Yuet‐Kin Leung

High Impact

Associate Professor

University of Arkansas for Medical Sciences

faculty

Pharmacology & Toxicology, College of Medicine

40 h-index 144 pubs 5,434 cited

Research Areas

Cancer-related molecular mechanisms research Pharmacological Effects and Toxicity Studies Epigenetics and DNA Methylation Metabolomics and Mass Spectrometry Studies Birth, Development, and Health Carcinogens and Genotoxicity Assessment Health and Medical Research Impacts

Links

ORCID Lab Website Research Group UAMS TRI Profile

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OverviewAI-generated summary

Yuet‐Kin Leung's research focuses on understanding the mechanisms of disease and developing potential therapeutic interventions, with a particular emphasis on cancer and environmental health. His work investigates the role of specific molecular targets in cancer development and progression, exploring inhibitors for key signaling pathways implicated in diseases like acute myeloid leukemia and hepatocellular carcinoma. This includes the discovery and optimization of novel chemical derivatives designed to target FLT3, FLT3 mutants, and RET kinase, as detailed in his recent publications.

In parallel, Leung's research extends to the impact of environmental exposures on human health, particularly during critical developmental periods such as gestation. His studies examine how environmental chemicals can lead to epigenetic alterations in the placenta and cord blood, and investigate the intergenerational effects of paternal exposure to substances like arsenic on sperm quality and subsequent offspring health. This body of work contributes to understanding the complex interplay between environmental factors and long-term health outcomes, including potential impacts on reproductive health and the development of chronic diseases.

Leung holds an h-index of 40 with over 5,400 citations across 144 publications. He is a Co-PI on a $468,131 NIH/National Institute of Environmental Health Sciences grant examining RNA modifications by paternal exposure to arsenic and their intergenerational effects. He collaborates with several researchers at the University of Arkansas for Medical Sciences, including Brendan Frett, Anupreet Kharbanda, Phuc Tran, and Xiuqi Wang, with whom he has co-authored multiple publications.

Metrics

  • h-index: 40
  • Publications: 144
  • Citations: 5,434

Selected Publications

  • Epigenetic signatures of maternal-fetal health: insights from cord blood and placenta (2025) DOI
  • Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns (2025) DOI
  • Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024) DOI
  • Endocrine-Disrupting Chemicals: A Looming Threat to Current and Future Generations (2024) DOI
  • Gestational exposure to environmental chemicals and epigenetic alterations in the placenta and cord blood mononuclear cells (2024) DOI
  • The Loss of an Orphan Nuclear Receptor NR2E3 Augments Wnt/β‐catenin Signaling via Epigenetic Dysregulation that Enhances Sp1‐β catenin‐p300 Interactions in Hepatocellular Carcinoma (2024) DOI
  • Abstract 3011: The loss of an orphan nuclear receptor NR2E3 augments Wnt/β-Catenin signaling via epigenetic dysregulation that links to the Sp1-β catenin-p300 interactions in hepatocellular carcinoma (2024) DOI
  • Abstract 6282: Novel androgen related gene network in prostate cancer cell model (2024) DOI
  • Maternal and newborn metabolomic changes associated with urinary polycyclic aromatic hydrocarbon metabolite concentrations at delivery: an untargeted approach (2023) DOI
  • An imidazo[1,2-a]pyridine-pyridine derivative potently inhibits FLT3-ITD and FLT3-ITD secondary mutants, including gilteritinib-resistant FLT3-ITD/F691L (2023) DOI
  • Stem Cell Theory of Cancer: Clinical Implications of Epigenomic versus Genomic Biomarkers in Cancer Care (2023) DOI
  • N-(3-Methoxyphenyl)-6-(7-(1-methyl-1H-pyrazol-4-yl)imidazo[1,2-a]pyridin-3-yl)pyridin-2-amine is an inhibitor of the FLT3-ITD and BCR-ABL pathways, and potently inhibits FLT3-ITD/D835Y and FLT3-ITD/F691L secondary mutants (2023) DOI
  • A Silent Threat: Exploring the Impact of Endocrine Disruption on Human Health (2023) DOI
  • Discovery of N-Trisubstituted Pyrimidine Derivatives as Type I RET and RET Gatekeeper Mutant Inhibitors with a Novel Kinase Binding Pose (2022) DOI
  • The androgen receptor inhibits transcription of GPER1 by preventing Sp1 and Sp3 from binding to the promoters in prostate cancer cells (2021) DOI

Federal Grants 1 $468,131 total

NIH/National Institute of Environmental Health Sciences Co-PI Apr 2022 - Jan 2027

RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality

National Institute of Environmental Health Sciences $468,131 R01

Grants & Funding

  • DNA methylation markers associated with exposure and adverse health outcomes in Veterans exposed to airborne hazards from open burn pits DOD Co-Investigator
  • NSF, RII Track-2 FEC: Facilitating Ubiquitous Technology Utilizing Resilient Eco-friendly Sensors (FUTURE Sensors) National Science Foundation - Pass Through: Louisiana Tech University Co-Investigator
  • RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality NIH Principal Investigator
  • RNA modifications by paternal exposure to arsenic and intergenerational effects on sperm quality NIH/Nat. Inst. of Environmental Health Sciences Principal Investigator

Collaborators

Researchers in the database who share publications

Brendan Frett University of Arkansas for Medical Sciences 4 shared publications Anupreet Kharbanda University of Arkansas for Medical Sciences 4 shared publications Phuc Tran University of Arkansas for Medical Sciences 4 shared publications Xiuqi Wang University of Arkansas for Medical Sciences 4 shared publications Kyounghyun Kim University of Arkansas for Medical Sciences 3 shared publications Neville N.C. Tam University of Arkansas for Medical Sciences 2 shared publications Nancy Rusch University of Arkansas for Medical Sciences 2 shared publications Jaideep B. Bharate University of Arkansas for Medical Sciences 2 shared publications

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