B
Barbara L. Parsons Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Microbiogist
faculty
29 h-index
144 pubs
2,744 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Barbara L. Parsons is a research microbiologist whose work focuses on the application of advanced sequencing technologies for genotoxicity and cancer risk assessment. Her research investigates the detection and interpretation of genetic mutations, particularly small variants of low allele frequency, in the context of carcinogenicity testing. Parsons has published extensively on the development and validation of error-corrected next-generation sequencing methods, highlighting their potential to improve the accuracy and sensitivity of nonclinical genotoxicity and carcinogenicity testing.
Her recent publications explore the performance of cancer gene panels, the measurement of cancer driver mutations in animal models, and the correlation of these mutations with spontaneous tumor incidence. Parsons also contributes to the interpretation of in vitro concentration-response data for regulatory decision-making, emphasizing the quantitative analysis of experimental results. She has a notable publication record with 147 total publications and an h-index of 29, with 2,850 total citations. Parsons actively collaborates with researchers at the National Center for Toxicological Research, including Meagan B. Myers, Robert H. Heflich, Binsheng Gong, and Kelly L. Harris.
Metrics
- h-index: 29
- Publications: 144
- Citations: 2,744
Selected Publications
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Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in <scp>rasH2</scp> ‐Tg Mice (2025)
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Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing (2025)
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Clonal expansion of cancer driver gene mutants investigated using advanced sequencing technologies (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue (2024)
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<scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>) (2024)
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Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq (2024)
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Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 <scp>IWGT</scp> quantitative analysis expert working group meeting (2023)
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Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment (2023)
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Interpretation of In Vitro Concentration-Response Data for Risk Assessment and Regulatory Decision-making: Report from 2022 IWGT Quantitative Analysis Expert Working Group Meeting (2023)
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Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing (2023)
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Launching the “Projections” series in mutation research reviews with a special issue on next generation sequencing (2021)
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Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia (2021)
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A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency (2021)
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Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions (2021)
Collaboration Network
Top Collaborators
Meagan B. Myers
United States Food and Drug Administration
7 shared publications
In database
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- <scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>)
Showing 5 of 7 shared publications
Binsheng Gong
National Center for Toxicological Research
6 shared publications
In database
- A verified genomic reference sample for assessing performance of cancer panels detecting small variants of low allele frequency
- Cross-oncopanel study reveals high sensitivity and accuracy with overall analytical performance depending on genomic regions
- CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq
Showing 5 of 6 shared publications
Robert H. Heflich
United States Food and Drug Administration
6 shared publications
In database
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 <scp>IWGT</scp> quantitative analysis expert working group meeting
- <scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>)
- Interpretation of In Vitro Concentration-Response Data for Risk Assessment and Regulatory Decision-making: Report from 2022 IWGT Quantitative Analysis Expert Working Group Meeting
Showing 5 of 6 shared publications
Kelly L. Harris
National Center for Toxicological Research
5 shared publications
In database
- CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq
- Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in <scp>rasH2</scp> ‐Tg Mice
Jennifer Faske
National Center for Toxicological Research
4 shared publications
In database
- CarcSeq detection of lorcaserin-induced clonal expansion of<i>Pik3ca</i>H1047R mutants in rat mammary tissue
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq
- Tissue and Sex‐Specific Performance of a Cancer Driver Based Biomarker in <scp>rasH2</scp> ‐Tg Mice
Joshua Xu
National Center for Toxicological Research
3 shared publications
In database
- CarcSeq Measurement of Rat Mammary Cancer Driver Mutations and Relation to Spontaneous Mammary Neoplasia
- Assessment of Clonal Expansion Using CarcSeq Measurement of Lung Cancer Driver Mutations and Correlation With Mouse Strain- and Sex-Related Incidence of Spontaneous Lung Neoplasia
- Abstract 2440: Cancer driver mutations as quantitative biomarkers of cancer risk interspecies analyses using CarcSeq
Francesco Marchetti
Health Canada (CA)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Connie L. Chen
Health and Environmental Sciences Institute (US)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
George R. Douglas
Health Canada (CA)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- <scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>)
Anthony M. Lynch
Genetic Technologies (Australia) (AU)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- <scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>)
Jesse J. Salk
Blaze Bioscience (United States) (US)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Raja S. Settivari
Corteva (United States) (US)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Stephanie L. Smith‐Roe
Triangle (US)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Carole L. Yauk
University of Ottawa (CA)
3 shared publications
- Error-corrected next generation sequencing – Promises and challenges for genotoxicity and cancer risk assessment
- Error-corrected next-generation sequencing to advance nonclinical genotoxicity and carcinogenicity testing
- Transferability, Reproducibility and Sensitivity of Mutation Quantification by Duplex Sequencing
Marc A. Beal
Health Canada (CA)
3 shared publications
- Interpretation of in vitro concentration‐response data for risk assessment and regulatory decision‐making: Report from the 2022 <scp>IWGT</scp> quantitative analysis expert working group meeting
- <scp>Severity of effect considerations regarding the use of mutation as a toxicological endpoint for risk assessment: A report from the 8th International Workshop on Genotoxicity Testing</scp> (<scp>IWGT</scp>)
- Interpretation of In Vitro Concentration-Response Data for Risk Assessment and Regulatory Decision-making: Report from 2022 IWGT Quantitative Analysis Expert Working Group Meeting
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