Page B. McKinzie Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Research Microbiologist

National Center for Toxicological Research

faculty

14 h-index 37 pubs 478 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Molecular Biology Techniques and Applications Genomics and Phylogenetic Studies Cancer-related molecular mechanisms research Microbial infections and disease research Bioinformatics and Genomic Networks

Links

ORCID Lab Website

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OverviewAI-generated summary

Page B. McKinzie is a Research Microbiologist at the National Center for Toxicological Research. Their work focuses on evaluating the mutagenic effects of various compounds using advanced sequencing technologies. Recent publications investigate the mutagenicity of Molnupiravir and N-nitrosodimethylamine in bacterial and mammalian cell cultures, employing HiFi and error-corrected next-generation sequencing. McKinzie has also explored genome-wide detection of ultralow-frequency substitution mutations in mouse lymphoma cells and Caenorhabditis elegans using PacBio sequencing. Further research includes unbiased whole-genome detection of off-target mutations in genome-edited cell populations and the characterization of mutagenicity in vivo. The researcher has also examined mutational signatures in T-lymphocytes of rats treated with specific agents and PIG-A mutant frequencies in cancer patients receiving cisplatin. McKinzie's scholarship metrics include an h-index of 14, with 37 total publications and 478 total citations. Key collaborators include Vasily N. Dobrovolsky, Javier R. Revollo, Jaime A. Miranda, and Robert H. Heflich, all from the National Center for Toxicological Research.

Metrics

h-index: 14
Publications: 37
Citations: 478

Selected Publications

Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026) DOI
Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024) DOI
Erythrocyte PIG‐A mutant frequencies in cancer patients receiving cisplatin (2024) DOI
Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023) DOI
Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023) DOI
A Brief Practical Guide to PCR (2023) DOI
Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022) DOI
Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and Caenorhabditis elegans worms by <scp>PacBio</scp> sequencing (2022) DOI
Mutational signatures in T‐lymphocytes of rats treated with N<scp>‐propyl‐</scp>N‐nitrosourea and procarbazine (2021) DOI
Pig‐a gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021) DOI