Kevin D. Raney

Sourced from institutional research profiles (UAMS TRI or ARA).

Federal Grant PI High Impact

Department Chairperson

UAMS primary UA Little Rock Hendrix College

Also affiliated: University of North Carolina at Chapel Hill (2021); Pennsylvania State University (1994–2008); University of Arizona (2003); Vanderbilt University (1989–2002); University of Arkansas Medical Center (2010–2024); Princess Anne Hospital (2024); University Hospital Southampton NHS Foundation Trust (2024); Winthrop Rockefeller Foundation (2016–2021); Epoch Biosciences (United States) (2003); Conway School of Landscape Design (2000); Arkansas Department of Agriculture (2014); University of Chinese Academy of Sciences (2009)

Faculty Researcher

Department Chairs, College of Medicine

43 h-index 130 pubs 4,724 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

Kevin D. Raney's research focuses on the mechanisms of helicases and their interactions with nucleic acids, particularly G-quadruplexes. He has received significant federal funding from the NIH/National Institute of General Medical Sciences for projects investigating the functions and mechanisms of these enzymes and their roles in G-quadruplex nucleic acid signaling. His work has led to publications detailing how viral proteins, such as the Hepatitis C virus nonstructural protein NS3, interact with and unfold viral G-quadruplex RNA structures. Further investigations explore how G-quadruplex DNA can influence helicase activity and promote phase separation, as observed with the DEAD-box helicase Ded1p. Raney's group also studies the unwinding mechanisms of eukaryotic Pif1 helicases on G-quadruplex and double-stranded DNA, and how these enzymes remodel protein-nucleic acid complexes. His research group includes collaborators such as John C. Marecki, Alicia K. Byrd, and Jun Gao from the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications. Raney is recognized as a high-impact researcher with an h-index of 43 and over 4,700 citations.

Metrics

h-index: 43
Publications: 130
Citations: 4,724

Selected Publications

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism (2026)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2026)

Science Advances DOI OpenAlex
RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2026)

Cell Reports DOI OpenAlex
Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2025)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025)

Nucleic Acids Research 4 citations DOI OpenAlex
Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2025)

Research Square 1 citation DOI OpenAlex
RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2025)

bioRxiv (Cold Spring Harbor Laboratory) 2 citations DOI OpenAlex
A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025)

bioRxiv (Cold Spring Harbor Laboratory) 1 citation DOI OpenAlex
Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction (2024)

Nucleic Acids Research 1 citation DOI OpenAlex
Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2024)

bioRxiv (Cold Spring Harbor Laboratory) 6 citations DOI OpenAlex
Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)

Nature Communications 9 citations DOI OpenAlex
Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024)

Nucleic Acids Research 2 citations DOI OpenAlex
Autophosphorylation of the Tousled-like kinases TLK1 and TLK2 regulates recruitment to damaged chromatin via PCNA interaction (2024)

bioRxiv (Cold Spring Harbor Laboratory) 1 citation DOI OpenAlex
Pif1 Helicase Mediates Remodeling of Protein-Nucleic Acid Complexes by Promoting Dissociation of Sub1 from G-Quadruplex DNA and Cdc13 from G-Rich Single-Stranded DNA (2023)

Biochemistry 9 citations DOI OpenAlex
Hepatitis C virus nonstructural protein NS3 unfolds viral G-quadruplex RNA structures (2022)

Journal of Biological Chemistry 11 citations DOI OpenAlex