James J. Greenhaw

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NCTR primary UAMS

Also affiliated: United States Food and Drug Administration (2011–2024); Center for Drug Evaluation and Research (2020); University of Miami (2003); University of Tennessee Health Science Center (2001–2003); PAREXEL International (United States) (2012); University of Memphis (1990)

19 h-index 37 pubs 886 cited

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James Greenhaw's research focuses on the pharmacokinetic analysis of substances in animal models, particularly Sprague-Dawley rats. His recent work, published in 2024, investigated the pharmacokinetics of nicotine and its metabolites under various administration routes, including nose-only inhalation, oral gavage, and intravenous infusion in male rats. Greenhaw has published 37 papers with a total of 871 citations, reflecting a scholarly h-index of 19. He collaborates with several colleagues at the National Center for Toxicological Research, including Matthew Bryant, Xiaobo He, Seonggi Min, and Florence McLellen, with whom he shares one publication each.

Metrics

h-index: 19
Publications: 37
Citations: 886

Selected Publications

Pharmacokinetic analysis of nicotine and its metabolites (cotinine and trans-3′-hydroxycotinine) in male Sprague-Dawley rats following nose-only inhalation, oral gavage, and intravenous infusion of nicotine (2024)

Toxicological Sciences 9 citations DOI OpenAlex
Hepatic Transcript Profiles of Cytochrome P450 Genes Predict Sex Differences in Drug Metabolism (2020)

Drug Metabolism and Disposition 22 citations DOI OpenAlex
A randomized controlled laboratory study on the long-term effects of methylphenidate on cardiovascular function and structure in rhesus monkeys (2018)

Pediatric Research 9 citations DOI OpenAlex
Cytotoxicity of 34 FDA approved small-molecule kinase inhibitors in primary rat and human hepatocytes (2018)

Toxicology Letters 36 citations DOI OpenAlex
Drug-Induced Liver Injury in Children: Clinical Observations, Animal Models, and Regulatory Status (2017)

International Journal of Toxicology 44 citations DOI OpenAlex
Effects of 31 FDA approved small-molecule kinase inhibitors on isolated rat liver mitochondria (2016)

Archives of Toxicology 97 citations DOI OpenAlex
Potential of extracellular microRNAs as biomarkers of acetaminophen toxicity in children (2015)

Toxicology and Applied Pharmacology 78 citations DOI OpenAlex
Regorafenib impairs mitochondrial functions, activates AMP-activated protein kinase, induces autophagy, and causes rat hepatocyte necrosis (2014)

Toxicology 56 citations DOI OpenAlex
Identification of a metabolic biomarker panel in rats for prediction of acute and idiosyncratic hepatotoxicity (2014)

Computational and Structural Biotechnology Journal 19 citations DOI OpenAlex
Detection of hepatotoxicity potential with metabolite profiling (metabolomics) of rat plasma (2014)

Toxicology Letters 73 citations DOI OpenAlex
Comprehensive analysis of alterations in lipid and bile acid metabolism by carbon tetrachloride using integrated transcriptomics and metabolomics (2014)

Metabolomics 6 citations DOI OpenAlex
Study Protocol Preparation, Review, and Approval (2013)

Elsevier eBooks DOI OpenAlex
Good Laboratory Practices (2013)

Elsevier eBooks 1 citation DOI OpenAlex
Introduction (2013)

Elsevier eBooks 1 citation DOI OpenAlex
Final Report, Study Close-Out, and Conclusions (2013)

Elsevier eBooks DOI OpenAlex