Q
Qiang Shi Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Senior Staff Fellow
staff
34 h-index
203 pubs
10,570 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Qiang Shi's research investigates mechanisms of drug-induced liver injury and explores the role of ubiquitination in cellular processes. His work has included the co-culture of human primary hepatocytes and nonparenchymal liver cells in a liver-chip model to study drug-induced liver injury. Shi has also examined the structural and mechanistic aspects of deubiquitination by specific enzymes, such as USP16's role in H2AK119 deubiquitination.
Further research by Shi has delved into the role of ferroptosis in Alzheimer's disease and the protective effects of combined nicotinamide mononucleotide and lycopene against cognitive impairment and oxidative damage in aging models, mediated by the Keap1-Nrf2 signaling pathway. His publications also cover the creation of synthetic ubiquitinated nucleosome conjugates for studying ubiquitination processes and the development of DNAzyme-based methods for identifying low-abundance biomarkers.
Metrics
- h-index: 34
- Publications: 203
- Citations: 10,570
Selected Publications
-
Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025)
-
Single-cell RNA-sequencing and subcellular spatial transcriptomics facilitate the translation of liver microphysiological systems for regulatory application (2023)
-
Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022)
-
Metabolism of carcinogenic pyrrolizidine alkaloids and pyrrolizidine alkaloid<i>N</i>-oxides by rat primary hepatocytes generate the same characteristic DHP-DNA adducts (2021)
Collaboration Network
Top Collaborators
Yunping Qi
9 shared publications
- Narrow-band notch filter and refractive index sensor based on rectangular-semi-annular cavity coupled with MIM waveguide structure
- Dual-function tunable metasurface for polarization-insensitive electromagnetic induction transparency and dual-band absorption
- High-Q optical metasurfaces: from quasi-BIC modulation to ultra-narrowband absorption in the near-infrared spectrum
- Tunable plasmon refractive index sensor and a slow-light device optimized by an improved genetic algorithm based on a MIM waveguide
- Switchable bi-functional metasurface for absorption and broadband polarization conversion in terahertz band using vanadium dioxide and photosensitive silicon
Showing 5 of 9 shared publications
Xiangxian Wang
Lanzhou University of Technology (CN)
8 shared publications
- Narrow-band notch filter and refractive index sensor based on rectangular-semi-annular cavity coupled with MIM waveguide structure
- Dual-function tunable metasurface for polarization-insensitive electromagnetic induction transparency and dual-band absorption
- High-Q optical metasurfaces: from quasi-BIC modulation to ultra-narrowband absorption in the near-infrared spectrum
- Tunable plasmon refractive index sensor and a slow-light device optimized by an improved genetic algorithm based on a MIM waveguide
- Switchable bi-functional metasurface for absorption and broadband polarization conversion in terahertz band using vanadium dioxide and photosensitive silicon
Showing 5 of 8 shared publications
Zihao Zhou
8 shared publications
- Dual-function tunable metasurface for polarization-insensitive electromagnetic induction transparency and dual-band absorption
- High-Q optical metasurfaces: from quasi-BIC modulation to ultra-narrowband absorption in the near-infrared spectrum
- Tunable plasmon refractive index sensor and a slow-light device optimized by an improved genetic algorithm based on a MIM waveguide
- Switchable bi-functional metasurface for absorption and broadband polarization conversion in terahertz band using vanadium dioxide and photosensitive silicon
- Multiple Fano resonances inspired by bound states in all-dielectric double-opening resonant ring metasurfaces
Showing 5 of 8 shared publications
Huasong Ai
Shanghai Jiao Tong University (CN)
7 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Showing 5 of 7 shared publications
Zebin Tong
Center for Life Sciences (CN)
7 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Showing 5 of 7 shared publications
Zhiheng Deng
Tsinghua University (CN)
7 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Showing 5 of 7 shared publications
Jiabin Li
Soochow University (CN)
7 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Showing 5 of 7 shared publications
Lei Liu
Tsinghua University (CN)
7 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Showing 5 of 7 shared publications
Man Pan
Shanghai Jiao Tong University (CN)
6 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
Showing 5 of 6 shared publications
Maoshen Sun
Tsinghua University (CN)
5 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
- Synovial 1 Sarcoma X Breakpoint Protein Uses a Cryptic Groove to Selectively Recognize H2AK119Ub Nucleosomes
Wei Yi
Chongqing Bureau of Geology and Minerals Exploration (CN)
4 shared publications
- Climate variability during the late Ediacaran: Insights from episodic deposition of black shale-hosted Mn‑carbonates in South China
- Manganese carbonate stromatolites of the Ediacaran Doushantuo Formation in Chengkou, northern Yangtze Craton, China
- Stratigraphic framework and sedimentary evolution during the Cryogenian-Ediacaran transition in northeastern Sichuan Basin, South China
- Extreme organic matter enrichment in the Ediacaran Doushantuo formation: New constraints from the NE Sichuan basin, China
Yunxiang Du
Tsinghua University (CN)
4 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Synovial 1 Sarcoma X Breakpoint Protein Uses a Cryptic Groove to Selectively Recognize H2AK119Ub Nucleosomes
Ziyu Xu
Tsinghua University (CN)
4 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanistic insights into nucleosomal H2B monoubiquitylation mediated by yeast Bre1-Rad6 and its human homolog RNF20/RNF40-hRAD6A
- Synovial 1 Sarcoma X Breakpoint Protein Uses a Cryptic Groove to Selectively Recognize H2AK119Ub Nucleosomes
Lujun Liang
University of Science and Technology of China (CN)
4 shared publications
- Synthetic E2-Ub-nucleosome conjugates for studying nucleosome ubiquitination
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Mechanism of nucleosomal H2A K13/15 monoubiquitination and adjacent dual monoubiquitination by RNF168
- Synovial 1 Sarcoma X Breakpoint Protein Uses a Cryptic Groove to Selectively Recognize H2AK119Ub Nucleosomes
Guo‐Chao Chu
University of Science and Technology of China (CN)
4 shared publications
- Synovial sarcoma X breakpoint 1 protein uses a cryptic groove to selectively recognize H2AK119Ub nucleosomes
- Structural and mechanistic basis for nucleosomal H2AK119 deubiquitination by single-subunit deubiquitinase USP16
- Promotion of RNF168‐Mediated Nucleosomal H2A Ubiquitylation by Structurally Defined K63‐Polyubiquitylated Linker Histone H1
- Synovial 1 Sarcoma X Breakpoint Protein Uses a Cryptic Groove to Selectively Recognize H2AK119Ub Nucleosomes
Similar Researchers
Based on overlapping research topics
Youzhong Yuan
University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection
Ubiquitin and proteasome pathways
Diet and metabolism studies
Alexander J. Layman
University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection
Molecular Biology Techniques and Applications
Diet and metabolism studies
Igor P. Pogribny
National Center for Toxicological Research
Drug-Induced Hepatotoxicity and Protection
Epigenetics and DNA Methylation
Diet and metabolism studies
Rick Edmundson
University of Arkansas for Medical Sciences
Epigenetics and DNA Methylation
Molecular Biology Techniques and Applications
Disease Mechanisms Research
Matthew Deneke
University of Arkansas for Medical Sciences
Ubiquitin and proteasome pathways
Molecular Biology Techniques and Applications
Disease Mechanisms Research
Madison Blue
University of Arkansas for Medical Sciences
Drug-Induced Hepatotoxicity and Protection
Molecular Biology Techniques and Applications
Liver Disease Diagnosis and Treatment