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Research Areas
Biography and Research Information
OverviewAI-generated summary
Rushita A. Bagchi's research investigates the mechanisms underlying cardiovascular and renal diseases, with a particular focus on the role of histone deacetylase (HDAC) inhibition and metabolic reprogramming. Her work explores how interventions like HDAC inhibition can reverse existing diastolic dysfunction and prevent long-term consequences of acute kidney injury. Studies led by Bagchi have examined the impact of HDAC inhibition on extracellular matrix remodeling and leptin sensitivity, contributing to an understanding of obesity and metabolic health.
Her recent publications also delve into the cellular and metabolic changes associated with age-related lung fibrosis, including the role of mitochondrial uncoupling protein-2 in inducing oxidative stress and myofibroblast senescence. Bagchi's group has also investigated sex-based differences in cardiorenal outcomes following ischemia-reperfusion injury. She leads a research group at the University of Arkansas for Medical Sciences and has a publication record including 95 papers and over 1,700 citations, with an h-index of 26. Her key collaborators include Shahnaz Ibrahim, S Ibrahim, Ashim K. Bagchi, and Se‐Ran Jun, all from the University of Arkansas for Medical Sciences.
Metrics
- h-index: 26
- Publications: 96
- Citations: 1,737
Selected Publications
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A Defined and Cost-Efficient Strategy for Generating Functionally Quiescent Human iPSC-Derived Cardiac Fibroblasts (2026)
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3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease (2025)
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Temporal Dynamics of Extracellular Matrix Remodeling in Anthracycline-Induced Cardiotoxicity (2025)
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Interplay between stress, chloride homeostasis, and cardiovascular regulation (2025)
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Simulating Cardiometabolic Disease in a 3D-Microenvironment: Human Cardiac Fibroblast Response to Nutritional Stress (2025)
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Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk (2025)
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Obesity, histone acetylation, and insulin resistance (2024)
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List of contributors (2024)
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Histone Deacetylases in Metabolism: the Known and the Unexplored (2024)
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Proteomics Approach to Identify Anthracycline-induced Cardiotoxicity Mechanisms in Human Cardiac Fibroblasts (2024)
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Scleraxis and fibrosis in the pressure-overloaded heart (2022)
Grants & Funding
Collaboration Network
Top Collaborators
Timothy A. McKinsey
University of Colorado Anschutz Medical Campus (US)
9 shared publications
- HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
- Histone deacetylase 6 inhibition restores leptin sensitivity and reduces obesity
- Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling
- Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
Showing 5 of 9 shared publications
Maria A. Cavasin
University of Colorado Anschutz Medical Campus (US)
5 shared publications
- HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
- Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
- BRD4 inhibition rewires cardiac macrophages toward a protective phenotype marked by low MHC class II expression
- Elucidating the molecular mechanisms and cellular specificity of HDAC inhibitor efficacy in diastolic dysfunction
Sara A. Wennersten
University of Colorado Anschutz Medical Campus (US)
4 shared publications
- HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
- Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
- Elucidating the molecular mechanisms and cellular specificity of HDAC inhibitor efficacy in diastolic dysfunction
Emma Robinson
University of Colorado Anschutz Medical Campus (US)
4 shared publications
- Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling
- HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
- Gravi-D peptide disrupts HDAC11 association with an AKAP to stimulate adipocyte thermogenic signaling
- HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
Ryan Holdiness
University of Arkansas for Medical Sciences
4 shared publications
In database
- 3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease
- Proteomics Approach to Identify Anthracycline-induced Cardiotoxicity Mechanisms in Human Cardiac Fibroblasts
- Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk
- Simulating Cardiometabolic Disease in a 3D-Microenvironment: Human Cardiac Fibroblast Response to Nutritional Stress
Christopher Altmann
University of Colorado Denver (US)
3 shared publications
- Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
- Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion
Christian Steinkühler
Italfarmaco (Italy) (IT)
3 shared publications
- HDAC Inhibition Reverses Preexisting Diastolic Dysfunction and Blocks Covert Extracellular Matrix Remodeling
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
- Elucidating the molecular mechanisms and cellular specificity of HDAC inhibitor efficacy in diastolic dysfunction
Sarah Faubel
University of Colorado Denver (US)
3 shared publications
- Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
- Lung metabolomics after ischemic acute kidney injury reveals increased oxidative stress, altered energy production, and ATP depletion
Jennifer L. Major
University of Colorado Anschutz Medical Campus (US)
3 shared publications
- Reversible lysine fatty acylation of an anchoring protein mediates adipocyte adrenergic signaling
- HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
- HDAC11 inhibition triggers bimodal thermogenic pathways to circumvent adipocyte catecholamine resistance
Ashim K. Bagchi
University of Arkansas for Medical Sciences
3 shared publications
In database
- Proteomics Approach to Identify Anthracycline-induced Cardiotoxicity Mechanisms in Human Cardiac Fibroblasts
- List of contributors
- Obesity, histone acetylation, and insulin resistance
Anya Dhar
University of Michigan–Ann Arbor (US)
3 shared publications
- Proteomics Approach to Identify Anthracycline-induced Cardiotoxicity Mechanisms in Human Cardiac Fibroblasts
- List of contributors
- Obesity, histone acetylation, and insulin resistance
Shahnaz Ibrahim
University of Arkansas for Medical Sciences
3 shared publications
In database
- Histone Deacetylases in Metabolism: the Known and the Unexplored
- Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk
- Simulating Cardiometabolic Disease in a 3D-Microenvironment: Human Cardiac Fibroblast Response to Nutritional Stress
Kristen E. Boyle
University of Colorado Anschutz Medical Campus (US)
3 shared publications
- 3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease
- Global Transcriptional Profiling of Adipose Tissue Uncovers Unique Sex-Dependent Mechanisms in Acute Obesity: Implications for Adipose-Heart Interorgan Crosstalk
- Simulating Cardiometabolic Disease in a 3D-Microenvironment: Human Cardiac Fibroblast Response to Nutritional Stress
S Ibrahim
University of Arkansas for Medical Sciences (US)
3 shared publications
- Temporal Dynamics of Extracellular Matrix Remodeling in Anthracycline-Induced Cardiotoxicity
- 3-D biomechanics and epigenomics reveal atypical fibroblast responses in cardiometabolic disease
- Interplay between stress, chloride homeostasis, and cardiovascular regulation
Danielle E. Soranno
University of Colorado Denver (US)
2 shared publications
- Female and male mice have differential longterm cardiorenal outcomes following a matched degree of ischemia–reperfusion acute kidney injury
- Acute Kidney Injury Results in Long-Term Diastolic Dysfunction That Is Prevented by Histone Deacetylase Inhibition
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