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Confirmed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-08-08
P
Page B. McKinzie
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Research Microbiologist
Also affiliated: United States Food and Drug Administration (2004–2024); Central Arkansas Veterans Healthcare System (2007); Food and Drug Administration (2004)
Faculty Researcher
14 h-index
36 pubs
484 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Page B. McKinzie, a Research Microbiologist at the National Center for Toxicological Research, investigates the mutagenic effects of various compounds using advanced sequencing technologies. Recent studies have focused on evaluating the mutagenicity of Molnupiravir and N4-hydroxycytidine in bacterial and mammalian cells, employing HiFi sequencing. McKinzie has also examined the mutagenicity of N-nitrosodimethylamine in HepaRG cell cultures using error-corrected next-generation sequencing and has utilized PacBio sequencing for genome-wide detection of ultralow-frequency substitution mutations in mouse lymphoma cells and *Caenorhabditis elegans*. Other work includes the unbiased whole-genome detection of off-target mutations in genome-edited cell populations and the characterization of mutagenicity in vivo. McKinzie has also studied mutational signatures in rat lymphocytes and erythrocyte PIG-A mutant frequencies in cancer patients. McKinzie has a publication record of 36 papers, with an h-index of 14 and 483 citations. Key collaborators include Vasily N. Dobrovolsky, Javier R. Revollo, and Jaime A. Miranda, all from the National Center for Toxicological Research.
Metrics
- h-index: 14
- Publications: 36
- Citations: 484
Selected Publications
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Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans (2026)
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Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing (2024)
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Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin (2024)
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Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo (2023)
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Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing (2023)
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A Brief Practical Guide to PCR (2023)
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Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing (2022)
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Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing (2022)
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Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine (2021)
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<i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats (2021)
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A Streamlined and High-Throughput Error-Corrected Next-Generation Sequencing Method for Low Variant Allele Frequency Quantitation (2019)
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Reduced vancomycin susceptibility and increased macrophage survival in Staphylococcus aureus strains sequentially isolated from a bacteraemic patient during a short course of antibiotic therapy (2019)
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Evaluation of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) mutagenicity using in vitro and in vivo Pig-a assays (2018)
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Lifespan <i>Kras</i> mutation levels in lung and liver of B6C3F<sub>1</sub> mice (2018)
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Spectrum of Pig-a mutations in T lymphocytes of rats treated with procarbazine (2017)
Collaboration Network
Top Collaborators
Vasily N. Dobrovolsky
National Center for Toxicological Research
8 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
Showing 5 of 8 shared publications
Javier R. Revollo
United States Food and Drug Administration
7 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
Showing 5 of 7 shared publications
Jaime A. Miranda
National Center for Toxicological Research
4 shared publications
In database
- Evaluation of the mutagenic effects of Molnupiravir and <scp>N4</scp>‐hydroxycytidine in bacterial and mammalian cells by <scp>HiFi</scp> sequencing
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Mason G. Pearce
National Center for Toxicological Research
3 shared publications
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Robert H. Heflich
National Center for Toxicological Research
3 shared publications
In database
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
Timothy W. Robison
Center for Drug Evaluation and Research (US)
3 shared publications
- Evaluating the mutagenicity of N-nitrosodimethylamine in 2D and 3D HepaRG cell cultures using error-corrected next generation sequencing
- Mutational signatures in T‐lymphocytes of rats treated with <i>N</i><scp>‐propyl‐</scp><i>N</i>‐nitrosourea and procarbazine
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
Meagan B. Myers
National Center for Toxicological Research
2 shared publications
In database
- A Brief Practical Guide to PCR
- Using error-corrected sequencing for evaluating mutagenicity of molnupiravir in humans
Azra Dad
National Center for Toxicological Research
1 shared publication
In database
- <i>Pig‐a</i> gene mutations in bone marrow granulocytes of procarbazine‐treated <scp>F344</scp> rats
Alexander W. Alund
National Center for Toxicological Research
1 shared publication
In database
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
Jian Yan
United States Food and Drug Administration (US)
1 shared publication
- Genome‐wide detection of ultralow‐frequency substitution mutations in cultures of mouse lymphoma <scp>L5178Y</scp> cells and <i>Caenorhabditis elegans</i> worms by <scp>PacBio</scp> sequencing
Kristina Fenner
United States Food and Drug Administration (US)
1 shared publication
- Unbiased whole genome detection of ultrarare off‐target mutations in genome‐edited cell populations by <scp>HiFi</scp> sequencing
Tomonari Matsuda
Kyoto University (JP)
1 shared publication
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
J. Jaime Miranda
National Center for Toxicological Research (US)
1 shared publication
- Whole-genome high-fidelity sequencing: A novel approach to detecting and characterization of mutagenicity in vivo
Omar Atiq
University of Arkansas for Medical Sciences (US)
1 shared publication
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
Mackean P. Maisha
National Center for Toxicological Research
1 shared publication
In database
- Erythrocyte <i>PIG‐A</i> mutant frequencies in cancer patients receiving cisplatin
Similar Researchers
Based on overlapping research topics
Jaime A. Miranda
National Center for Toxicological Research
Carcinogens and Genotoxicity Assessment
Molecular Biology Techniques and Applications
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Vasily N. Dobrovolsky
National Center for Toxicological Research
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Javier R. Revollo
National Center for Toxicological Research
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Meagan B. Myers
National Center for Toxicological Research
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S A Montoya Guerrero
National Center for Toxicological Research
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Robert H. Heflich
National Center for Toxicological Research
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