Haven Griffin
Researcher
Also affiliated: University of Arkansas Medical Center (2019); Biotechnology and Biological Sciences Research Council (1981); Arkansas Department of Agriculture (2019)
Unknown Researcher
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Haven Griffin's research investigates the molecular mechanisms underlying neuronal function, with a particular focus on the hypothalamus. Recent work has explored the effects of liraglutide, a medication used to treat type 2 diabetes and obesity, on endoplasmic reticulum stress in hypothalamic neurons. This research also examined liraglutide's impact on mitochondrial homeostasis in palmitate-treated neurons. Another area of investigation has been the localization of the melanocortin 4 receptor (MC4R) within these neurons, specifically at excitatory postsynaptic and peri-postsynaptic sites in primary cell cultures.
Griffin is also involved in a federal grant as a Co-Principal Investigator, funded by the NIH, totaling $588,106. This project focuses on the Protein C pathway and its role in mitigating radiation-induced endothelial and vascular dysfunction. Collaborations include work with Giulia Baldini and Steven W. Barger at the University of Arkansas for Medical Sciences, and Kevin D. Phelan at the University of Arkansas at Fayetteville.
Metrics
- h-index: 3
- Publications: 6
- Citations: 56
Selected Publications
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MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture (2024)
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Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis (2022)
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Selective Survival of Sim1/MC4R Neurons in Diet-Induced Obesity (2020)
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Delivery of phosphatidylethanolamine blunts stress in hepatoma cells exposed to elevated palmitate by targeting the endoplasmic reticulum (2020)
Federal Grants 1 $588,106 total
The Protein C Pathway in Mitigation of Radiation-Induced Endothelial and Vascular Dysfunction
Collaboration Network
Top Collaborators
- Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis
- MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture
- Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis
- MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture
- Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis
- Liraglutide Counteracts Endoplasmic Reticulum Stress in Palmitate-Treated Hypothalamic Neurons without Restoring Mitochondrial Homeostasis
- MC4R Localizes at Excitatory Postsynaptic and Peri-Postsynaptic Sites of Hypothalamic Neurons in Primary Culture
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