Si Chen
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Also affiliated: Shenyang Pharmaceutical University (2022); Shanghai University (2024–2025); Guangzhou University of Chinese Medicine (2020); Union Hospital (2025); United States Food and Drug Administration (2013–2025); Southwest University (2022–2024); University of Miami (2015); Xidian University (2018–2019); Harbin Medical University (2014); University of Illinois Urbana-Champaign (2014); Sun Yat-sen University (2019–2025); Jinan University (2006–2011); Duke University (2021); Xuzhou Medical College (2022–2024); Second Military Medical University (2017); German Cancer Research Center (2019); Shenzhen University (2025); Baylor College of Medicine (2021); Capital Medical University (2016–2019); University of Milan (2021); Jilin University (2018–2022); Anhui Medical University (2015); Chinese Academy of Medical Sciences & Peking Union Medical College (2016); Hong Kong University of Science and Technology (2018); Peking University (2017–2018); University of Macau (2016–2021); Nankai University (2012–2015); Heidelberg University (2019); National Medical Products Administration (2022–2024); Sichuan University (2024); Biochemical Society (2025); Liaoning University of Traditional Chinese Medicine (2021); Peking Union Medical College Hospital (2016); Tianjin Medical University General Hospital (2022); Shantou University (2021); University of Florida (2023); Wuhan University (2011–2023); Xinyang Agriculture and Forestry University (2023); Soochow University (2014); Applied Optronics (United States) (2016–2019); Sun Yat-sen Memorial Hospital (2025); Huaian First People’s Hospital (2025); Key Laboratory of Guangdong Province (2020–2021); BeiGene (China) (2019); Nanjing Drum Tower Hospital (2021); Wuhan Business University (2023); First Affiliated Hospital of Shantou University Medical College (2021); Maine Farmland Trust (2021); Beijing Anzhen Hospital (2016); First Hospital of Jilin University (2018–2022); Duke Medical Center (2021); Shanghai East Hospital (2022); University of Kansas Medical Center (2021); The First Affiliated Hospital, Sun Yat-sen University (2023); Anhui Provincial Hospital (2015); Miami Heart Research Institute (2015); Chinese Academy of Agricultural Sciences (2019–2024); Renmin Hospital of Wuhan University (2021–2023); China XD Group (China) (2018); Sun Yat-sen University Cancer Center (2022); Beijing Friendship Hospital (2019); Tianjin Municipal Research Institute for Family Planning (2014); Food and Drug Administration (2024–2025); Erasmus MC Cancer Institute (2017); Ministry of Agriculture and Rural Affairs (2021–2022); Duke University Hospital (2021); Ningbo University Affiliated Hospital (2017); Tumor Hospital of Guangxi Medical University (2020); Ministry of Education (2016); Children's Hospital of Chongqing Medical University (2024); Henan Institute of Science and Technology (2024–2025); Union Hospital (2024); Huazhong University of Science and Technology (2024–2025); China Agricultural University (2012); City University of Macau (2021); East China Normal University (2020); Harbin Veterinary Research Institute (2019); Nanjing Medical University (2013–2025); Chongqing Medical University (2024); University of Hong Kong (2018); Northwest A&F University (2017); China Medical University (2022); Florida College (2023)
Upstream record may be merged OpenAlex, the source of these figures, lists 85 institutions in 10 countries for this author record — a pattern that usually means it combines several researchers with similar names. The totals above may include work by other people.
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Si Chen's research program investigates molecular mechanisms underlying disease progression and therapeutic resistance, with a focus on cancer and metabolic disorders. Their work has explored the role of specific proteins and signaling pathways in promoting tumor metastasis, stemness, and resistance to chemotherapy, as seen in studies on SOX2, TFAP2C, and the WNT/β-catenin and hippo signaling pathways. Additionally, Chen's research has examined the impact of metabolic dysregulation on organ function, including the role of trimethylamine N-oxide in aggravating liver steatosis and the protective function of USP28 in the diabetic heart. Their publications also touch upon the development of novel biomaterials, such as hydrogels derived from chitin, and their biocompatibility.
With a substantial publication record of 191 articles and an h-index of 40, Si Chen is recognized as a highly cited researcher. Their laboratory maintains an active research group and collaborates extensively with colleagues at the National Center for Toxicological Research, including Lei Guo, Xilin Li, Yuxi Li, and Nan Mei, with whom they have co-authored numerous publications. This collaborative network facilitates ongoing investigations into complex biological processes and disease pathogenesis.
Metrics
- h-index: 40
- Publications: 191
- Citations: 4,885
Selected Publications
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Corrigendum to “Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver” [J. Pharm. Biomed. Anal. 265 (2025) 117034] (2026)
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Translating in vitro mechanistic findings to in vivo toxicity outcomes: A case study of Usnic acid hepatotoxicity (2026)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin in vivo (2025)
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Characterizing the metabolites of the tyrosine-kinase inhibitor pexidartinib in mouse feces, urine, plasma, and liver (2025)
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Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025)
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025)
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Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025)
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Metabolism and liver toxicity of cannabidiol (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
Collaboration Network
Top Collaborators
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
- Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway
- Sertraline induces endoplasmic reticulum stress in hepatic cells
Showing 5 of 43 shared publications
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 17 shared publications
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
- Sertraline, an Antidepressant, Induces Apoptosis in Hepatic Cells Through the Mitogen-Activated Protein Kinase Pathway
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Mechanism study of goldenseal-associated DNA damage
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 17 shared publications
- Development of HepG2-derived cells expressing cytochrome P450s for assessing metabolism-associated drug-induced liver toxicity
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 12 shared publications
- Micrornas as Pharmacogenomic Biomarkers for Drug Efficacy and Drug Safety Assessment
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
Showing 5 of 12 shared publications
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
Showing 5 of 12 shared publications
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
Showing 5 of 12 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
Showing 5 of 11 shared publications
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- A systematic evaluation of microRNAs in regulating human hepatic CYP2E1
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 10 shared publications
- Regulation of cytochrome P450 expression by microRNAs and long noncoding RNAs: Epigenetic mechanisms in environmental toxicology and carcinogenesis
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 9 shared publications
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
- Long noncoding RNA LINC00844-mediated molecular network regulates expression of drug metabolizing enzymes and nuclear receptors in human liver cells
Showing 5 of 7 shared publications
- Ginkgo biloba leaf extract induces DNA damage by inhibiting topoisomerase II activity in human hepatic cells
- Revisiting the mutagenicity and genotoxicity of N-nitroso propranolol in bacterial and human in vitro assays
- Mitochondrial dysfunction and apoptosis underlie the hepatotoxicity of perhexiline
- Evaluation of pyrrolizidine alkaloid-induced genotoxicity using metabolically competent TK6 cell lines
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 7 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The role of hepatic cytochrome P450s in the cytotoxicity of sertraline
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
Showing 5 of 7 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells
Showing 5 of 6 shared publications
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA hsa-miR-370-3p suppresses the expression and induction of CYP2D6 by facilitating mRNA degradation
- The expression, induction and pharmacological activity of CYP1A2 are post-transcriptionally regulated by microRNA hsa-miR-132-5p
- MicroRNA hsa-miR-25-3p suppresses the expression and drug induction of CYP2B6 in human hepatocytes
- A systematic evaluation of microRNAs in regulating human hepatic CYP2E1
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