P
Page B. McKinzie Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Microbiologist
faculty
14 h-index
36 pubs
481 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Page B. McKinzie's research focuses on investigating mutagenicity and its detection using advanced sequencing technologies. Their work involves evaluating the effects of various compounds, including Molnupiravir and N-nitrosodimethylamine, on cellular and organismal genomes. McKinzie employs high-fidelity (HiFi) and error-corrected next-generation sequencing methods, such as PacBio sequencing, to detect ultralow-frequency substitution mutations across diverse biological systems, including bacterial and mammalian cells, mouse lymphoma L5178Y cells, and Caenorhabditis elegans worms.
Further research includes the genome-wide detection of off-target mutations in genome-edited cell populations and the characterization of mutagenicity in vivo. McKinzie also studies mutational signatures in specific cell types, such as T-lymphocytes in rats treated with known mutagens, and investigates erythrocyte PIG-A mutant frequencies in cancer patients undergoing specific treatments. Their publications demonstrate a consistent application of molecular biology techniques to assess genetic damage and mutation frequencies in various contexts.
Metrics
- h-index: 14
- Publications: 36
- Citations: 481
Selected Publications
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Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin (2024)
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Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023)
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Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023)
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A Brief Practical Guide to PCR (2023)
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Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022)
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Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022)
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Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine (2021)
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<i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021)
Collaboration Network
Top Collaborators
Vasily N. Dobrovolsky
National Center for Toxicological Research
9 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
Showing 5 of 9 shared publications
Javier R. Revollo
United States Food and Drug Administration
8 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
Showing 5 of 8 shared publications
Jaime A. Miranda
National Center for Toxicological Research
4 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Mason G. Pearce
National Center for Toxicological Research
3 shared publications
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Robert H. Heflich
National Center for Toxicological Research
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
Timothy W. Robison
Center for Drug Evaluation and Research (US)
3 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
J. Jaime Miranda
National Center for Toxicological Research (US)
2 shared publications
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Meagan B. Myers
National Center for Toxicological Research
2 shared publications
In database
- A Brief Practical Guide to PCR
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Azra Dad
National Center for Toxicological Research
1 shared publication
In database
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
Alexander W. Alund
National Center for Toxicological Research
1 shared publication
In database
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
Jian Yan
United States Food and Drug Administration (US)
1 shared publication
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
Stephen D. Dertinger
Litron Laboratories (United States) (US)
1 shared publication
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Jeffrey C. Bemis
Litron Laboratories (United States) (US)
1 shared publication
- Detecting N-ethyl-N-nitrosourea-induced mutation in the tissues of mice using whole-genome HiFi Sequencing
Kristina Fenner
United States Food and Drug Administration (US)
1 shared publication
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Tomonari Matsuda
Kyoto University (JP)
1 shared publication
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
Similar Researchers
Based on overlapping research topics
Jaime A. Miranda
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Robert H. Heflich
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Meagan B. Myers
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Javier R. Revollo
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Vasily N. Dobrovolsky
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
Pharmacological Effects and Toxicity Studies
Karen L. McKim
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
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