Match tier
Likely match
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
G
Gonçalo Gamboa da Costa
This is a likely match — the affiliation was inferred from OpenAlex, ORCID, and web sources but has not been fully confirmed. Treat with appropriate caution.
High Impact
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31 h-index
100 pubs
2,790 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Gonçalo Gamboa da Costa's research focuses on the mechanisms of chemical toxicity, particularly the formation and persistence of DNA adducts. His work investigates how compounds like acrylamide, glycidamide, and aristolochic acid interact with DNA, leading to potential genotoxicity and long-term health effects. He has examined these processes in various mammalian models, including mice and rats, and has also investigated human tissue samples.
His research group has explored the metabolic activation and detoxification pathways of xenobiotics, utilizing techniques such as high-pressure liquid chromatography and mass spectrometry. This includes studying the role of cytochrome P450 enzymes in the metabolism of substances like benzo[a]pyrene and isoflavones. Gamboa da Costa's work has also addressed the CLARITY-BPA research program, investigating the toxicological effects of Bisphenol A.
With over 100 publications and an h-index of 31, his scholarship is recognized as highly cited. He collaborates with researchers at the National Center for Toxicological Research, including Frederick A. Beland, Michelle M. Vanlandingham, Kellie A. Woodling, and Volodymyr Tryndyak. Gamboa da Costa leads a research group and remains actively engaged in his field.
Metrics
- h-index: 31
- Publications: 100
- Citations: 2,790
Selected Publications
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Physiologically based pharmacokinetic modeling of oseltamivir in pregnant rhesus macaques to inform clinical dosing across trimesters (2025)
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Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025)
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Pharmacokinetics of cannabidiol and its metabolites in rhesus monkeys and New Zealand White rabbits (2025)
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Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025)
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Considerations from the pharmaceutical industry (IQ MPS affiliate) workshop on animal microphysiological systems and 3Rs in drug development (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Trust your gut: Establishing confidence in gastrointestinal models - An overview of the state of the science and contexts of use (2024)
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The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model (2024)
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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
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Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats (2022)
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Effects of Serum and Compound Preparation Methods on Delayed Repolarization Evaluation With Human iPSC-CMs (2022)
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Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats (2022)
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Effect of urinary pH upon the renal toxicity of melamine and cyanuric acid (2021)
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A rapid and highly sensitive UPLC-ESI-MS/MS method for the analysis of the fatty acid profile of edible vegetable oils (2020)
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Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts (2020)
Collaboration Network
Top Collaborators
Frederick A. Beland
National Center for Toxicological Research
32 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- Absorption and metabolism of triclosan after application to the skin of B 6 C 3 F 1 mice
Showing 5 of 32 shared publications
M. Matilde Marques
National Center for Toxicological Research (US)
14 shared publications
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
Showing 5 of 14 shared publications
Daniel R. Doerge
National Center for Toxicological Research
13 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Showing 5 of 13 shared publications
Luísa Camacho
National Center for Toxicological Research
12 shared publications
In database
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats
- Gene expression of biomarkers of nephrotoxicity in F344 rats co-exposed to melamine and cyanuric acid for seven days
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
Showing 5 of 12 shared publications
Mona I. Churchwell
National Center for Toxicological Research
12 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- NIEHS/FDA CLARITY-BPA research program update
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Pyrrolizidine Alkaloid-Derived DNA Adducts in Vitro and in Vivo
Showing 5 of 12 shared publications
Linda S. Von Tungeln
National Center for Toxicological Research
11 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats
- DNA adduct formation and induction of micronuclei and mutations in B6C3F1/Tk mice treated neonatally with acrylamide or glycidamide
- Dose–response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats
Showing 5 of 11 shared publications
Kellie A. Woodling
