Jia‐Long Fang
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Researcher
Also affiliated: Jiangnan University (2023–2025); Pennsylvania State University (2006); United States Food and Drug Administration (2000–2025); Illinois College (2013); University of South Florida (2004); Biochemical Society (2010–2015); Karolinska Institutet (1995–1999); Moffitt Cancer Center (2002–2004); Suzhou University of Science and Technology (2018); In-Q-Tel (2015); University of Illinois Chicago (2013); Chinese Preventive Medicine Association (1995); Integrated Cardio Metabolic Centre (1994); Food and Drug Administration (2008); State Key Laboratory of Food Science and Technology (2023–2025)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Jia-Long Fang investigates the toxicological effects and biological mechanisms of various chemical compounds, with a focus on potential carcinogenicity, metabolic disorders, and cellular responses. His research has examined the carcinogenicity of dyes such as gentian violet and malachite green, and the toxicity of polyethylene glycols in animal models. Fang has also explored the role of specific molecular pathways, including the thromboxane A2/thromboxane A2 receptor axis, in the development of hepatic insulin resistance and steatosis associated with non-alcoholic fatty liver disease. This work has led to the investigation of natural compounds like piperlongumine and ginkgolide B as potential therapeutic agents for ameliorating these conditions by targeting these pathways.
Further research by Fang delves into the metabolic transformations of compounds, such as the oxidation of 7-hydroxycannabidiol to a reactive metabolite by NAD(P)+-dependent alcohol oxidoreductases. His work also encompasses the impact of microbial metabolites, like indole-3-lactic acid produced by Lactiplantibacillus plantarum, on mitigating oxidative stress and intestinal aging. Fang's research network includes consistent collaborations with researchers at the National Center for Toxicological Research, including Frederick A. Beland, Mackean P. Maisha, Michelle M. Vanlandingham, and Robert P. Felton. With an h-index of 30 and over 3,187 citations across 65 publications, Fang is recognized as a highly cited researcher.
Metrics
- h-index: 30
- Publications: 65
- Citations: 3,214
Selected Publications
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Contribution of cytochrome P450-mediated metabolism to clavulanic acid-induced cytotoxicity in TK6-derived cytochrome P450-overexpressing cell lines (2026)
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NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite (2025)
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Flow cytometric analysis of the SARS coronavirus 2 antibodies in human plasma (2025)
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Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice (2023)
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Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination (2023)
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Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination (2023)
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Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats (2022)
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Flow cytometry analysis of anti-polyethylene glycol antibodies in human plasma (2020)
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Apoptosis contributes to the cytotoxicity induced by amodiaquine and its major metabolite N-desethylamodiaquine in hepatic cells (2019)
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Role of peroxisome proliferator-activated receptor alpha (PPARα) and PPARα-mediated species differences in triclosan-induced liver toxicity (2018)
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Effects of human sulfotransferases on the cytotoxicity of 12-hydroxynevirapine (2018)
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Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells (2016)
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Effect of triclosan, triclocarban, 2,2′,4,4′-tetrabromodiphenyl ether, and bisphenol A on the iodide uptake, thyroid peroxidase activity, and expression of genes involved in thyroid hormone synthesis (2016)
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Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan (2015)
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Mechanisms of tolvaptan-induced toxicity in HepG2 cells (2015)
Collaboration Network
Top Collaborators
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- NAD(P)+-dependent alcohol oxidoreductases oxidize 7-hydroxycannabidiol to a reactive formyl metabolite
- Flow cytometric analysis of the SARS coronavirus 2 antibodies in human plasma
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
- Two-year dermal carcinogenicity bioassay of triclosan in B6C3F1 mice
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
- Evaluation of association of anti-PEG antibodies with anaphylaxis after mRNA COVID-19 vaccination
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