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Current · Arkansas
Last published
2023
Sources
OpenAlex · ORCID
Refreshed
2026-10-06
D
Daniel R. Doerge
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Also affiliated: University of Southern California (2007); University of Hawaiʻi at Mānoa (1986–1992); Center for Food Safety and Applied Nutrition (2008); Centers for Disease Control and Prevention (2005); National Institutes of Health (1998–2005); Environmental Protection Agency (1999); United States Food and Drug Administration (1995–2023); University of Hawaii System (1986–1992); University of British Columbia (1996); University of Illinois Urbana-Champaign (2005–2011); University of Florida (1982–1985); United States Public Health Service (2000); National Institute of Environmental Health Sciences (2000); Orszagos Kornyezetegeszsegugyi Intezet (2005); National Cancer Institute (1998–2005); National Center for Epidemiology (2005); Instituto Superior Técnico (1998–2010); Centro de Química Estrutural (1998–2010); Universidade Técnica de Lisboa (2010); University of Missouri (2007); University of California, Davis (1979–1982); The University of Texas Southwestern Medical Center (1997)
76 h-index
339 pubs
19,778 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Daniel R. Doerge's research focuses on the toxicological effects and metabolic pathways of various compounds, with a particular emphasis on their impact in animal models, including rats and mice. His work has investigated the toxicokinetics of polyfluorinated compounds in pregnant and nonpregnant rats, examining how the body processes these substances following oral exposure. Additionally, Doerge has studied the effects of isoflavones, such as genistein and isoliquiritigenin, on biological processes. His research on genistein has explored its influence on mammary tumor response to tamoxifen in rats, while isoliquiritigenin has been examined for its role in decreasing bone resorption and osteoclast differentiation.
Doerge's extensive publication record, with over 339 publications and a citation count exceeding 19,000, indicates a significant contribution to the field of toxicology and pharmacology. He is recognized as a highly cited researcher. His collaborations include researchers from the National Center for Toxicological Research, such as Volodymyr Tryndyak, Frederick A. Beland, Michelle M. Vanlandingham, and Mona I. Churchwell, with whom he has co-authored publications. Doerge maintains an active laboratory website to share his research findings.
Metrics
- h-index: 76
- Publications: 339
- Citations: 19,778
Selected Publications
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
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Isoliquiritigenin Decreases Bone Resorption and Osteoclast Differentiation (2022)
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Characterizing biopersistence potential of the metabolite 5:3 fluorotelomer carboxylic acid after repeated oral exposure to the 6:2 fluorotelomer alcohol (2020)
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A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results (2019)
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Advancing human health risk assessment (2019)
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Metabolism and disposition of arsenic species from controlled dosing with dimethylarsinic acid (DMAV) in adult female CD-1 mice. V. Toxicokinetic studies following oral and intravenous administration (2019)
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Metabolism and disposition of arsenic species from controlled dosing with sodium arsenite in adult female CD-1 mice. III. Toxicokinetic studies following oral and intravenous administration (2018)
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Exposure to Arsenite in CD-1 Mice during Juvenile and Adult Stages: Effects on Intestinal Microbiota and Gut-Associated Immune Status (2018)
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Metabolism and pharmacokinetics of zearalenone following oral and intravenous administration in juvenile female pigs (2017)
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Lifetime Genistein Intake Increases the Response of Mammary Tumors to Tamoxifen in Rats (2017)
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Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study (2016)
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Irreversible down-regulation of miR-375 in the livers of Fischer 344 rats after chronic furan exposure (2016)
