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Listed
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
D
Dean W. Roberts
High Impact
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Also affiliated: University of Copenhagen (1990); Arkansas Children's Hospital (2008–2016); United States Food and Drug Administration (1982–2009); University of Kentucky (1994); University of California, San Francisco (2009); Medical College of Wisconsin (2009); University of Arkansas Medical Center (1993–2012); Rigshospitalet (1990); University of California San Diego (2009); PAREXEL International (United States) (2012); Instituto Superior Técnico (2002–2004); Centro de Química Estrutural (2002–2004); Arkansas Children's Research Institute (2008–2015); Trinity College (1986); The University of Texas Southwestern Medical Center (2009)
33 h-index
81 pubs
4,223 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Dean W. Roberts' research focuses on the study of acetaminophen toxicity, specifically investigating the development of clinical assays for the determination of acetaminophen protein adducts. His work has also explored the history of acetaminophen toxicity studies.
Roberts is a highly cited researcher with a scholarly output including 116 publications and over 4,300 citations, contributing to a h-index of 34. His recent publications include work on the COVID-19 outbreak at Mission Medium federal penitentiary, alongside his research on acetaminophen. He has collaborated with other researchers at the University of Arkansas for Medical Sciences, including Mitchell R. McGill and Laura P. James, with whom he shares publications.
Metrics
- h-index: 33
- Publications: 81
- Citations: 4,223
Selected Publications
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Development of clinical assays for determination of acetaminophen protein adducts (2024)
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History of acetaminophen toxicity studies (2024)
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Advances in biomarker development in acetaminophen toxicity (2020)
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Acetaminophen is both bronchodilatory and bronchoprotective in human precision cut lung slice airways (2018)
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An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure (2016)
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Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures (2015)
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High Dose Acetaminophen Fails to Promote Airway Hyper-Reactivity Ex Vivo and Is Both Bronchoprotective and Bronchodilatory (2015)
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Isoniazid hepatotoxicity: Progress in understanding the immunologic component (2013)
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Mouse Liver Protein Sulfhydryl Depletion after Acetaminophen Exposure (2012)
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Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations (2012)
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A Novel Defensive Mechanism against Acetaminophen Toxicity in the Mouse Lateral Nasal Gland: Role of CYP2A5-Mediated Regulation of Testosterone Homeostasis and Salivary Androgen-Binding Protein Expression (2011)
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The proper use of acetaminophen (2011)
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Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure (2009)
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Quantitative Determination of Skin Penetration of PEG-Coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin (2009)
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Immunotoxicity of Cephalosporins in Mice (2009)
Collaboration Network
Top Collaborators
Robert W. Benson
National Center for Toxicological Research (US)
18 shared publications
- Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.
- Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
- Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice
- HepG2 Cells: An in Vitro Model for P450-Dependent Metabolism of Acetaminophen
- Mechanism of paracetamol toxicity
Showing 5 of 18 shared publications
Jack Hinson
University of Arkansas for Medical Sciences
12 shared publications
In database
- Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
- Mechanisms of Acetaminophen Toxicity: Immunochemical Detection of Drug-Protein Adducts
- Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice
- An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure
- Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen
Showing 5 of 12 shared publications
Laura Phillips James
University of Arkansas for Medical Sciences
10 shared publications
In database
- Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
- An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure
- Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
- The proper use of acetaminophen
- Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures
Showing 5 of 10 shared publications
Neil R. Pumford
University of Arkansas for Medical Sciences (US)
7 shared publications
- Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.
- Mechanisms of Acetaminophen Toxicity: Immunochemical Detection of Drug-Protein Adducts
- Immunoblot analysis of protein containing 3-(cystein-S-yl)acetaminophen adducts in serum and subcellular liver fractions from acetaminophen-treated mice
- Immunochemical quantitation of 3-(cystein-S-yl)acetaminophen protein adducts in subcellular liver fractions following a hepatotoxic dose of acetaminophen
- Epitope characterization of acetaminophen bound to protein and nonprotein sulfhydryl groups by an enzyme-linked immunosorbent assay.
Showing 5 of 7 shared publications
Fred F. Kadlubar
United States Food and Drug Administration (US)
5 shared publications
- Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl–DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation
- Alkyl and aryl carcinogen adducts detected in human peripheral lung
- Lactoperoxidase-Catalyzed Activation of Carcinogenic Aromatic and Heterocyclic Amines
- Immunochemical quantitation of DNA adducts derived from the human bladder carcinogen 4-aminobiphenyl.
- Critical considerations in the immunochemical detection and quantitation of antigenic biomarkers.
