David N. Church
Assistant Professor
faculty
Research Areas
Biography and Research Information
OverviewAI-generated summary
David N. Church's research focuses on the application of computational methods and molecular insights to understand and improve cancer diagnosis and treatment. He has published work examining the genomic landscape of colorectal cancers and the development of clinical decision support systems that integrate deep learning with pathological markers to optimize adjuvant chemotherapy. His investigations also extend to endometrial cancer, where he has studied the clinical and molecular correlates of p53 immunohistochemistry and the prognostic significance of tertiary lymphoid structures. Furthermore, his work addresses the broader challenges and promises of adoptive T-cell therapies for solid tumors.
With a strong publication record, including a significant number of peer-reviewed articles, Church holds an h-index of 45 and has accumulated over 9,000 citations. His recent publications span diverse areas within oncology, including the genomic underpinnings of colorectal cancers, the role of specific mutations in endometrial cancer, and the potential of advanced computational models for biomarker prediction from histological data. He actively leads a research group and collaborates with researchers at the University of Arkansas for Medical Sciences and the University of Arkansas at Fayetteville, fostering a network of shared scientific inquiry.
His work contributes to the understanding of cancer biology and the development of data-driven approaches in clinical oncology. This includes exploring signatures of mutagenesis and evaluating treatment effects in patient populations with specific genetic profiles, such as those with POLE mutations in endometrial cancer.
Metrics
- h-index: 45
- Publications: 242
- Citations: 9,411
Selected Publications
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From Anecdote to Evidence: Dispelling Myths in Bodybuilding and Physique Sports (2026)
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Guidelines for nutrition in adults with head and neck cancer: The American Society for Parenteral and Enteral Nutrition (2026)
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Elevated miR-194-5p Expression during Short-Term Energy Deficit Attenuates Postexercise Muscle Protein Synthesis by Inhibiting Anabolic Signaling (2026)
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Effects of acute essential amino acid intake on post-prandial raw bioimpedance and fluid shifts between healthy young and older adults: An exploratory pilot study (2025)
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The effect of bed rest, unilateral limb immobilization and head‐down tilt on muscle protein synthesis: A systematic review and meta‐analysis (2025)
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Exploring the multifactorial causes and therapeutic strategies for anabolic resistance in sarcopenia: A systems modeling study (2025)
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The Effects of Essential Amino Acid Supplementation on Hippocampal Neurotrophin, Dopaminergic and Serotonergic Changes in an Overtraining Mouse Model (2025)
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Antiaging agents: pharmacological therapy targeted at preserving skeletal muscle size and function in aging adults (2025)
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Understanding Dietary Protein Quality: Digestible Indispensable Amino Acid Scores and Beyond (2025)
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Effects of exercise with or without a hypocaloric diet on intermuscular and intramuscular fat: a systematic review (2025)
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Muscle Protein Synthesis Response to Whole-Foods and Free-Form Essential Amino Acids: An Exploratory Analysis (2025)
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The effect of nandrolone decanoate administration on fatigue during a volume‐overload stress in male mice (2025)
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The Effect of Nicotinamide Mononucleotide and Riboside on Skeletal Muscle Mass and Function: A Systematic Review and Meta‐Analysis (2025)
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Proximate analysis and concordance with nutritional labeling of most sold protein bars in Santiago, Chile (2025)
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Crossover Trial of Exogenous Ketones on Cardiometabolic Endpoints in Heart Failure With Preserved Ejection Fraction (2025)
Grants & Funding
Collaboration Network
Top Collaborators
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- Evaluation of treatment effects in patients with endometrial cancer and <i>POLE</i> mutations: An individual patient data meta‐analysis
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
Showing 5 of 15 shared publications
- A clinical decision support system optimising adjuvant chemotherapy for colorectal cancers by integrating deep learning and pathological staging markers: a development and validation study
- CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance
Showing 5 of 14 shared publications
- A clinical decision support system optimising adjuvant chemotherapy for colorectal cancers by integrating deep learning and pathological staging markers: a development and validation study
- CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Non-Canonical Activin A Signaling Stimulates Context-Dependent and Cellular-Specific Outcomes in CRC to Promote Tumor Cell Migration and Immune Tolerance
- Automated assessment of CD8+ T-lymphocytes and stroma fractions complement conventional staging of colorectal cancer
Showing 5 of 12 shared publications
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
- Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer
Showing 5 of 9 shared publications
- JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
- CXD101 and nivolumab in patients with metastatic microsatellite-stable colorectal cancer (CAROSELL): a multicentre, open-label, single-arm, phase II trial
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer
Showing 5 of 9 shared publications
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Functional analysis reveals driver cooperativity and novel mechanisms in endometrial carcinogenesis
- The clinical relevance of tumor RAS/TP53 dual mutation in early and metastatic colorectal cancer (CRC).
- Accounting for intensity variation in image analysis of large‐scale multiplexed clinical trial datasets
Showing 5 of 8 shared publications
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- Evaluation of treatment effects in patients with endometrial cancer and <i>POLE</i> mutations: An individual patient data meta‐analysis
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
Showing 5 of 8 shared publications
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
Showing 5 of 8 shared publications
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
Showing 5 of 8 shared publications
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
- Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study
- 595 Implementation of collaborative translational research (TransPORTEC) findings in an international endometrial cancer clinical trials program (RAINBO)
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study
Showing 5 of 8 shared publications
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer
- Standardizing data collection in adjuvant colon cancer trials: A consensus project from the IDEA and ACCENT international consortia and national experts
- Clinical performance of Immunoscore in stage III colorectal cancer patients in the SCOT and IDEA-HORG cohorts.
Showing 5 of 8 shared publications
- JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer
- Clinical performance of Immunoscore in stage III colorectal cancer patients in the SCOT and IDEA-HORG cohorts.
Showing 5 of 8 shared publications
- JAK/STAT3 represents a therapeutic target for colorectal cancer patients with stromal-rich tumors
- Multiplex analysis of intratumoural immune infiltrate and prognosis in patients with stage II–III colorectal cancer from the SCOT and QUASAR 2 trials: a retrospective analysis
- Prognostic and Predictive Value of Immunoscore in Stage III Colorectal Cancer: Pooled Analysis of Cases From the SCOT and IDEA-HORG Studies
- Single-cell AI-based detection and prognostic and predictive value of DNA mismatch repair deficiency in colorectal cancer
- Clinical performance of Immunoscore in stage III colorectal cancer patients in the SCOT and IDEA-HORG cohorts.
Showing 5 of 8 shared publications
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
- 595 Implementation of collaborative translational research (TransPORTEC) findings in an international endometrial cancer clinical trials program (RAINBO)
Showing 5 of 7 shared publications
- p53 immunohistochemistry in endometrial cancer: clinical and molecular correlates in the PORTEC-3 trial
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients
- Prediction of recurrence risk in endometrial cancer with multimodal deep learning
- Neoadjuvant immune checkpoint blockade in women with mismatch repair deficient endometrial cancer: a phase I study
- Tertiary lymphoid structures critical for prognosis in endometrial cancer patients - a TransPORTEC study
Showing 5 of 7 shared publications
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