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Furan-induced transcriptomic and gene-specific DNA methylation changes in the livers of Fischer 344 rats in a 2-year carcinogenicity study (2016)
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Urine and serum biomonitoring of exposure to environmental estrogens II: Soy isoflavones and zearalenone in pregnant women (2016)
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Urine and serum biomonitoring of exposure to environmental estrogens I: Bisphenol A in pregnant women (2016)
Collaboration Network
Top Collaborators
Mona I. Churchwell
National Center for Toxicological Research
58 shared publications
In database
- Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
- Pharmacokinetics of bisphenol A in humans following a single oral administration
- Identification of the Colored Guaiacol Oxidation Product Produced by Peroxidases
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
Showing 5 of 58 shared publications
Nathan C. Twaddle
National Center for Toxicological Research
38 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Pharmacokinetics of bisphenol A in humans following a single oral administration
- Potential Neurotoxicity of Ketamine in the Developing Rat Brain
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Isoflavones in urine, saliva, and blood of infants: data from a pilot study on the estrogenic activity of soy formula
Showing 5 of 38 shared publications
Frederick A. Beland
National Center for Toxicological Research
25 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Toxicity and metabolism of malachite green and leucomalachite green during short-term feeding to Fischer 344 rats and B6C3F1 mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Effect of ethanol on the tumorigenicity of urethane (ethyl carbamate) in B6C3F1 mice
- Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure
Showing 5 of 25 shared publications
William G. Helferich
University of Illinois Urbana-Champaign (US)
21 shared publications
- Equol, a natural estrogenic metabolite from soy isoflavones
- Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
- Physiological Concentrations of Dietary Genistein Dose-Dependently Stimulate Growth of Estrogen-Dependent Human Breast Cancer (MCF-7) Tumors Implanted in Athymic Nude Mice
- The Soy Isoflavone Genistein Decreases Adipose Deposition in Mice
- Effects of dietary daidzein and its metabolite, equol, at physiological concentrations on the growth of estrogen-dependent human breast cancer (MCF-7) tumors implanted in ovariectomized athymic mice
Showing 5 of 21 shared publications
Jeffrey W. Fisher
National Center for Toxicological Research (US)
16 shared publications
- Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
- Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
- Pharmacokinetics of bisphenol A in neonatal and adult rhesus monkeys
- Are typical human serum BPA concentrations measurable and sufficient to be estrogenic in the general population?
- Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
Showing 5 of 16 shared publications
Michelle M. Vanlandingham
National Center for Toxicological Research
14 shared publications
In database
- Pharmacokinetics of bisphenol A in neonatal and adult Sprague-Dawley rats
- Distribution of bisphenol A into tissues of adult, neonatal, and fetal Sprague–Dawley rats
- Pharmacokinetic modeling: Prediction and evaluation of route dependent dosimetry of bisphenol A in monkeys with extrapolation to humans
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
- Pharmacokinetics of Bisphenol A in neonatal and adult CD-1 mice: Inter-species comparisons with Sprague-Dawley rats and rhesus monkeys
Showing 5 of 14 shared publications
M. Matilde Marques
University of Lisbon (PT)
13 shared publications
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- Metabolism of Biochanin A and Formononetin by Human Liver Microsomes in Vitro
- Carcinogenicity of acrylamide in B6C3F1 mice and F344/N rats from a 2-year drinking water exposure
- Formation of N-(Carboxymethyl)fumonisin B1, Following the Reaction of Fumonisin B1 with Reducing Sugars
- Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts
Showing 5 of 13 shared publications
Gonçalo Gamboa da Costa
National Center for Toxicological Research
11 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Cytogenetic Damage Induced by Acrylamide and Glycidamide in Mammalian Cells: Correlation with Specific Glycidamide-DNA Adducts
- Inhibition of Extrahepatic Human Cytochromes P450 1A1 and 1B1 by Metabolism of Isoflavones Found in Trifolium pratense (Red Clover)
