Chen
Qingdao University (CN)
3 shared publications
- FREMSA: A Method That Provides Direct Evidence of the Interaction between microRNA and mRNA
- Coordinated Regulation of UGT2B15 Expression by Long Noncoding RNA LINC00574 and hsa-miR-129-5p in HepaRG Cells
- Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene
Nan Mei
National Center for Toxicological Research
3 shared publications
In database
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Using a Lentivirus-Based Inducible RNAi Vector to Silence a Gene
Shraddha Thakkar
United States Food and Drug Administration (US)
3 shared publications
- A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document
- Beyond QSARs: Quantitative Knowledge–Activity Relationships (QKARs) for enhanced drug toxicity prediction
- Linking Pharmacogenomic Information on Drug Safety and Efficacy with Ethnic Minority Populations
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