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Presence Current · Arkansas
Last published 2024
Sources OpenAlex · ORCID
Refreshed 2026-10-08

Sorena Lo

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6 h-index 8 pubs 77 cited

  • Kidney Transplantation
  • Animals
  • Kidney
  • Male
  • Proteasome Endopeptidase Complex
  • Rats
  • Mitochondria
  • Humans
  • Cryopreservation
  • Proteostasis
  • Cell Line
  • Cold Temperature
  • Organ Preservation
  • Rats, Inbred Lew
  • Interferon-gamma

Biography and Research Information

OverviewAI-generated summary

Sorena Lo's research investigates the impact of cold storage and transplantation on kidney function, with a particular focus on proteasome function and mitochondrial protein homeostasis. Lo has published work examining how renal cold storage prior to transplantation impairs proteasome function and mitochondrial proteostasis, potentially leading to exacerbated renal damage. Further research has explored methods to mitigate these effects, including targeting mitochondria during cold storage and investigating the role of specific molecules like the BK activator NS11021 in protecting kidneys from cold storage-induced injury. Lo's work also addresses the immune response, noting the aberrant activation of the complement system and the induction of interferon-gamma and STAT-1 in kidney grafts following cold storage and transplantation. Collaborations include Nirmala Parajuli, Dinesh Bhattarai, Neriman Gökden, and Seongok Lee, all at the University of Arkansas for Medical Sciences, with whom Lo has co-authored multiple publications.

Metrics

  • h-index: 6
  • Publications: 8
  • Citations: 77

Selected Publications

  • Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function (2024)
    Kidney360 4 citations DOI OpenAlex
  • Cold Storage Followed by Transplantation Induces Interferon-Gamma and STAT-1 in Kidney Grafts (2023)
    International Journal of Molecular Sciences 6 citations DOI OpenAlex
  • Aberrant activation of the complement system in renal grafts is mediated by cold storage (2021)
    American Journal of Physiology-Renal Physiology 13 citations DOI OpenAlex
  • The BK activator NS11021 partially protects rat kidneys from cold storage and transplantation-induced mitochondrial and renal injury (2020)
    Archives of Biochemistry and Biophysics 7 citations DOI OpenAlex
  • Targeting Mitochondria during Cold Storage to Maintain Proteasome Function and Improve Renal Outcome after Transplantation (2020)
    International Journal of Molecular Sciences 15 citations DOI OpenAlex
  • Cold Storage Increases Albumin and Advanced Glycation-End Product-Albumin Levels in Kidney Transplants: A Possible Cause for Exacerbated Renal Damage (2019)
    Transplantation Direct 10 citations DOI OpenAlex
  • Renal cold storage followed by transplantation impairs proteasome function and mitochondrial protein homeostasis (2018)
    American Journal of Physiology-Renal Physiology 22 citations DOI OpenAlex
  • Albumin Level in Transplanted Kidneys is Higher inThose That Underwent Cold Storage BeforeTransplantation (2018)
    Biomedical Journal of Scientific & Technical Research DOI OpenAlex

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Collaboration Network

18 Collaborators 4 Institutions 1 Country

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