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
Showing 5 of 11 shared publications
L. Patrice McDaniel
11 shared publications
- DNA adducts derived from administration of acrylamide and glycidamide to mice and rats
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- Toxicokinetics of acrylamide and glycidamide in Fischer 344 rats
- The Genotoxicity of Acrylamide and Glycidamide in Big Blue Rats
- Determination of acrylamide and glycidamide serum toxicokinetics in B6C3F1 mice using LC–ES/MS/MS
Showing 5 of 11 shared publications
Peter P. Fu
National Center for Toxicological Research (US)
11 shared publications
- Riddelliine N-oxide is a phytochemical and mammalian metabolite with genotoxic activity that is comparable to the parent pyrrolizidine alkaloid riddelliine
- Metabolic Activation of the Tumorigenic Pyrrolizidine Alkaloid, Riddelliine, Leading to DNA Adduct Formation in Vivo
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- Pyrrolizidine Alkaloid-Derived DNA Adducts as a Common Biological Biomarker of Pyrrolizidine Alkaloid-Induced Tumorigenicity
- GENOTOXIC PYRROLIZIDINE ALKALOIDS AND PYRROLIZIDINE ALKALOIDN-OXIDES—MECHANISMS LEADING TO DNA ADDUCT FORMATION AND TUMORIGENICITY
Showing 5 of 11 shared publications
K. Barry Delclos
National Center for Toxicological Research
9 shared publications
In database
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats
- Comparison of Life-Stage-Dependent Internal Dosimetry for Bisphenol A, Ethinyl Estradiol, a Reference Estrogen, and Endogenous Estradiol to Test an Estrogenic Mode of Action in Sprague Dawley Rats
- Lactational transfer of bisphenol A in Sprague–Dawley rats
- A two-year toxicology study of bisphenol A (BPA) in Sprague-Dawley rats: CLARITY-BPA core study results
Showing 5 of 9 shared publications
Hebron C. Chang
National Center for Toxicological Research (US)
7 shared publications
- Mass Spectrometric Determination of Genistein Tissue Distribution in Diet-Exposed Sprague-Dawley Rats
- Anti-Thyroid Isoflavones from Soybean
- Analysis of Soy Isoflavone Conjugation In Vitro and in Human Blood Using Liquid Chromatography-Mass Spectrometry
- Dietary Genistein Inactivates Rat Thyroid Peroxidase in Vivo without an Apparent Hypothyroid Effect
- Placental transfer of the soy isoflavone genistein following dietary and gavage administration to Sprague Dawley rats
Showing 5 of 7 shared publications
Linda S. Von Tungeln
National Center for Toxicological Research
7 shared publications
In database
- DNA Adduct Formation from Acrylamide via Conversion To Glycidamide in Adult and Neonatal Mice
- High-Performance Liquid Chromatography Electrospray Ionization Tandem Mass Spectrometry for the Detection and Quantitation of Benzo[a]pyrene−DNA Adducts
- Pyrrolizidine Alkaloid-Derived DNA Adducts as a Common Biological Biomarker of Pyrrolizidine Alkaloid-Induced Tumorigenicity
- Tumorigenicity of acrylamide and its metabolite glycidamide in the neonatal mouse bioassay
- Low dose assessment of the carcinogenicity of furan in male F344/N Nctr rats in a 2-year gavage study
Showing 5 of 7 shared publications
Mugimane G. Manjanatha
National Center for Toxicological Research
7 shared publications
In database
- Genotoxicity of acrylamide and its metabolite glycidamide administered in drinking water to male and female Big Blue mice
- In vivo genotoxicity of furan in F344 rats at cancer bioassay doses
- Mutagenicity of Acrylamide and Glycidamide in the Testes of Big Blue Mice
- Acrylamide‐induced carcinogenicity in mouse lung involves mutagenicity: cII gene mutations in the lung of big blue mice exposed to acrylamide and glycidamide for up to 4 weeks
- Flow cytometric detection of Pig‐A mutant red blood cells using an erythroid‐specific antibody: Application of the method for evaluating the in vivo genotoxicity of methylphenidate in adolescent rats
Showing 5 of 7 shared publications
Merle G. Paule
United States Food and Drug Administration
7 shared publications
In database
- Ketamine-Induced Neuronal Cell Death in the Perinatal Rhesus Monkey
- Potential Neurotoxicity of Ketamine in the Developing Rat Brain
- Analysis of methylphenidate and its metabolite ritalinic acid in monkey plasma by liquid chromatography/electrospray ionization mass spectrometry
- The effects of chronic methylphenidate administration on operant test battery performance in juvenile rhesus monkeys
- Development of a Physiologically Based Model to Describe the Pharmacokinetics of Methylphenidate in Juvenile and Adult Humans and Nonhuman Primates
Showing 5 of 7 shared publications
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