Jinhu Xiong

Federal Grant PI High Impact

Associate Professor

UAMS

Last publication 2026 Last refreshed 2026-05-22

faculty

Orthopaedics Surgery, College of Medicine

jxiong@uams.edu

22 h-index 40 pubs 4,272 cited

Research Areas

Links

ORCID Lab Website UAMS TRI Profile

OverviewAI-generated summary

Jinhu Xiong, an Associate Professor in Orthopaedics Surgery at the University of Arkansas for Medical Sciences, investigates bone biology and the mechanisms of bone loss, particularly in the context of aging. His research focuses on cellular and molecular pathways that regulate bone homeostasis and strength.

Xiong's work includes studies on osteocytes and their role in mechanotransduction, the process by which cells sense and respond to mechanical forces. He has published research examining the function of the Piezo1 channel in bone, its influence on mitochondrial activity, and its potential role in mitigating age-associated bone loss. His laboratory also explores the identity and function of mesenchymal cell types involved in bone formation and remodeling, as well as the impact of autophagy regulators on bone mass and strength.

His research has been supported by federal grants, including a $324,368 award from the NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases to study the role of Piezo1 in bone homeostasis and mechanotransduction. Xiong is a highly cited researcher with an h-index of 22 based on 39 publications. He collaborates with researchers at the University of Arkansas for Medical Sciences, including Melda Onal, Charles A. O’Brien, Maria Almeida, and Ha‐Neui Kim.

Metrics

h-index: 22
Publications: 40
Citations: 4,272

Selected Publications

Dissecting primary versus secondary effects of osteogenesis imperfecta on abnormal lung development and function (2026)

DOI OpenAlex
The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)

2 citations DOI OpenAlex
Different effects of moderate tibial loading and Yoda1 on breast cancer-induced osteolysis in aged mice (2025)

1 citation DOI OpenAlex
Mitochondrial oxidative stress or decreased autophagy in osteoblast lineage cells is not sufficient to mimic the deleterious effects of aging on bone mechanoresponsiveness (2025)

4 citations DOI OpenAlex
Piezo1 expression in mature osteocytes is dispensable for the skeletal response to mechanical loading (2024)

9 citations DOI OpenAlex
Mitigating aging and doxorubicin induced bone loss in mature mice via mechanobiology based treatments (2024)

7 citations DOI OpenAlex
Refining the identity of mesenchymal cell types associated with murine periosteal and endosteal bone (2024)

23 citations DOI OpenAlex
A framework for defining mesenchymal cell types associated with murine periosteal and endosteal bone (2023)

1 citation DOI OpenAlex
Piezo1 opposes age‐associated cortical bone loss (2023)

25 citations DOI OpenAlex
Piezo1 stimulates mitochondrial function via <scp>cAMP</scp> signaling (2022)

22 citations DOI OpenAlex
Deletion of a putative promoter-proximal Tnfsf11 regulatory region in mice does not alter bone mass or Tnfsf11 expression in vivo (2021)

7 citations DOI OpenAlex
New Advances in Osteocyte Mechanotransduction (2021)

44 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 1 $324,368 total

NIH/National Institute of Arthritis and Musculoskeletal and Skin Diseases Contact PI Aug 2020 - Jun 2026

The role of Piezo1 in bone homeostasis and mechanotransduction

National Institute of Arthritis and Musculoskeletal and Skin Diseases $324,368 R01

Grants & Funding

Osteocyte Control of Bone Remodeling NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Co-Investigator
Center for Musculoskeletal Disease Research (CMDR) NIH/Nat. Inst. of General Medical Sciences Co-Investigator
The role of Piezo 1 in bone homeostasis and mechanotransduction NIH/Nat. Inst. of Arthritis & Musculoskeletal & Skin Diseases Principal Investigator