Jianhui Chang

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UAMS

Also affiliated: Australian National University (2022); National Institutes of Health (2005); IBM (United States) (1988); Guangdong University of Technology (2024); Central South University (2020–2025); Chinese Academy of Medical Sciences & Peking Union Medical College (2011–2012); Hong Kong University of Science and Technology (2024); Peking University (2005–2024); Inner Mongolia University (2024); University of Michigan (2005); Southern University of Science and Technology (2020–2022); National Institute of Dental and Craniofacial Research (2005); Nanjing Drum Tower Hospital (2025); IBM Research - Thomas J. Watson Research Center (1988); China Telecom (China) (2025–2026); Peng Cheng Laboratory (2021); China Telecom (2024–2026); State Key Laboratory of Pharmaceutical Biotechnology (2025); China University of Mining and Technology - Beijing (2018–2019); The Hong Kong University of Science and Technology (Guangzhou) (2024); Shanghai Ocean University (2024); Xiangtan University (2018); Kanagawa Dental University (2005); Nanjing University (2025)

32 h-index 103 pubs 6,547 cited

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OverviewAI-generated summary

Jianhui Chang's research focuses on cellular senescence, aging, and the impact of various interventions on stem cell function and tissue injury. Chang has investigated the role of cellular senescence in promoting adverse effects of chemotherapy and contributing to cancer relapse. Studies have explored methods to clear senescent cells, such as using ABT263, to rejuvenate aged hematopoietic stem cells in mice. Additionally, Chang has examined the potential of proteolysis-targeting chimera technology to mitigate drug toxicity and enhance senolytic activity.

Further research has involved evaluating natural compounds, like resveratrol and piperlongumine, for their ability to ameliorate long-term hematopoietic stem cell injury induced by ionizing irradiation and for their potential as senolytic agents. Chang's work also touches upon the molecular mechanisms underlying age-related changes, such as the decrease in osteoprogenitors with age due to DNA damage and senescence. The researcher's publication record includes work on diverse topics, such as information-flow security and flexible perovskite solar cells.