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Current · Arkansas
Last published
2025
Sources
OpenAlex · ORCID
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2026-10-06
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Svitlana Shpyleva
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Also affiliated: Arkansas Children's Hospital (2013–2017); United States Food and Drug Administration (2010–2025); R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (2009–2012); Arkansas Children's Research Institute (2013–2017)
16 h-index
31 pubs
1,449 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Svitlana Shpyleva's research focuses on the molecular mechanisms underlying disease, particularly cancer and neurological disorders. Her work has investigated alterations in microRNAs and their association with acquired resistance in breast cancer cells to chemotherapeutic agents like cisplatin. She has also explored the role of ferritin in human breast cancer cells and iron metabolism disturbances in breast cancer cells resistant to doxorubicin and cisplatin. Shpyleva's research extends to epigenetic regulation, including the study of DNA methylation and microRNA-mediated dysregulation in liver carcinogenesis. She has also examined oxidative DNA damage and altered DNA methylation in mouse models of autism, with implications for human post-mortem cerebellum studies. Her research group includes collaborators such as Leihong Wu and Joshua Xu from the National Center for Toxicological Research. Shpyleva has an h-index of 16, with 31 publications and 1,450 citations.
Metrics
- h-index: 16
- Publications: 31
- Citations: 1,449
Selected Publications
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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Assessing the performance of large language models in literature screening for pharmacovigilance: a comparative study (2024)
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Development of benchmark datasets for text mining and sentiment analysis to accelerate regulatory literature review (2022)
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Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro (2017)
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Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice (2017)
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Overexpression of LINE-1 Retrotransposons in Autism Brain (2017)
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Organ-specific epigenetic changes induced by the non-genotoxic liver carcinogen methapyrilene in Fischer 344 rats (2016)
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Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein (2016)
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Sex-specific effects of cytotoxic chemotherapy agents cyclophospha-mide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus – an aging connection (2016)
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Abstract 920: Mechanism of the transferrin receptor 1 dysregulation in hepatocarcinogenesis (2015)
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MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis (2015)
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Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice (2015)
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Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum (2014)
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Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism (2014)
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Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum (2014)
Collaboration Network
Top Collaborators
Igor P. Pogribny
National Center for Toxicological Research
22 shared publications
In database
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Role of ferritin alterations in human breast cancer cells
- Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Overexpression of LINE-1 Retrotransposons in Autism Brain
Showing 5 of 22 shared publications
Frederick A. Beland
National Center for Toxicological Research
16 shared publications
In database
- Role of ferritin alterations in human breast cancer cells
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin
- Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
Showing 5 of 16 shared publications
Volodymyr Tryndyak
National Center for Toxicological Research
14 shared publications
In database
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Role of ferritin alterations in human breast cancer cells
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin
Showing 5 of 14 shared publications
Stepan Melnyk
University of Arkansas for Medical Sciences
7 shared publications
In database
- Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
- Overexpression of LINE-1 Retrotransposons in Autism Brain
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum
- Sex-specific effects of cytotoxic chemotherapy agents cyclophospha-mide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus – an aging connection
Showing 5 of 7 shared publications
Aline de Conti
National Center for Toxicological Research (US)
6 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein
- Organ-specific epigenetic changes induced by the non-genotoxic liver carcinogen methapyrilene in Fischer 344 rats
- Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro
Showing 5 of 6 shared publications
S. Jill James
Arkansas Children's Hospital
5 shared publications
In database
- Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
- Overexpression of LINE-1 Retrotransposons in Autism Brain
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum
- Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet
Olga Kovalchuk
University of Lethbridge (CA)
5 shared publications
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Role of ferritin alterations in human breast cancer cells
- Sex-specific effects of cytotoxic chemotherapy agents cyclophospha-mide and mitomycin C on gene expression, oxidative DNA damage, and epigenetic alterations in the prefrontal cortex and hippocampus – an aging connection
- Chemo brain or tumor brain - that is the question: the presence of extracranial tumors profoundly affects molecular processes in the prefrontal cortex of TumorGraft mice
- Abstract 2313: Role of ferritin dysregulation in human breast cancer cells
Levan Muskhelishvili
National Center for Toxicological Research (US)
4 shared publications
- Role of DNA damage and alterations in cytosine DNA methylation in rat liver carcinogenesis induced by a methyl-deficient diet
- Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism
- Chronic Administration of 2-Acetylaminofluorene Alters the Cellular Iron Metabolism in Rat Liver
- Abstract 5556: Role of the aberrant intracellular iron metabolism in rat liver carcinogenesis
Iryna Kindrat
National Center for Toxicological Research (US)
4 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Organ-specific epigenetic changes induced by the non-genotoxic liver carcinogen methapyrilene in Fischer 344 rats
- Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro
- Abstract 920: Mechanism of the transferrin receptor 1 dysregulation in hepatocarcinogenesis
В Ф Чехун
R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (UA)
3 shared publications
- Role of ferritin alterations in human breast cancer cells
- Iron metabolism disturbances in the MCF-7 human breast cancer cells with acquired resistance to doxorubicin and cisplatin
- Abstract 2313: Role of ferritin dysregulation in human breast cancer cells
Marta Pogribna
National Center for Toxicological Research
3 shared publications
In database
- Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
- Interstrain differences in the progression of nonalcoholic steatohepatitis to fibrosis in mice are associated with altered hepatic iron metabolism
- Suppressing activity of tributyrin on hepatocarcinogenesis is associated with inhibiting the p53-CRM1 interaction and changing the cellular compartmentalization of p53 protein
Oleksandra Pavliv
Arkansas Children's Hospital
3 shared publications
In database
- Complex epigenetic regulation of Engrailed-2 (EN-2) homeobox gene in the autism cerebellum
- Overexpression of LINE-1 Retrotransposons in Autism Brain
- Elevated 5-hydroxymethylcytosine in the Engrailed-2 (EN-2) promoter is associated with increased gene expression and decreased MeCP2 binding in autism cerebellum
H. M. Еrstenyuk
Ivano-Frankivsk National Medical University (UA)
3 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro
- Abstract 920: Mechanism of the transferrin receptor 1 dysregulation in hepatocarcinogenesis
Masato Tsuchiya
University of North Carolina at Chapel Hill (US)
2 shared publications
- Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma
- Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice
Ivan Rusyn
University of North Carolina at Chapel Hill (US)
2 shared publications
- Comparative analysis of promoter methylation and gene expression endpoints between tumorous and non-tumorous tissues from HCV-positive patients with hepatocellular carcinoma
- Differentially expressed MicroRNAs provide mechanistic insight into fibrosis-associated liver carcinogenesis in mice
Similar Researchers
Based on overlapping research topics
Volodymyr Tryndyak
National Center for Toxicological Research
Cancer-related molecular mechanisms research
Epigenetics and DNA Methylation
MicroRNA in disease regulation
Igor P. Pogribny
National Center for Toxicological Research
Cancer-related molecular mechanisms research
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MicroRNA in disease regulation
Pieter Jan Koopmans
University of Arkansas at Fayetteville
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George Hammons
National Center for Toxicological Research
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Whitney Ann Lowe
University of Arkansas at Fayetteville
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Gracien Jules
University of Arkansas at Fayetteville
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