John D. Imig
◆ ARA Academy
Federal Grant PI
High Impact
Professor
faculty
COP | College of Pharmacy
72 h-index
427 pubs
16,211 cited
Research Areas
Biography and Research Information
OverviewAI-generated summary
John D. Imig's research focuses on cardiovascular and kidney disease, particularly investigating the role of epoxyeicosatrienoic acids (EETs) and their related enzymes in regulating blood pressure and mitigating organ damage. His work has explored the therapeutic potential of EET analogs in conditions such as hypertension, heart failure, and cisplatin-induced nephrotoxicity. He has investigated how manipulating epoxide hydrolase activity can influence disease progression, focusing on mechanisms involving inflammation, oxidative stress, and fibrotic pathways.
His funded research includes an NIH/NIDDK grant examining the interplay between endothelial epoxyeigenases, kidney injury, and blood pressure regulation. He also serves as PI on an NIH/NCATS grant supporting postdoctoral training at the University of Arkansas for Medical Sciences. Imig has a publication record of over 426 articles, with an h-index of 72 and more than 16,000 citations, highlighting his extensive contributions to the field. He leads a research group and collaborates with colleagues at the University of Arkansas for Medical Sciences, including Samaneh Goorani and Abdul H. Khan.
Metrics
- h-index: 72
- Publications: 427
- Citations: 16,211
Selected Publications
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Editorial: New insights on vascular and metabolic diabetic complications (2026)
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NF Erythroid 2-Related Factor 2 Peroxisome Proliferator-Activated Receptor-γ Crosstalk (2025)
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EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage (2025)
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Targeting p66Shc to restore KATP channel and renal microvascular responses in a preclinical model of diabetic nephropathy (2025)
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Prevention of hypertension-induced renal vascular dysfunction through a p66Shc-targeted mechanism (2025)
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591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice (2025)
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Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death (2025)
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Hypertension: A Continuing Public Healthcare Issue (2024)
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The Immune System in Nephrotoxicity (2024)
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Kidney Hypoplasia Increases Kidney Injury following Reversal of Unilateral Ureteral Obstruction (2024)
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O74 EPOXYEICOSATRIENOIC ACIDS ANALOGUE (EET-A) FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED HEART FAILURE WITH NEPHROTIC SYNDROME (2024)
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Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats (2024)
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Attenuation of renal injury by administration of TK-850, a dual inhibitor of TGFβR1/MAP4K4 (2024)
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Novel compounds that target epoxyeicosanoids protect rat kidney epithelial cells in organ transplant solution during cold storage (2024)
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Unraveling mechanisms underlying VEGF-TKI inhibitor related nephrotoxicity and protection by EET analogs: identifying key genes using RNA seq in mesangial cells (2024)
ARA Academy 2022 ARA Scholar
Dr. Imig joined UAMS in 2022 from the Medical College of Wisconsin, where he directed the Drug Discovery Center. His research addresses conditions affecting the heart, metabolism, and kidneys. He maintains active NIH funding and has published approximately 250 articles and holds six U.S. patents with additional applications pending.
Policy Impact
Recruited from the Medical College of Wisconsin with active NIH funding, approximately 250 publications, and six U.S. patents — expanding Arkansas's drug discovery capacity.
Growth Areas
['Population Health Innovations & Clinical Research']
Federal Grants 2 $698,479 total
NIH/National Center for Advancing Translational Sciences
Contact PI
Jul 2024 - Jun 2029
CTSA Postdoctoral T32 at University of Arkansas for Medical Sciences
NIH/National Institute of Diabetes and Digestive and Kidney Diseases
Contact PI
Jun 2021 - May 2027
Endothelial Epoxygenase, Kidney Injury, and Blood Pressure Regulation
Grants & Funding
- CTSA Postdoctoral T32 at University of Arkansas for Medical Sciences NIH/National Center for Advancing Translational Sciences Principal Investigator
- Epoxyeicosanoids and Renal Vascular Function in Obesity &Hypertension NIH Principal Investigator
- Theophylline Prophylaxis during Hypothermia to Limit Neonatal Nephron Damage NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases - Pass Through: Medical College of Wisconsin Principal Investigator
- Endothelial Epoxygenase, Kidney Injury, and Blood Pressure Regulation NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
- Endothelial Epoxygenase, Kidney Injury, and Blood Pressure Regulation NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases Principal Investigator
- Role of p66Shc in Regulation of Microvascular Reactivity of Renal Blood Vessels NIH/Nat. Heart, Lung & Blood Institute - Pass Through: Medical College of Wisconsin Principal Investigator
- CTSA Postdoctoral T32 at University of Arkansas for Medical Sciences NIH/National Center for Advancing Translational Sciences Principal Investigator
- OXYGENASE METABOLITES AND RENAL VASCULAR ACTIVITY NIH Principal Investigator
Collaboration Network
Top Collaborators
Samaneh Goorani
University of Arkansas Medical Center
17 shared publications
In database
- Hypertension: A Continuing Public Healthcare Issue
- Salt-sensitive hypertension after reversal of unilateral ureteral obstruction
- Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences
- <scp>Multi‐target</scp> Drugs to Treat Metabolic Diseases
- Lack of Kidney Injury Sex Differences in Unilateral Ureter Obstructed Mice
Showing 5 of 17 shared publications
Abdul H. Khan
University of Arkansas for Medical Sciences
9 shared publications
In database
- Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity
