Jason Farrar

High Impact

Professor

University of Arkansas for Medical Sciences

faculty

Peds Pediatrics, College of Medicine

24 h-index 145 pubs 2,978 cited

Research Areas

Acute Myeloid Leukemia Research Cancer Genomics and Diagnostics Child and Adolescent Health Cancer-related molecular mechanisms research Genomics and Chromatin Dynamics Molecular Biology Techniques and Applications Health Sciences Research and Education Childhood Cancer Survivors' Quality of Life

Links

ORCID Lab Website UAMS TRI Profile

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OverviewAI-generated summary

Jason Farrar's research program focuses on the molecular and clinical characterization of pediatric acute myeloid leukemia (AML) and related hematologic malignancies. He investigates genetic alterations, stem cell signatures, and long noncoding RNA expression as predictors of outcome in these diseases. His work also extends to understanding the mechanisms of leukemogenesis, such as the role of specific gene fusions and their impact on cellular processes.

Farrar is involved in the diagnosis, treatment, and surveillance of rare genetic syndromes, including Diamond-Blackfan anemia. He also explores the implementation of pharmacogenomics testing in clinical settings, as demonstrated by his experience at Arkansas Children’s Hospital. His research has been supported by federal grants, including a $756,000 award from the NIH/National Center for Advancing Translational Sciences for the CTSA K12 Program at the University of Arkansas for Medical Sciences, where he serves as Co-PI.

With a substantial publication record, including 145 total publications and an h-index of 24, Farrar has contributed significantly to the field. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Samrat Roy Choudhury and Dr. Stephanie Byrum, with whom he has co-authored multiple publications. His scholarship has been recognized, designating him as a high-impact researcher.

Metrics

h-index: 24
Publications: 145
Citations: 2,978

Selected Publications

Central nervous system-symptomatic hyperammonemia following recombinant crisantaspase Pseudomonas fluorescens (2026) DOI
A supervised STreNgth & Outpatient Exercise Regimen in pediatric patients with Acute Lymphoblastic Leukemia (STRONGER ALL) (2026) DOI
Eltrombopag in combination with immunosuppressive therapy in pediatric severe aplastic anemia: phase 2 ESCALATE trial (2025) DOI
Lymphoid malignancies in patients with Shwachman-Diamond syndrome (2025) DOI
Evaluation of recurrent and recalcitrant warts in a deaf adolescent male reveals GATA2 deficiency (2024) DOI
Diagnosis, treatment, and surveillance of Diamond-Blackfan anaemia syndrome: international consensus statement (2024) DOI
Abstract P16: CBFA2T3-GLIS2 fusion leads to a distinct DNA methylation enhancer landscape in pediatric acute myeloid leukemia (2024) DOI
Enhancer‐activated <scp>RET</scp> confers protection against oxidative stress to <scp>KMT2A</scp>‐rearranged acute myeloid leukemia (2024) DOI
Lymphoid Malignancies in Shwachman-Diamond Syndrome: Incidence, Clinical Features, and Outcomes from the North American SDS Registry (2023) DOI
The Role of FAS Receptor Methylation in Osteosarcoma Metastasis (2023) DOI
Long Noncoding RNA Expression Independently Predicts Outcome in Pediatric Acute Myeloid Leukemia (2023) DOI
Transcriptome Analysis and Machine Learning Prioritize Therapeutic Strategies for High-Risk Pediatric AML Patients of the KMT2A-Fusion Subgroup (2022) DOI
Expanding the High-Risk Definition for Children with Newly Diagnosed Acute Myeloid Leukemia (2022) DOI
Eltrombopag in Pediatric Patients with Previously Untreated or Refractory/Relapsed Severe Aplastic Anemia: The Phase II Escalate Trial (2022) DOI
Integrated stem cell signature and cytomolecular risk determination in pediatric acute myeloid leukemia (2022) DOI

Federal Grants 1 $756,000 total

NIH/National Center for Advancing Translational Sciences Co-PI Jul 2024 - Jun 2029

CTSA K12 Program at the University of Arkansas for Medical Sciences

National Center for Advancing Translational Sciences $756,000 K12

Grants & Funding

No FP attached UAMS ACHRI Flow Through Principal Investigator
GR034151 Farrar ACHRI Mechanisms of Erythroid Remission in Diamond Blackfan Anemia (DBA) UAMS ACHRI Flow Through Principal Investigator
No FP attached UAMS ACHRI Flow Through Principal Investigator
Integrative Genomics in Pediatric AML Arkansas Children's Research Institute Principal Investigator
No FP attached UAMS ACHRI Flow Through Principal Investigator
Role of HELB in the Replication Stress Response Dr. Tacketts COBRA through ACRI NIH/Nat. Inst. of General Medical Sciences - Pass Through: Arkansas Children's Research Institute Principal Investigator
St. Baldrick's Subaward St. Baldrick's Foundation - Pass Through: Fred Hutchinson Cancer Research Center Principal Investigator
No FP attached UAMS ACHRI Flow Through Principal Investigator