Biography and Research Information
OverviewAI-generated summary
Dongying Li's research focuses on toxicological studies, with a particular emphasis on drug-induced toxicity and the application of genomics in regulatory toxicology. Li has investigated the characterization of cytochrome P450-overexpressing HepG2 cells for assessing liver toxicity and explored the biochemical features and mutations of key proteins in SARS-CoV-2 relevant to RNA therapeutics. A recent publication ranked human drugs by the risk of drug-induced cardiotoxicity using FDA labeling. Li's work also extends to the investigation of traditional Chinese medicine, such as Tanreqing, for its effects on Staphylococcus aureus, and combination therapies like Chenodeoxycholic Acid-Amikacin for bacterial eradication. Li has also contributed to frameworks for integrating large language models into regulatory environments for transparency. With 103 total publications and an h-index of 19, Li collaborates with researchers at the National Center for Toxicological Research, including Ting Li and Weida Tong.
Metrics
- h-index: 19
- Publications: 103
- Citations: 1,189
Selected Publications
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Beyond QSARs: Quantitative Knowledge–Activity Relationships (QKARs) for enhanced drug toxicity prediction (2025)
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New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now? (2025)
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DICTrank Is a Reliable Dataset for Cardiotoxicity Prediction Using Machine Learning Methods (2025)
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A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document (2024)
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DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling (2023)
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DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling (2023)
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Applying genomics in regulatory toxicology: a report of the ECETOC workshop on omics threshold on non-adversity (2023)
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Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation (2023)
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Epigenetics in drug disposition & drug therapy: symposium report of the 24<sup>th</sup> North American meeting of the International Society for the Study of Xenobiotics (ISSX) (2022)
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Integrative approaches for studying the role of noncoding RNAs in influencing drug efficacy and toxicity (2022)
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Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity (2021)
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Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics (2021)
Collaboration Network
Top Collaborators
Yang Zhan
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Guanyi Zhang
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Yanfeng Qi
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Shanshan Bai
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Tianfang Ma
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Oliver Sartor
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Erik K. Flemington
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Peng Lee
18 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 18 shared publications
Xiaojie Wang
14 shared publications
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 5 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 6 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 14 shared publications
Yan Dong
12 shared publications
- Supplementary Table 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 5 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 6 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 12 shared publications
Haitao Zhang
10 shared publications
- Supplementary Figure 4 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 2 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 5 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 6 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 1 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 10 shared publications
Weida Tong
United States Food and Drug Administration (US)
9 shared publications
- Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
- DICTrank: The largest reference list of 1318 human drugs ranked by risk of drug-induced cardiotoxicity using FDA labeling
- A framework enabling LLMs into regulatory environment for transparency and trustworthiness and its application to drug labeling document
- Integrative approaches for studying the role of noncoding RNAs in influencing drug efficacy and toxicity
- New approach methodologies (NAMs) for drug-induced liver injury (DILI): Where are we now?
Showing 5 of 9 shared publications
Yan Dong
6 shared publications
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Figure 3 from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Supplementary Legends from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
- Data from Interplay between Cytoplasmic and Nuclear Androgen Receptor Splice Variants Mediates Castration Resistance
Showing 5 of 6 shared publications
Baitang Ning
National Center for Toxicological Research (US)
5 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Biochemical features and mutations of key proteins in SARS-CoV-2 and their impacts on RNA therapeutics
- Integrative approaches for studying the role of noncoding RNAs in influencing drug efficacy and toxicity
- Epigenetics in drug disposition & drug therapy: symposium report of the 24<sup>th</sup> North American meeting of the International Society for the Study of Xenobiotics (ISSX)
- Pharmacological Effects of Ketoconazole in the Treatment of Steroidogenesis Suppression via CYP17A1 Inhibition May Involve MicroRNA Regulation
Shuhua Ma
Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
5 shared publications
- Traditional Chinese Medicine Tanreqing Targets Both Cell Division and Virulence in Staphylococcus aureus
- Chenodeoxycholic Acid-Amikacin Combination Enhances Eradication of Staphylococcus aureus
- Synergistic Inhibition of MRSA by Chenodeoxycholic Acid and Carbapenem Antibiotics
- Integrative network pharmacology and transcriptomics analysis reveal the mechanism of Tanreqing in the treatment of acne vulgaris
- Assessing Skin Healing and Angiogenesis of Deep Burns in Vivo Using Two-Photon Microscopy in Mice
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