Match tier Listed
Presence Current · Arkansas
Last published 2024
Sources OpenAlex · ORCID
Refreshed 2026-08-08

Clara M. Stiefel

Researcher

UAMS

Also affiliated: University of Kaiserslautern (2021); The University of Texas at San Antonio Health Science Center (2023)

Unknown Researcher

4 h-index 5 pubs 145 cited

Research Areas

Biomedical Subjects

  • Trisomy
  • DNA Damage
  • Humans
  • DNA Repair
  • DNA Breaks, Double-Stranded
  • Down Syndrome
  • STING Protein
  • Cyclic Guanosine Monophosphate-Adenosine Monophosphate Synthase
  • Autophagy
  • Cell Line
  • Cells, Cultured
  • Gene Expression Regulation
  • Immunity, Innate
  • Membrane Proteins
  • Nucleotidyltransferases

OverviewAI-generated summary

Clara M. Stiefel's research focuses on the molecular mechanisms underlying genetic disorders and DNA damage repair. Her work investigates how constitutive trisomies, such as Down Syndrome, trigger cellular responses including autophagy and innate immune activation through the cGAS-STING pathway. She has also explored the role of specific nucleases, like APE2, in essential DNA double-strand break repair processes, specifically microhomology-mediated end joining. Further investigations have examined genetic variations, such as a rare SNP in the HELB gene, and their impact on protein interactions and cellular function. Stiefel collaborates with researchers at the University of Arkansas for Medical Sciences, including Maroof K. Zafar, Eric J. Enemark, Alicia K. Byrd, and Matthew D. Thompson, with whom she has co-authored publications. Her scholarship metrics include an h-index of 4, with 5 total publications and 144 total citations.

Metrics

  • h-index: 4
  • Publications: 5
  • Citations: 145

Selected Publications

  • Rare SNP in the <i>HELB</i> gene interferes with RPA interaction and cellular function of HELB (2024)
    bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
  • Consequences of chromosome gain: A new view on trisomy syndromes (2022)
    The American Journal of Human Genetics 43 citations DOI OpenAlex
  • The APE2 nuclease is essential for DNA double strand break repair by microhomology-mediated end-joining (2022)
    bioRxiv (Cold Spring Harbor Laboratory) 5 citations DOI OpenAlex

View all publications on OpenAlex →

Collaboration Network

22 Collaborators 9 Institutions 3 Countries

Top Collaborators

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