S
Seongok Lee
Post Doctoral Fellow
postdoc
Radiation Oncology, College of Medicine
3 h-index
14 pubs
124 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Seongok Lee's research focuses on cellular mechanisms related to DNA repair, protein homeostasis, and organ transplantation. Lee has investigated the role of ZMYM2 in restricting 53BP1 at DNA double-strand breaks to facilitate BRCA1 loading and homologous recombination, and the regulation of 53BP1 recruitment at damaged chromatin by evolved histone tails. Further work examines how UBA80 and UBA52 influence RNF168-dependent histone ubiquitination and DNA repair. In the context of transplantation, Lee's work includes studying the immunoproteasome in rat kidney allografts and its impact on function after cold storage and transplantation. Research also explores the role of Complement 5 in mitochondria during kidney ischemia-reperfusion injury in rats and the mitigation of post-ischemia and reperfusion kidney injury in complement 5 knockout rats. Lee's scholarship includes 13 publications with 123 citations and an h-index of 3.
Metrics
- h-index: 3
- Publications: 14
- Citations: 124
Selected Publications
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Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats (2025)
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Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat (2025)
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Mechanism of Impaired Protein Homeostasis in Kidney Grafts Following Cold Storage and Transplantation (Abstract ID: 162640) (2025)
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Ischemia and Reperfusion (IRI)-Induced Kidney Injury Is Attenuated by Complement 5 Gene Deletion (Abstract ID: 161749) (2025)
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Mechanism of Impaired Protein Homeostasis in Kidney Grafts following Cold Storage and Transplant (2024)
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Evolved histone tail regulates 53BP1 recruitment at damaged chromatin (2024)
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Normal Proteasome Function Is Needed to Prevent Kidney Graft Injury during Cold Storage Followed by Transplantation (2024)
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Cold Storage Followed by Transplantation Induces Immunoproteasome in Rat Kidney Allografts: Inhibition of Immunoproteasome Does Not Improve Function (2024)
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Ischemia-Reperfusion-Mediated Kidney Injury Is Attenuated in a New Complement 5 Knockout Model (2023)
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Cold Storage-Mediated p38MAPK Activation: A Potential Contributor of Proteasome Dysfunction and Kidney Damage After Transplantation (2023)
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Mechanism of Cold Storage-Mediated Regulation of Heat Shock Proteins in Renal Grafts After Transplantation (2023)
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UBA80 and UBA52 fine-tune RNF168-dependent histone ubiquitination and DNA repair (2023)
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ZMYM2 restricts 53BP1 at DNA double-strand breaks to favor BRCA1 loading and homologous recombination (2022)
Collaboration Network
Top Collaborators
Nirmala Parajuli
University of Arkansas for Medical Sciences
8 shared publications
In database
- Mechanism of Cold Storage-Mediated Regulation of Heat Shock Proteins in Renal Grafts After Transplantation
- Cold Storage-Mediated p38MAPK Activation: A Potential Contributor of Proteasome Dysfunction and Kidney Damage After Transplantation
- Ischemia-Reperfusion-Mediated Kidney Injury Is Attenuated in a New Complement 5 Knockout Model
- Mechanism of Impaired Protein Homeostasis in Kidney Grafts following Cold Storage and Transplant
- Ischemia and Reperfusion (IRI)-Induced Kidney Injury Is Attenuated by Complement 5 Gene Deletion (Abstract ID: 161749)
Showing 5 of 8 shared publications
Dinesh Bhattarai
University of Arkansas for Medical Sciences
5 shared publications
In database
- Cold Storage-Mediated p38MAPK Activation: A Potential Contributor of Proteasome Dysfunction and Kidney Damage After Transplantation
- Ischemia-Reperfusion-Mediated Kidney Injury Is Attenuated in a New Complement 5 Knockout Model
- Ischemia and Reperfusion (IRI)-Induced Kidney Injury Is Attenuated by Complement 5 Gene Deletion (Abstract ID: 161749)
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
- Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats
Madison McGraw
University of Arkansas for Medical Sciences
4 shared publications
In database
