Bonnie L. Robinson
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Also affiliated: United States Food and Drug Administration (2000–2023)
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Bonnie Robinson's research focuses on understanding the mechanisms of toxicity and the biological effects of chemical exposures, particularly on the nervous system. Her work utilizes various animal models, including zebrafish and rodents, to investigate how substances like inorganic arsenic and ketamine impact neuronal development and function. Recent publications highlight her investigations into how inorganic arsenic alters dopaminergic and motor neuron development in zebrafish, exploring the underlying pathways such as the Sonic hedgehog pathway. She also examines the potential mechanisms behind the antidepressant actions of ketamine, considering the role of L-type calcium channels.
Further research by Robinson involves the development and application of proteomic approaches to identify circulating biomarkers of neurotoxicity. This work aims to find measurable indicators of central nervous system damage in rodent models. Her collaborations include researchers at the National Center for Toxicological Research, with whom she has co-authored multiple publications, indicating a consistent research network. Robinson's scholarship metrics, including an h-index of 21 and over 1,900 citations, reflect her significant contributions to the field.
Metrics
- h-index: 21
- Publications: 38
- Citations: 1,907
Selected Publications
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Circulating biomarkers of neurotoxicity: Proteomics approach reveals fluidic endpoints of central nervous system toxicity in a rodent model of neurotoxicity (2021)
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Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease (2020)
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N-acetylcysteine prevents verapamil-induced cardiotoxicity with no effect on the noradrenergic arch-associated neurons in zebrafish (2020)
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Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease (2020)
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P4‐064: EVALUATION OF TAU NEUROPATHOLOGY AND OTHER KEY PROTEINS IN THE OLFACTORY BULB AND ITS CORRELATION WITH HIPPOCAMPUS IN HUMAN ALZHEIMER'S DISEASE (2019)
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Nifedipine toxicity is exacerbated by acetyl l ‐carnitine but alleviated by low‐dose ketamine in zebrafish in vivo (2019)
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Ketamine-induced attenuation of reactive oxygen species in zebrafish is prevented by acetyl l-carnitine in vivo (2019)
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Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer’s Disease (2019)
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Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects (2019)
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The time course of blood brain barrier leakage and its implications on the progression of methamphetamine-induced seizures (2018)
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Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease (2018)
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N-acetylcysteine prevents ketamine-induced adverse effects on development, heart rate and monoaminergic neurons in zebrafish (2018)
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Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos (2017)
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Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study (2017)
Collaboration Network
Top Collaborators
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Substance P Exacerbates Dopaminergic Neurodegeneration through Neurokinin-1 Receptor-Independent Activation of Microglial NADPH Oxidase
- Neurotoxic‐related changes in tyrosine hydroxylase, microglia, myelin, and the blood‐brain barrier in the caudate‐putamen from acute methamphetamine exposure
Showing 5 of 22 shared publications
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
Showing 5 of 13 shared publications
- Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles
- Distinct effects of ketamine and acetyl l-carnitine on the dopamine system in zebrafish
- Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos
- Ketamine-induced attenuation of reactive oxygen species in zebrafish is prevented by acetyl l-carnitine in vivo
- Cyclosporine exacerbates ketamine toxicity in zebrafish: Mechanistic studies on drug–drug interaction
Showing 5 of 11 shared publications
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Distinct effects of ketamine and acetyl l-carnitine on the dopamine system in zebrafish
- Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
Showing 5 of 10 shared publications
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects
- Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
Showing 5 of 10 shared publications
- Distinct effects of ketamine and acetyl l-carnitine on the dopamine system in zebrafish
- Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos
- Ketamine-induced attenuation of reactive oxygen species in zebrafish is prevented by acetyl l-carnitine in vivo
- Cyclosporine exacerbates ketamine toxicity in zebrafish: Mechanistic studies on drug–drug interaction
- N-acetylcysteine prevents ketamine-induced adverse effects on development, heart rate and monoaminergic neurons in zebrafish
Showing 5 of 9 shared publications
- Distinct effects of ketamine and acetyl l-carnitine on the dopamine system in zebrafish
- Mechanistic studies on ketamine-induced mitochondrial toxicity in zebrafish embryos
- Ketamine-induced attenuation of reactive oxygen species in zebrafish is prevented by acetyl l-carnitine in vivo
- Cyclosporine exacerbates ketamine toxicity in zebrafish: Mechanistic studies on drug–drug interaction
- N-acetylcysteine prevents ketamine-induced adverse effects on development, heart rate and monoaminergic neurons in zebrafish
Showing 5 of 8 shared publications
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects
- Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease
Showing 5 of 8 shared publications
- Iron Oxide Nanoparticles Induce Dopaminergic Damage: In vitro Pathways and In Vivo Imaging Reveals Mechanism of Neuronal Damage
- Impaired Amyloid Beta Clearance and Brain Microvascular Dysfunction are Present in the Tg-SwDI Mouse Model of Alzheimer’s Disease
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease
- Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer’s Disease
Showing 5 of 7 shared publications
- Tauroursodeoxycholic acid (TUDCA) is neuroprotective in a chronic mouse model of Parkinson’s disease
- Neuroprotective effects of acetyl-l-carnitine (ALC) in a chronic MPTP-induced Parkinson’s disease mouse model: Endothelial and microglial effects
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Identification of altered microRNAs in serum of a mouse model of Parkinson’s disease
- Characterization of Serum Exosomes from a Transgenic Mouse Model of Alzheimer’s Disease
Showing 5 of 7 shared publications
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
Showing 5 of 6 shared publications
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
- Effects of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) on retinal dopaminergic system in mice
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
- Changes in the metabolome and microRNA levels in biological fluids might represent biomarkers of neurotoxicity: A trimethyltin study
- Monoaminergic toxicity induced by cathinone phthalimide: An in vitro study
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
- Silver Nanoparticle Induced Blood-Brain Barrier Inflammation and Increased Permeability in Primary Rat Brain Microvessel Endothelial Cells
- Effects of Copper Nanoparticles on Rat Cerebral Microvessel Endothelial Cells
- Porcine brain microvessel endothelial cells show pro-inflammatory response to the size and composition of metallic nanoparticles
- Brain microvessel endothelial cells responses to gold nanoparticles:In vitropro-inflammatory mediators and permeability
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