Dominique J. Laster
Researcher
University of Arkansas for Medical Sciences
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Biography and Research Information
OverviewAI-generated summary
Dominique J. Laster's research focuses on the molecular mechanisms underlying bone health and aging, with a particular emphasis on autophagy, a cellular process crucial for maintaining cellular homeostasis. Laster has investigated the role of chaperone-mediated autophagy (CMA) in regulating bone mass, finding that its loss is associated with lower vertebral cancellous bone density. Further studies have examined the impact of CMA loss on age-related bone loss in male mice, indicating no significant alteration in this specific context. Laster has also explored advancements in genetic engineering tools, comparing the cell type-specificity of CRISPR interference with the established Cre-loxP system. Collaborations with researchers at the University of Arkansas for Medical Sciences, including Melda Onal, Julie Crawford, Nisreen Akel, and Stuart B. Berryhill, have contributed to a shared publication record. Laster's scholarly output includes 3 publications with a total of 21 citations and an h-index of 3.
Metrics
- h-index: 3
- Publications: 3
- Citations: 21
Selected Publications
- Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice (2024) DOI
- CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system (2023) DOI
- Loss of chaperone-mediated autophagy is associated with low vertebral cancellous bone mass (2022) DOI
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