Nysia I. George
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Also affiliated: United States Food and Drug Administration (2009–2026); University of Michigan (2010); Texas A&M University (2008)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Nysia I. George's research has focused on investigating the physiological effects of various substances and conditions in animal models and humans, with an emphasis on toxicity and disease mechanisms. Her work includes studies on the cardiovascular toxicity of compounds like doxorubicin and Citrus aurantium in rodent models, as well as examining sex differences in cardiovascular disease risk. George has also explored the impact of ketamine treatment on developing rat brains using electron microscopy to study mitochondrial defects. Her research extends to human health, with a systematic review and meta-analysis on cardiovascular disease risk factors and an epigenome-wide association study identifying DNA methylation signatures in systemic lupus erythematosus. She has published 41 papers, accumulating 925 citations, and holds an h-index of 19. George has collaborated with researchers from the National Center for Toxicological Research and the University of Arkansas for Medical Sciences.
Metrics
- h-index: 18
- Publications: 39
- Citations: 901
Selected Publications
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Correction: Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study (2026)
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Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study (2025)
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Low-Frequency Mutational Heterogeneity of Invasive Ductal Carcinoma Subtypes: Information to Direct Precision Oncology (2019)
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Electron microscopy techniques employed to explore mitochondrial defects in the developing rat brain following ketamine treatment (2018)
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Epigenome-wide association study of peripheral blood mononuclear cells in systemic lupus erythematosus: Identifying DNA methylation signatures associated with interferon-related genes based on ethnicity and SLEDAI (2018)
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Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine (2017)
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Multi-class computational evolution: development, benchmark evaluation and application to RNA-Seq biomarker discovery (2017)
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Evaluation of the risk of perchlorate exposure in a population of late-gestation pregnant women in the United States: Application of probabilistic biologically-based dose response modeling (2017)
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Assessing Sex Differences in the Risk of Cardiovascular Disease and Mortality per Increment in Systolic Blood Pressure: A Systematic Review and Meta-Analysis of Follow-Up Studies in the United States (2017)
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Estimation of iodine nutrition and thyroid function status in late-gestation pregnant women in the United States: Development and application of a population-based pregnancy model (2016)
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Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice (2016)
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Dietary Iodine Sufficiency and Moderate Insufficiency in the Lactating Mother and Nursing Infant: A Computational Perspective (2016)
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Cost-sensitive performance metric for comparing multiple ordinal classifiers (2016)
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Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood (2015)
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An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data (2015)
Collaboration Network
Top Collaborators
- An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague–Dawley rats during the waking (lights off) cycle
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
Showing 5 of 11 shared publications
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague–Dawley rats during the waking (lights off) cycle
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
- Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
- Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood
Showing 5 of 6 shared publications
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
- Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Endoplasmic reticulum stress responses differ in meninges and associated vasculature, striatum, and parietal cortex after a neurotoxic amphetamine exposure
- Amphetamine and environmentally induced hyperthermia differentially alter the expression of genes regulating vascular tone and angiogenesis in the meninges and associated vasculature
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Assessing Sex Differences in the Risk of Cardiovascular Disease and Mortality per Increment in Systolic Blood Pressure: A Systematic Review and Meta-Analysis of Follow-Up Studies in the United States
- An Iterative Leave-One-Out Approach to Outlier Detection in RNA-Seq Data
- DAFS: a data-adaptive flag method for RNA-sequencing data to differentiate genes with low and high expression
- Cost-sensitive performance metric for comparing multiple ordinal classifiers
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice
- Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study
- Correction: Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice
- Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study
- Correction: Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study
- Comparison of the global gene expression of choroid plexus and meninges and associated vasculature under control conditions and after pronounced hyperthermia or amphetamine toxicity
- Model Uncertainty and Model Averaging in the Estimation of Infectious Doses for Microbial Pathogens
- Batch Effect Estimation of Microarray Platforms with Analysis of Variance
- Quantitative global sensitivity analysis of a biologically based dose-response pregnancy model for the thyroid endocrine system
- Evaluation of the risk of perchlorate exposure in a population of late-gestation pregnant women in the United States: Application of probabilistic biologically-based dose response modeling
- Estimation of iodine nutrition and thyroid function status in late-gestation pregnant women in the United States: Development and application of a population-based pregnancy model
- A comparison of methylphenidate-, amphetamine-, and methamphetamine-induced hyperthermia and neurotoxicity in male Sprague–Dawley rats during the waking (lights off) cycle
- A Visual Description of the Dissection of the Cerebral Surface Vasculature and Associated Meninges and the Choroid Plexus from Rat Brain
- Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity
- Corticosterone and exogenous glucose alter blood glucose levels, neurotoxicity, and vascular toxicity produced by methamphetamine
- Evaluating the Stability of RNA-Seq Transcriptome Profiles and Drug-Induced Immune-Related Expression Changes in Whole Blood
- Serum myoglobin, but not lipopolysaccharides, is predictive of AMPH-induced striatal neurotoxicity
- Physiological effects following administration of Citrus aurantium for 28 days in rats
- Cardiovascular Toxicity of Citrus aurantium in Exercised Rats
- Response to Letter to the Editor
- Physiological effects following administration of Citrus aurantium for 28 days in rats
- Cardiovascular Toxicity of Citrus aurantium in Exercised Rats
- Response to Letter to the Editor
- Physiological effects following administration of Citrus aurantium for 28 days in rats
- Cardiovascular Toxicity of Citrus aurantium in Exercised Rats
- Response to Letter to the Editor
- Physiological effects following administration of Citrus aurantium for 28 days in rats
- Cardiovascular Toxicity of Citrus aurantium in Exercised Rats
- Response to Letter to the Editor
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