- Ischemia-Reperfusion-Mediated Kidney Injury Is Attenuated in a New Complement 5 Knockout Model
- Ischemia and Reperfusion (IRI)-Induced Kidney Injury Is Attenuated by Complement 5 Gene Deletion (Abstract ID: 161749)
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
- Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats
Han Na Jang
Seonam University (KR)
2 shared publications
- 725-P: Low Fasting Glucose and Insulin Deficiency Were Related with Superiority of Insulin Degludec/Aspart Compared with Basal Insulin in Patients with Type 2 Diabetes
- 834-P: A Prospective Study on Switching from Basal Insulin to Insulin Degludec/Insulin Aspart, in Patients with Type 2 Diabetes Whose FPG Levels Are Lower Than Those Predicted by Their HbA1c
Ye Yang
Seonam University (KR)
2 shared publications
- 725-P: Low Fasting Glucose and Insulin Deficiency Were Related with Superiority of Insulin Degludec/Aspart Compared with Basal Insulin in Patients with Type 2 Diabetes
- 834-P: A Prospective Study on Switching from Basal Insulin to Insulin Degludec/Insulin Aspart, in Patients with Type 2 Diabetes Whose FPG Levels Are Lower Than Those Predicted by Their HbA1c
Gopinath Venugopal
University of Arkansas for Medical Sciences (US)
2 shared publications
- Mechanism of Impaired Protein Homeostasis in Kidney Grafts Following Cold Storage and Transplantation (Abstract ID: 162640)
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
Amod Sharma
University of Arkansas for Medical Sciences (US)
2 shared publications
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
- Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats
Neriman Gokden
University of Arkansas for Medical Sciences (US)
2 shared publications
- Post‐ischemia and reperfusion kidney injury is mitigated in a novel complement 5 knockout rat
- Complement 5's Role in Mitochondria During Kidney Ischemia-Reperfusion Injury in Rats
Tae Jung Oh
Seonam University (KR)
1 shared publication
- 725-P: Low Fasting Glucose and Insulin Deficiency Were Related with Superiority of Insulin Degludec/Aspart Compared with Basal Insulin in Patients with Type 2 Diabetes
Bo Kyung Koo
Seonam University (KR)
1 shared publication
- 725-P: Low Fasting Glucose and Insulin Deficiency Were Related with Superiority of Insulin Degludec/Aspart Compared with Basal Insulin in Patients with Type 2 Diabetes
Hye Seung Jung
Seonam University (KR)
1 shared publication
- 725-P: Low Fasting Glucose and Insulin Deficiency Were Related with Superiority of Insulin Degludec/Aspart Compared with Basal Insulin in Patients with Type 2 Diabetes
EUNSHIL HONG
Seonam University (KR)
1 shared publication
- 834-P: A Prospective Study on Switching from Basal Insulin to Insulin Degludec/Insulin Aspart, in Patients with Type 2 Diabetes Whose FPG Levels Are Lower Than Those Predicted by Their HbA1c
Soo Heon Kwak
Seonam University (KR)
1 shared publication
- 834-P: A Prospective Study on Switching from Basal Insulin to Insulin Degludec/Insulin Aspart, in Patients with Type 2 Diabetes Whose FPG Levels Are Lower Than Those Predicted by Their HbA1c
KYONG SOO PARK
Seonam University (KR)
1 shared publication
- 834-P: A Prospective Study on Switching from Basal Insulin to Insulin Degludec/Insulin Aspart, in Patients with Type 2 Diabetes Whose FPG Levels Are Lower Than Those Predicted by Their HbA1c
Hak Chul Jang
Seonam University (KR)
1 shared publication
- 834-P: A Prospective Study on Switching from Basal Insulin to Insulin Degludec/Insulin Aspart, in Patients with Type 2 Diabetes Whose FPG Levels Are Lower Than Those Predicted by Their HbA1c
Similar Researchers
Based on overlapping research topics
Dinesh Bhattarai
University of Arkansas for Medical Sciences
Protein Degradation and Inhibitors
Organ Transplantation Techniques and Outcomes
Immune Response and Inflammation
Nirmala Parajuli
University of Arkansas for Medical Sciences
Protein Degradation and Inhibitors
Organ Transplantation Techniques and Outcomes
Immune Response and Inflammation
Sorena Lo
University of Arkansas for Medical Sciences
Organ Transplantation Techniques and Outcomes
Immune Response and Inflammation
Mitochondrial Function and Pathology
Clara M. Stiefel
University of Arkansas for Medical Sciences
DNA Repair Mechanisms
Immune Response and Inflammation
Mitochondrial Function and Pathology
Bertha Osei
University of Arkansas for Medical Sciences
DNA Repair Mechanisms
Immune Response and Inflammation
Mitochondrial Function and Pathology
S.W. Lee
University of Arkansas for Medical Sciences
Protein Degradation and Inhibitors
Organ Transplantation Techniques and Outcomes
Immune Response and Inflammation