Si Chen Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

39 h-index 191 pubs 4,646 cited

Research Areas

Pharmacological Effects and Toxicity Studies Cancer-related molecular mechanisms research Cardiovascular Function and Risk Factors Mitochondrial Function and Pathology Immune Response and Inflammation Molecular Biology Techniques and Applications Phytochemicals and Antioxidant Activities Ubiquitin and proteasome pathways

Links

ORCID Google Scholar Lab Website Research Group

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OverviewAI-generated summary

Si Chen's research focuses on understanding the molecular mechanisms underlying various biological processes, with a particular emphasis on toxicology, cellular function, and disease pathology. Chen has investigated the protective effects of compounds like lupeol against cardiac hypertrophy, examining the involved signaling pathways such as TLR4-PI3K-Akt-NF-κB. Further work has explored the role of specific proteins, like USP28, in mitigating mitochondrial dysfunction and cardiac issues in diabetic conditions. Chen's publications also delve into the complexities of cancer, including the metabolic interactions between cancer cells and immune cells, the mechanisms of chemotherapy resistance in colorectal cancer stem cells, and the role of long non-coding RNAs (lncRNAs) in non-small cell lung cancer progression.

Metrics

h-index: 39
Publications: 191
Citations: 4,646

Selected Publications

Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025) DOI
Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025) DOI
Metabolism and liver toxicity of cannabidiol (2024) DOI
Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024) DOI
Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells (2023) DOI
The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023) DOI
Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays (2023) DOI
Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells (2022) DOI
Development of benchmark datasets for text mining and sentiment analysis to accelerate regulatory literature review (2022) DOI
Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline (2022) DOI
The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells (2022) DOI
Actein contributes to black cohosh extract‐induced genotoxicity in human TK6 cells (2022) DOI
In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells (2021) DOI
Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice (2021) DOI
Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance (2021) DOI