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Biography and Research Information
OverviewAI-generated summary
A. Gordon James's research investigates the molecular mechanisms underlying bone aging and strength, with a particular focus on the role of autophagy.
His work has explored the impact of the master autophagy regulator Tfeb in osteoblast lineage cells, demonstrating that its activation can increase bone mass and strength. James has also examined the effects of mitochondrial oxidative stress and decreased autophagy on bone mechanoresponsiveness in the context of aging, finding that these factors alone do not fully replicate the age-related decline in bone properties. His research further includes studies on the contribution of chaperone-mediated autophagy to age-related bone loss in male mice.
Additionally, James has contributed to research on axillary odor variation and the application of CRISPR technology for enhanced cell type specificity in genetic studies. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Melda Onal and Maria Almeida.
Metrics
- h-index: 11
- Publications: 21
- Citations: 666
Selected Publications
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The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)
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Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength (2025)
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Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025)
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CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength (2024)
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Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice (2024)
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CRISPR interference provides increased cell type-specificity compared to the Cre-loxP system (2023)
Collaboration Network
Top Collaborators
Melda Onal
University of Arkansas for Medical Sciences
5 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Maria Almeida
University of Arkansas for Medical Sciences
4 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
James A. Hendrixson
University of Arkansas for Medical Sciences
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Julie Crawford
Institute for Musculoskeletal Health
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Loss of chaperone‐mediated autophagy does not alter age‐related bone loss in male mice
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Ilham Kadhim
University of Arkansas for Medical Sciences
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Jinhu Xiong
University of Arkansas for Medical Sciences
3 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Adriana Lelis Carvalho
University of Arkansas for Medical Sciences
2 shared publications
In database
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Jacob Laster
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Jeff Thostenson
University of Arkansas for Medical Sciences (US)
2 shared publications
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Amy Y. Sato
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- CRISPR activation of <i>Tfeb</i> , a master regulator of autophagy and lysosomal biogenesis, in osteoblast lineage cells increases bone mass and strength
Ana I. Coelho
University of Arkansas for Medical Sciences
2 shared publications
In database
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Aaron Warren
University of Arkansas for Medical Sciences
2 shared publications
In database
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Landon Gatrell
University of Arkansas for Medical Sciences (US)
2 shared publications
- Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Intawat Nookaew
University of Arkansas for Medical Sciences
2 shared publications
In database
- Elevation of master autophagy regulator Tfeb in osteoblast lineage cells increases bone mass and strength
- The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone
Francesca Di Cicco
Utrecht University (NL)
1 shared publication
- Intrinsic and extrinsic factors affecting axillary odor variation. A comprehensive review
Similar Researchers
Based on overlapping research topics
Julie Crawford
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
CRISPR and Genetic Engineering
Autophagy
Jacob Laster
University of Arkansas for Medical Sciences
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CRISPR and Genetic Engineering
Dominique J. Laster
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Autophagy
Jacob Kordsmeier
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Mitochondrial Function and Pathology
Ankita Chalke
University of Arkansas for Medical Sciences
Bone Metabolism and Diseases
Mitochondrial Function and Pathology
Stavros C. Manolagas
University of Arkansas for Medical Sciences
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