- Loss of Chloride Channel 6 (CLC-6) Affects Vascular Smooth Muscle Contractility and Arterial Stiffness via Alterations to Golgi Calcium Stores
- Salt-sensitive hypertension after reversal of unilateral ureteral obstruction
- Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences
- Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis
Showing 5 of 9 shared publications
Bruce D. Hammock
UC Davis Comprehensive Cancer Center
7 shared publications
- Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity
- Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats
- Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death
- Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib Induced Cell Death
- Unraveling mechanisms underlying VEGF-TKI inhibitor related nephrotoxicity and protection by EET analogs: identifying key genes using RNA seq in mesangial cells
Showing 5 of 7 shared publications
Abhishek Mishra
University of Arkansas for Medical Sciences
7 shared publications
In database
- Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences
- Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death
- Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib Induced Cell Death
- The Immune System in Nephrotoxicity
- 591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice
Showing 5 of 7 shared publications
Luděk Červenka
Institute of Clinical and Experimental Medicine (CZ)
6 shared publications
- Epoxylipids and soluble epoxide hydrolase in heart diseases
- Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
- Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats
- Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats
- Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats
Showing 5 of 6 shared publications
John R. Falck
The University of Texas Southwestern Medical Center (US)
6 shared publications
- Kidney-Targeted Epoxyeicosatrienoic Acid Analog, EET-F01, Reduces Inflammation, Oxidative Stress, and Cisplatin-Induced Nephrotoxicity
- Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
- Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats
- Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats
- Novel compounds that target epoxyeicosanoids protect rat kidney epithelial cells in organ transplant solution during cold storage
Showing 5 of 6 shared publications
Wojciech K. Jankiewicz
5 shared publications
- Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity
- Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats
- Salt-sensitive hypertension after reversal of unilateral ureteral obstruction
- Abstract 10030: A Novel Multi-Target Drug Prevents Cancer Therapy-Induced Hypertension and Renal Damage
- Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice
Anna Stavniichuk
The University of Texas Health Science Center at Houston (US)
4 shared publications
- Dual sEH/COX-2 Inhibition Using PTUPB—A Promising Approach to Antiangiogenesis-Induced Nephrotoxicity
- Multitarget molecule, PTUPB, to treat diabetic nephropathy in rats
- Salt-sensitive hypertension after reversal of unilateral ureteral obstruction
- Dual soluble epoxide hydrolase inhibitor – farnesoid X receptor agonist interventional treatment attenuates renal inflammation and fibrosis
Olga Gawryś
Institute of Clinical and Experimental Medicine (CZ)
4 shared publications
- Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
- Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats
- Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats
- O74 EPOXYEICOSATRIENOIC ACIDS ANALOGUE (EET-A) FOR THE TREATMENT OF CHEMOTHERAPY-INDUCED HEART FAILURE WITH NEPHROTIC SYNDROME
Ashraf El‐Meanawy
Medical College of Wisconsin (US)
4 shared publications
- Salt-sensitive hypertension after reversal of unilateral ureteral obstruction
- Kidney Injury by Unilateral Ureteral Obstruction in Mice Lacks Sex Differences
- Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib Induced Cell Death
- Dual acting inhibitor of soluble epoxide hydrolase and Cyclooxygenase-2, attenuates glomerular injury in renal hypoplasia mice
Marcus de Bourg
University of Oslo (NO)
4 shared publications
- Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death
- Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib Induced Cell Death
- Unraveling mechanisms underlying VEGF-TKI inhibitor related nephrotoxicity and protection by EET analogs: identifying key genes using RNA seq in mesangial cells
- EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage
Anders Vik
University of Oslo (NO)
4 shared publications
- Synthetic Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib-Induced Cell Death
- Epoxyeicosatrienoic Acid Mimics Protect Mesangial Cells from Sorafenib Induced Cell Death
- Unraveling mechanisms underlying VEGF-TKI inhibitor related nephrotoxicity and protection by EET analogs: identifying key genes using RNA seq in mesangial cells
- EET-Based Therapeutics Mitigate Sorafenib-Associated Glomerular Cell Damage
Henry A. Palfrey
University of Arkansas for Medical Sciences
4 shared publications
In database
- 557 Dual TGFβR1/MAP4K4 inhibitor reduces kidney injury in a mouse model of renal fibrosis.
- Attenuation of renal injury by administration of TK-850, a dual inhibitor of TGFβR1/MAP4K4
- 591 Low kidney mass contributes to enhanced fractionated irradiation-induced renal hemodynamic dysfunction in mice
- Transforming growth factor β receptor 1 and mitogen-activated protein 4 kinase 4 dual inhibitor, TK-850, reduces renal fibrosis in unilateral ureteral–obstructed mice
Janusz Sadowski
Institute of Clinical and Experimental Medicine (CZ)
3 shared publications
- Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
- Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats
- Characterization of a new model of chemotherapy-induced heart failure with reduced ejection fraction and nephrotic syndrome in Ren-2 transgenic rats
Elżbieta Kompanowska‐Jezierska
Mossakowski Medical Research Institute, Polish Academy of Sciences (PL)
3 shared publications
- Effects of Epoxyeicosatrienoic Acid-Enhancing Therapy on the Course of Congestive Heart Failure in Angiotensin II-Dependent Rat Hypertension: From mRNA Analysis towards Functional In Vivo Evaluation
- Early Renal Vasodilator and Hypotensive Action of Epoxyeicosatrienoic Acid Analog (EET-A) and 20-HETE Receptor Blocker (AAA) in Spontaneously Hypertensive Rats
- Epoxyeicosatrienoic Acid Analog and 20-HETE Antagonist Combination Prevent Hypertension Development in Spontaneously Hypertensive Rats
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