Match tier
Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
V
Varsha G. Desai
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Biologist
Also affiliated: United States Department of Health and Human Services (1997); United States Food and Drug Administration (1996–2026); King Edward Memorial Hospital and Seth G.S. Medical College (1991); University of Michigan (2007); MIT World Peace University (2025–2026)
24 h-index
68 pubs
1,891 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Varsha G. Desai's research focuses on understanding the mechanisms of drug-induced toxicity, particularly cardiotoxicity associated with the chemotherapy agent doxorubicin. Her work investigates how this drug affects the heart, with a recent emphasis on identifying early preclinical biomarkers for chronic cardiotoxicity. Desai has published studies exploring the role of microRNAs, such as microRNA-34a-5p, as potential circulating biomarkers for detecting this condition before clinical symptoms manifest.
Her research also examines sex-related differences in doxorubicin-induced cardiotoxicity, investigating pathways like the apelin-APJ system. Desai has explored strategies to mitigate this toxicity, including targeting the apelin-APJ axis. Her work has involved studies in animal models, including mice and rats, to elucidate disease mechanisms and evaluate potential therapeutic interventions. Collaborations include researchers from the National Center for Toxicological Research and the University of Arkansas for Medical Sciences.
Metrics
- h-index: 24
- Publications: 68
- Citations: 1,891
Positions
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Research Biologist 1993–presentNational Center for Toxicological Research Division of Systems Biology ORCID
Selected Publications
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Correction: Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study (2026)
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Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study (2025)
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Doxorubicin Cardiotoxicity: Preclinical and Clinical Circulating Protein Markers (2023)
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Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice (2022)
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Doxorubicin Cardiotoxicity: Preclinical and Clinical Circulating Protein Markers (2022)
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MicroRNA‐34a‐5p as a promising early circulating preclinical biomarker of doxorubicin‐induced chronic cardiotoxicity (2022)
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Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice (2021)
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Rebuttal to the comments by Dr. Yan Xu on the article “Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone” (2019)
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Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice (2018)
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Transcript profiling in the testes and prostates of postnatal day 30 Sprague-Dawley rats exposed prenatally and lactationally to 2-hydroxy-4-methoxybenzophenone (2018)
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In Vitro Modulation of Redox and Metabolism Interplay at the Brain Vascular Endothelium: Genomic and Proteomic Profiles of Sulforaphane Activity (2018)
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MitoChip (2018)
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Sex and age differences in the expression of liver microRNAs during the life span of F344 rats (2017)
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Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice (2016)
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Early metabolomics changes in heart and plasma during chronic doxorubicin treatment in B6C3F1 mice (2016)
Collaboration Network
Top Collaborators
James C. Fuscoe
National Center for Toxicological Research
34 shared publications
In database
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Analysis of variance components in gene expression data
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
- Age and sex differences in kidney microRNA expression during the life span of F344 rats
Showing 5 of 34 shared publications
Carrie L. Moland
National Center for Toxicological Research
29 shared publications
In database
- Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
Showing 5 of 29 shared publications
Vikrant Vijay
National Center for Toxicological Research
20 shared publications
In database
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Age and sex differences in kidney microRNA expression during the life span of F344 rats
- Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages
- Sex differences in kidney gene expression during the life cycle of F344 rats
- Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice
Showing 5 of 20 shared publications
Taewon Lee
Department of Mathematical Sciences (RU)
20 shared publications
- Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
Showing 5 of 20 shared publications
William S. Branham
National Center for Toxicological Research (US)
15 shared publications
- Transgenic expression of proximal tubule peroxisome proliferator–activated receptor-α in mice confers protection during acute kidney injury
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Underlying mitochondrial dysfunction triggers flutamide-induced oxidative liver injury in a mouse model of idiosyncratic drug toxicity
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
- Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements.
Showing 5 of 15 shared publications
Ritchie J. Feuers
National Center for Toxicological Research (US)
10 shared publications
- Influences of Age and Dietary Restriction on Gastrocnemius Electron Transport System Activities in Mice
- MPP+-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport
- Hypothermia enhances bcl-2 expression and protects against oxidative stress-induced cell death in chinese hamster ovary cells
- Impaired Glutathione Peroxidase Activity Accounts for the Age-Related Accumulation of Hydrogen Peroxide in Activated Human Neutrophils
- Activity Profile of Glutathione-Dependent Enzymes and Respiratory Chain Complexes in Rats Supplemented with Antioxidants and Treated with Carcinogens
Showing 5 of 10 shared publications
Tao Han
National Center for Toxicological Research (US)
9 shared publications
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Elimination of laboratory ozone leads to a dramatic improvement in the reproducibility of microarray gene expression measurements.
- Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice
- Sex and age differences in the expression of liver microRNAs during the life span of F344 rats
- Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Showing 5 of 9 shared publications
Sherry M. Lewis
National Center for Toxicological Research
9 shared publications
In database
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Effect of (+)-usnic acid on mitochondrial functions as measured by mitochondria-specific oligonucleotide microarray in liver of B6C3F1 mice
- Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice
- Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice
Showing 5 of 9 shared publications
Joshua C. Kwekel
National Center for Toxicological Research (US)
7 shared publications
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Age and sex dependent changes in liver gene expression during the life cycle of the rat
- Age and sex differences in kidney microRNA expression during the life span of F344 rats
- Sexual Dimorphism in the Expression of Mitochondria-Related Genes in Rat Heart at Different Ages
- Sex differences in kidney gene expression during the life cycle of F344 rats
Showing 5 of 7 shared publications
Robert R. Delongchamp
National Center for Toxicological Research
7 shared publications
In database
- Analysis of variance components in gene expression data
- Changes in expression level of genes as a function of time of day in the liver of rats
- Nucleoside reverse transcriptase inhibitors (NRTIs)-induced expression profile of mitochondria-related genes in the mouse liver
- Development of mitochondria-specific mouse oligonucleotide microarray and validation of data by real-time PCR
- Testing for treatment effects on gene ontology
Showing 5 of 7 shared publications
Anane Aidoo
National Center for Toxicological Research (US)
6 shared publications
- Attenuation of bleomycin-induced Hprt mutant frequency in female and male rats by calorie restriction
- Expression Analysis of Hepatic Mitochondria-Related Genes in Mice Exposed to Acrylamide and Glycidamide
- Activity Profile of Glutathione-Dependent Enzymes and Respiratory Chain Complexes in Rats Supplemented with Antioxidants and Treated with Carcinogens
- Influence of dietary antioxidants on the mutagenicity of 7,12-dimethylbenz[a]anthracene and bleomycin in female rats
- Effects of Bleomycin on Liver Antioxidant Enzymes and the Electron Transport System From Ad Libitum-Fed and Dietary-Restricted Female and Male Fischer 344 Rats
Showing 5 of 6 shared publications
Eugene H. Herman
National Cancer Institute (UA)
6 shared publications
- Development of doxorubicin-induced chronic cardiotoxicity in the B6C3F1 mouse model
- Early biomarkers of doxorubicin-induced heart injury in a mouse model
- Sex-related differential susceptibility to doxorubicin-induced cardiotoxicity in B6C3F1 mice
- Early transcriptional changes in cardiac mitochondria during chronic doxorubicin exposure and mitigation by dexrazoxane in mice
- Candidate early predictive plasma protein markers of doxorubicin-induced chronic cardiotoxicity in B6C3F1 mice
Showing 5 of 6 shared publications
Daniel A. Casciano
National Center for Toxicological Research (US)
5 shared publications
- Attenuation of bleomycin-induced Hprt mutant frequency in female and male rats by calorie restriction
- Activity Profile of Glutathione-Dependent Enzymes and Respiratory Chain Complexes in Rats Supplemented with Antioxidants and Treated with Carcinogens
- Effects of Bleomycin on Liver Antioxidant Enzymes and the Electron Transport System From Ad Libitum-Fed and Dietary-Restricted Female and Male Fischer 344 Rats
- Modulation of antioxidant enzymes in bleomycin‐treated rats by vitamin c and β‐carotene
- Effect of p53 genotype on gene expression profiles in murine liver
Bounleut Phanavanh
National Center for Toxicological Research
5 shared publications
In database
- Doxorubicin‐induced delayed‐onset subclinical cardiotoxicity in mice
- MicroRNA‐34a‐5p as a promising early circulating preclinical biomarker of doxorubicin‐induced chronic cardiotoxicity
- Potential role of the apelin‐APJ pathway in sex‐related differential cardiotoxicity induced by doxorubicin in mice
- Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study
- Correction: Exploring Predictive Risk Factors for Myocardial Injury in Children Treated with Anthracyclines: A Pilot Study
Ronald W. Hart
National Center for Toxicological Research (US)
4 shared publications
- Influences of Age and Dietary Restriction on Gastrocnemius Electron Transport System Activities in Mice
- MPP+-induced neurotoxicity in mouse is age-dependent: evidenced by the selective inhibition of complexes of electron transport
- Impaired Glutathione Peroxidase Activity Accounts for the Age-Related Accumulation of Hydrogen Peroxide in Activated Human Neutrophils
- A circadian study of liver antioxidant enzyme systems of female Fischer-344 rats subjected to dietary restriction for six weeks.
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