Xilin Li Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Scientist

National Center for Toxicological Research

faculty

3 h-index 15 pubs 64 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Cannabis and Cannabinoid Research Phytochemicals and Antioxidant Activities Drug-Induced Hepatotoxicity and Protection Metabolomics and Mass Spectrometry Studies Molecular Biology Techniques and Applications

Links

ORCID Research Group

Is this your profile? Verify and claim your profile

OverviewAI-generated summary

Xilin Li's research focuses on the genotoxicity and metabolism of various chemical compounds, with a particular emphasis on drug impurities and naturally occurring substances. Li has investigated the genotoxic potential of nitrosamine impurities using human TK6 cells engineered to express cytochrome P450 enzymes. Further studies have examined the mutagenicity and genotoxicity of nitrosamine drug substance-related impurities in both 2D and 3D HepaRG cell models. In addition to drug impurities, Li's work includes evaluating the metabolism and liver toxicity of cannabidiol, as well as comparing its transcriptomic effects in human and mouse Sertoli cells. Other research areas include the potential anticancer effects and toxicity of flavones like luteolin and apigenin, and a review of black cohosh-induced toxicity. Li has authored 15 publications with 64 citations and an h-index of 3, and collaborates with several researchers at the National Center for Toxicological Research, including Nan Mei, Yuan Le, Robert H. Heflich, and Xiaobo He.

Metrics

  • h-index: 3
  • Publications: 15
  • Citations: 64

Selected Publications

  • Genotoxicity evaluation of ten nitrosamine drug substance-related impurities using 2D and 3D HepaRG cell models (2025) DOI
  • Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025) DOI
  • Review of black cohosh-induced toxicity and adverse clinical effects (2025) DOI
  • Development of a TK6-derived cell line expressing four human cytochrome P450s for genotoxicity testing (2025) DOI
  • Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025) DOI
  • Mutagenicity and genotoxicity evaluation of 15 nitrosamine drug substance-related impurities in human TK6 cells (2024) DOI
  • Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024) DOI
  • Metabolism and liver toxicity of cannabidiol (2024) DOI
  • Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024) DOI
  • Genotoxicity evaluation of nitrosamine impurities using human TK6 cells transduced with cytochrome P450s (2022) DOI

Collaborators

Researchers in the database who share publications

Nan Mei National Center for Toxicological Research 7 shared publications Yuan Le National Center for Toxicological Research 4 shared publications Robert H. Heflich National Center for Toxicological Research 4 shared publications Xiaobo He National Center for Toxicological Research 3 shared publications Qiangen Wu National Center for Toxicological Research 2 shared publications Mugimane G. Manjanatha National Center for Toxicological Research 2 shared publications Matthew Bryant National Center for Toxicological Research 1 shared publication Barbara L. Parsons National Center for Toxicological Research 1 shared publication

Similar Researchers

Based on overlapping research topics

Peter Fu National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Phytochemicals and Antioxidant Activities
Good match 4 shared topics
Qiangen Wu National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Cannabis and Cannabinoid Research
Good match 5 shared topics
Yuet-Kin Leung University of Arkansas for Medical Sciences
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection
Good match 4 shared topics
Dayton M. Petibone National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Cannabis and Cannabinoid Research
Good match 4 shared topics
Rebecca Wynne National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection
Good match 4 shared topics
Jian Yan National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Drug-Induced Hepatotoxicity and Protection
Good match 3 shared topics