Fen Xia

Federal Grant PI High Impact

Department Chairperson

UAMS

Faculty Researcher

Department Chairs, College of Medicine

40 h-index 176 pubs 6,459 cited

Research Areas

Biomedical Subjects

Links

Lab Website Research Group UAMS TRI Profile

OverviewAI-generated summary

Fen Xia's research focuses on the DNA damage response and repair mechanisms, particularly in the context of cancer treatment and chemotherapy-induced toxicities. Xia serves as PI on two NIH/National Cancer Institute grants totaling $955,860. One grant, for $326,880, investigates the role of Sirtuin 2 in regulating transcription-associated DNA damage repair. The second grant, for $628,980, explores the GSK3β-53BP1 axis in immune control of solid tumor progression. Xia's work has also examined the role of nucleotide excision repair in cisplatin-induced peripheral neuropathy and the impact of nicotinamide riboside on this condition via SIRT2 activation.

Metrics

h-index: 40
Publications: 176
Citations: 6,459

Selected Publications

SIRT2 mitigates radiation-induced oral mucositis by promoting homologous recombination-mediated DNA double-strand break repair in epithelial stem cells (2026)

Cancer Letters DOI OpenAlex
GSK3B directs DNA repair choice and determines tumor response to PARP1 inhibition independent of BRCA1 (2025)

Journal of Clinical Investigation 1 citation DOI OpenAlex
236 Manipulating the DNA damage response to combat T cell exhaustion and improve immunotherapy response (2025)

Regular and Young Investigator Award Abstracts DOI OpenAlex
Grid Spatially Fractionated Radiation Therapy for Bulky Tumors: A Large Single Institution Experience (2025)

International Journal of Radiation Oncology*Biology*Physics 4 citations DOI OpenAlex
Producing high quality cranial SRS plans with 4Pi planning technique in a commercial clinical solution (2025)

Journal of Applied Clinical Medical Physics DOI OpenAlex
Sirt2 Mitigates Radiation-Induced Oral Mucositis by Promoting Homologous Recombination-Mediated DNA Double-Strand Break Repair in Epithelial Stem Cells (2025)

SSRN Electronic Journal 1 citation DOI OpenAlex
376 Inhibition of GSK3β-mediated 53BP1 T334 phosphorylation in T cells enhances infiltration and cytotoxicity against head and neck squamous cell carcinoma (2024)

Regular and Young Investigator Award Abstracts DOI OpenAlex
Spatially Fractionated Radiotherapy GRID for Bulky Tumor: A Large Single Institution Experience (2024)

International Journal of Radiation Oncology*Biology*Physics 2 citations DOI OpenAlex
Abstract PR011: Novel role of glycogen synthase kinase-3β in determining cancer cell response to PARPi through regulation of 53BP1 function (2024)

Cancer Research DOI OpenAlex
A Prospective Study Measuring Resident and Faculty Contour Concordance: A Potential Tool for Quantitative Assessment of Residents’ Performance in Contouring and Target Delineation in Radiation Oncology Residency (2023)

Journal of the American College of Radiology 6 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 2 $955,860 total

NIH Contact PI May 2026 - Apr 2031

Exploring host GSK3β-53BP1 axis in immune control of solid tumor progression

National Cancer Institute $628,980 R01

NIH Contact PI Apr 2020 - Sep 2026

The novel role of Sirtuin 2 in regulation of transcription-associated DNA damage repair

National Cancer Institute $326,880 R01

Grants & Funding

As listed on this researcher's institutional profile. Federal awards with verified records are shown above.

A Prospective Trial of Stereotactic Adaptive Radiation Therapy for Borderline Resectable/Locally Advanced Pancreatic Cancer: An Individualized Approach to Minimizing Gastrointestinal Toxicity (ARTIA-Pancreas) Varian Medical Systems Principal Investigator
Novel functions of Pyruvate kinase M2 in DNA double-strand break repair NIH/NCI Principal Investigator
GSK3b mediates radiation-induced cytotoxicity in hippocampal neurons NIH Principal Investigator
Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator
Novel functions of Pyruvate kinase M2 in DNA double-strand break repair NIH Principal Investigator
The role of BRCA1 in nonhomologous repair of chromosomal double-strand breaks NIH Principal Investigator
A Phase 3 Randomized Controlled Trial of Post-Surgical Stereotactic Radiotherapy (SRT)versus Surgically Targeted Radiation Therapy (STaRT) with Gamma Tile for Treatment of Newly Diagnosed Metastatic Brain Tumors. GT Medical Technologies, Inc. Principal Investigator