Biography and Research Information
OverviewAI-generated summary
Jaime A. Miranda is a biologist at the National Center for Toxicological Research. His research focuses on the assessment of chemical mutagens and their effects on genetic material. Miranda has investigated the mutagenic potential of compounds such as Molnupiravir and N-nitrosodimethylamine using advanced sequencing technologies like PacBio and HiFi sequencing. His work utilizes both bacterial and mammalian cell systems, including HepaRG cells and mouse lymphoma L5178Y cells, as well as whole organisms like *Caenorhabditis elegans*.
Miranda's publications explore the application of high-throughput and long-read sequencing for detecting ultra-low-frequency mutations across the genome. This includes assessing *in vivo* chemical mutagenesis and identifying off-target mutations in genome-edited cell populations. He also studies the accumulation of somatic cell mutations in organotypic airway cultures following exposure to mutagens like ethyl methanesulfonate. Miranda has a h-index of 6 and has published 14 papers with 104 citations. Key collaborators include Javier R. Revollo, Page B. McKinzie, Vasily N. Dobrovolsky, and Robert H. Heflich, all from the National Center for Toxicological Research.
Metrics
- h-index: 6
- Publications: 14
- Citations: 115
Selected Publications
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Mutagenicity of <i>N</i> -nitroso-fluoxetine and <i>N</i> -nitroso-varenicline in human HepaRG cell models (2026)
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Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen (2025)
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Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing (2025)
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Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection (2024)
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Assessment of in vivo chemical mutagenesis by long-read sequencing (2024)
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Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations (2024)
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Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp (2024)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023)
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Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp (2023)
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Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022)
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Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022)
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<scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens (2021)
Collaboration Network
Top Collaborators
Javier R. Revollo
National Center for Toxicological Research
12 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Assessment of in vivo chemical mutagenesis by long-read sequencing
Showing 5 of 12 shared publications
Vasily N. Dobrovolsky
National Center for Toxicological Research
4 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- <scp>PacBio</scp> sequencing detects genome‐wide ultra‐low‐frequency substitution mutations resulting from exposure to chemical mutagens
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Page B. McKinzie
National Center for Toxicological Research
4 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Kidon Sung
National Center for Toxicological Research
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Saeed Khan
National Center for Toxicological Research
3 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Mohamed S. Nawaz
United States Food and Drug Administration (US)
3 shared publications
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Robert H. Heflich
United States Food and Drug Administration
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
Xiaoqing Guo
National Center for Toxicological Research
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing
- Mutation accumulation following extended exposure of human HepaRG cells to a genotoxic carcinogen
Khulud Alotaibi
Saudi Arabian Monetary Authority
2 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
Ashraf A. Khan
United States Food and Drug Administration
2 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Draft Genome Sequences of 14 Fluoroquinolone-Resistant Escherichia coli Isolates from Imported Shrimp
Ji‐Eun Seo
National Center for Toxicological Research
2 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Background Mutation Frequencies in <scp>TK6</scp> and <scp>L5178Y</scp> Cells: Implications for Error‐Corrected Sequencing
Yuan Le
National Center for Toxicological Research
2 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Nan Mei
United States Food and Drug Administration
2 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Timothy W. Robison
Center for Drug Evaluation and Research (US)
2 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Repeat treatment of organotypic airway cultures with ethyl methanesulfonate causes accumulation of somatic cell mutations without expansion of bronchial-carcinoma-specific cancer driver mutations
Miseon Park
National Center for Toxicological Research
2 shared publications
In database
- Whole-Genome Sequence Analysis of Antibiotic Resistance, Virulence, and Plasmid Dynamics in Multidrug-Resistant E. coli Isolates from Imported Shrimp
- Complete genome sequence of cephalosporin and tetracycline-resistant <i>Citrobacter freundii</i> CF51 isolate from a patient with urinary tract infection
Similar Researchers
Based on overlapping research topics
Page B. McKinzie
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Javier R. Revollo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Robert H. Heflich
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Vasily N. Dobrovolsky
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Meagan B. Myers
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Michelle E. Bishop
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
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