National Center for Toxicological Research
10 shared publications
In database
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Intrinsic Resistance of Burkholderia cepacia Complex to Benzalkonium Chloride
- Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: Gavage vs. feeding
- Developmental neurotoxicity of inorganic arsenic exposure in Sprague-Dawley rats
Showing 5 of 10 shared publications
Cristina C. Jacob
National Center for Toxicological Research (US)
10 shared publications
- Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats
- Dose–response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats
- Pharmacokinetics of Melamine and Cyanuric Acid and Their Combinations in F344 Rats
- Urinary Biomarker Detection of Melamine- and Cyanuric Acid-Induced Kidney Injury in Rats
- Low-level quantification of melamine and cyanuric acid in limited samples of rat serum by UPLC–electrospray tandem mass spectrometry
Showing 5 of 10 shared publications
Michelle M. Vanlandingham
National Center for Toxicological Research
9 shared publications
In database
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Absorption and metabolism of triclosan after application to the skin of B 6 C 3 F 1 mice
- Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats
- Toxicity of high-molecular-weight polyethylene glycols in Sprague Dawley rats
Showing 5 of 9 shared publications
David H. Phillips
King's College London (GB)
8 shared publications
- Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice
- Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy
- Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts
- Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry
- Mutagenic potential of nitrenium ions of nitrobenzanthrones: Correlation between theory and experiment
Showing 5 of 8 shared publications
Volker Manfred Arlt
King's College London (GB)
8 shared publications
- Metabolic activation of benzo[a]pyrene in vitro by hepatic cytochrome P450 contrasts with detoxification in vivo: experiments with hepatic cytochrome P450 reductase null mice
- Exceptionally long-term persistence of DNA adducts formed by carcinogenic aristolochic acid I in renal tissue from patients with aristolochic acid nephropathy
- Mutagenicity of acrylamide and glycidamide in human TP53 knock-in (Hupki) mouse embryo fibroblasts
- Detection and quantitation of N-(deoxyguanosin-8-yl)-2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine adducts in DNA using online column-switching liquid chromatography tandem mass spectrometry
- Mutagenic potential of nitrenium ions of nitrobenzanthrones: Correlation between theory and experiment
Showing 5 of 8 shared publications
Lucie Loukotková
National Center for Toxicological Research
8 shared publications
In database
- Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells
- Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: Gavage vs. feeding
- A simple and highly sensitive UPLC-ESI-MS/MS method for the simultaneous quantification of nicotine, cotinine, and the tobacco-specific carcinogens N’-nitrosonornicotine and 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone in serum samples
- Developmental neurotoxicity of inorganic arsenic exposure in Sprague-Dawley rats
- Pharmacokinetics of oseltamivir phosphate and oseltamivir carboxylate in non-pregnant and pregnant rhesus monkeys
Showing 5 of 8 shared publications
Priyanka Chitranshi
National Center for Toxicological Research
7 shared publications
In database
- Functional characterization of the water-soluble organic carbon of size-fractionated aerosol in the southern Mississippi Valley
- Cytochrome P450-mediated metabolism of triclosan attenuates its cytotoxicity in hepatic cells
- Human Sulfotransferases Enhance the Cytotoxicity of Tolvaptan
- Effects of human sulfotransferases on the cytotoxicity of 12-hydroxynevirapine
- Toxicological evaluation of brominated vegetable oil in Sprague Dawley rats
Showing 5 of 7 shared publications
K. Barry Delclos
National Center for Toxicological Research
6 shared publications
In database
- NIEHS/FDA CLARITY-BPA research program update
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
- Effects of oral exposure to bisphenol A on gene expression and global genomic DNA methylation in the prostate, female mammary gland, and uterus of NCTR Sprague-Dawley rats
- Comparison of endpoints relevant to toxicity assessments in 3 generations of CD-1 mice fed irradiated natural and purified ingredient diets with varying soy protein and isoflavone contents
- The effect of black cohosh extract and risedronate coadministration on bone health in an ovariectomized rat model
Showing 5 of 6 shared publications
Renate Reimschuessel
Center for Veterinary Medicine (US)
6 shared publications
- Dose-Response Assessment of Nephrotoxicity from a 7-Day Combined Exposure to Melamine and Cyanuric Acid in F344 Rats
- Dose–response assessment of nephrotoxicity from a twenty-eight-day combined-exposure to melamine and cyanuric acid in F344 rats
- A No Observable Adverse Effects Level (NOAEL) for pigs fed melamine and cyanuric acid
- Timing and route of exposure affects crystal formation in melamine and cyanuric exposed male and female rats: Gavage vs. feeding
- Performance of urinary and gene expression biomarkers in detecting the nephrotoxic effects of melamine and cyanuric acid following diverse scenarios of co-exposure
Showing 5 of 6 shared publications
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