Daniel R. Doerge
National Center for Toxicological Research
5 shared publications
In database
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Quantitative Analysis of Etheno-2‘-Deoxycytidine DNA Adducts Using On-Line Immunoaffinity Chromatography Coupled With LC/ES-MS/MS Detection
- On-Line Immunoaffinity Capture, Coupled with HPLC and Electrospray Ionization Mass Spectrometry, for Automated Determination of Fumonisins
Lynda G. Letzig
University of Arkansas for Medical Sciences (US)
5 shared publications
- Pharmacokinetics of Acetaminophen-Protein Adducts in Adults with Acetaminophen Overdose and Acute Liver Failure
- Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose
- An Immunoassay to Rapidly Measure Acetaminophen Protein Adducts Accurately Identifies Patients With Acute Liver Injury or Failure
- Acetaminophen protein adduct formation following low-dose acetaminophen exposure: comparison of immediate-release vs extended-release formulations
- Cooperativity in CYP2E1 metabolism of acetaminophen and styrene mixtures
J. A. Hinson
National Center for Toxicological Research (US)
4 shared publications
- Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.
- Acetaminophen-Associated Hepatic Injury: Evaluation of Acetaminophen Protein Adducts in Children and Adolescents With Acetaminophen Overdose
- Mechanism of paracetamol toxicity
- Acetaminophen-induced alterations in pancreatic β cells and serum insulin concentrations in B6C3F1 mice
Mona I. Churchwell
National Center for Toxicological Research
4 shared publications
In database
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Quantitative Analysis of Etheno-2‘-Deoxycytidine DNA Adducts Using On-Line Immunoaffinity Chromatography Coupled With LC/ES-MS/MS Detection
- On-Line Immunoaffinity Capture, Coupled with HPLC and Electrospray Ionization Mass Spectrometry, for Automated Determination of Fumonisins
George L. Wolff
National Center for Toxicological Research (US)
4 shared publications
- Physiological consequences of ectopicagoutigene expression: the yellow obese mouse syndrome
- Prenatal determination of obesity, tumor susceptibility, and coat color pattern in viable yellow (Avy/a) mice
- Tumorigenic responses to lindane in mice: potentiation by a dominant mutation
- Differential effects of the mottled yellow and pseudoagouti phenotypes on immunocompetence in Avy/a mice.
Paul C. Howard
National Center for Toxicological Research
4 shared publications
In database
- Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice
- Quantitative Determination of Skin Penetration of PEG-Coated CdSe Quantum Dots in Dermabraded but not Intact SKH-1 Hairless Mouse Skin
- On-Line Immunoaffinity Capture, Coupled with HPLC and Electrospray Ionization Mass Spectrometry, for Automated Determination of Fumonisins
- Identification of fumonisin B1 as an inhibitor of argininosuccinate synthetase using fumonisin affinity chromatography and in vitro kinetic studies
JOHN E. SNAWDER
National Center for Toxicological Research (US)
4 shared publications
- Repeat Exposure to Incremental Doses of Acetaminophen Provides Protection Against Acetaminophen–Induced Lethality in Mice: An Explanation for High Acetaminophen Dosage in Humans Without Hepatic Injury
- HepG2 Cells: An in Vitro Model for P450-Dependent Metabolism of Acetaminophen
- Immunochemical, 32P-postlabeling, and GC/MS detection of 4-aminobiphenyl–DNA adducts in human peripheral lung in relation to metabolic activation pathways involving pulmonary N-oxidation, conjugation, and peroxidation
- The effect of propylene glycol on the P450-dependent metabolism of acetaminophen and other chemicals in subcellular fractions of mouse liver
Thomas J. Bucci
Associates in Neurology (US)
3 shared publications
- Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.
- Acetaminophen-induced alterations in pancreatic β cells and serum insulin concentrations in B6C3F1 mice
- Immunohistochemical Detection of Antigenic Biomarkers in Microwave-Fixed Target Tissues
Alan R. Warbritton
Associates in Neurology (US)
3 shared publications
- Immunohistochemical localization and quantification of the 3-(cystein-S-yl)-acetaminophen protein adduct in acetaminophen hepatotoxicity.
- Migration of Intradermally Injected Quantum Dots to Sentinel Organs in Mice
- Immunohistochemical Detection of Antigenic Biomarkers in Microwave-Fixed Target Tissues
William H. Tolleson
National Center for Toxicological Research
3 shared publications
In database
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Identification of fumonisin B1 as an inhibitor of argininosuccinate synthetase using fumonisin affinity chromatography and in vitro kinetic studies
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