L
Lei Guo Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
High Impact
Research Biologist
faculty
52 h-index
203 pubs
17,977 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Lei Guo's research focuses on understanding the metabolic pathways and toxicological effects of various chemical compounds, with a particular emphasis on liver toxicity and drug metabolism. Guo has investigated the genotoxicity potential of compounds like luteolin, examining the role of specific cytochrome P450 enzymes (CYP1A1, CYP1A2) in this process. Further work has explored the cellular resistance mechanisms involving drug-metabolizing enzymes such as CYP3A4 and CYP3A5, and their implications for cytostatic resistance.
Guo has also characterized genetically modified HepG2 cells that overexpress cytochrome P450 enzymes. This work aims to create more accurate models for assessing drug and chemical-induced liver toxicity in vitro. Recent studies have examined the in vitro effects and transcriptomic changes induced by cannabidiol in human Sertoli cells, as well as its metabolism and liver toxicity. Additional research includes the impact of urea and fulvic acid solutions on maize carbon and nitrogen metabolism.
Metrics
- h-index: 52
- Publications: 203
- Citations: 17,977
Selected Publications
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Translating in vitro mechanistic findings to in vivo toxicity outcomes: A case study of Usnic acid hepatotoxicity (2026)
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Potential anticancer effects and toxicity of flavones luteolin and apigenin <i>in vivo</i> (2025)
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7-Hydroxycannabidiol and 7-carboxycannabidiol induced cytotoxicity via apoptosis and endoplasmic reticulum stress in human hepatic cells (2025)
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Comparing the cannabidiol-induced transcriptomic profiles in human and mouse Sertoli cells (2025)
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Metabolism and liver toxicity of cannabidiol (2024)
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Hepatotoxicity of usnic acid and underlying mechanisms (2024)
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Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells (2024)
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CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism (2024)
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CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism (2024)
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Use of Lentivirus‐Based Method for Establishing TK6 Human Cell Lines Expressing Cytochrome P450 and its Applications in Genotoxicity Testing (2024)
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Evaluation of weak genotoxicity of hydroxychloroquine in human TK6 cells (2024)
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Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells (2023)
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The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib (2023)
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Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches (2023)
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2021–2022<i>Toxicological Sciences</i>paper of the year (2023)
Collaboration Network
Top Collaborators
Si Chen
National Center for Toxicological Research
18 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Roles of CYP3A4, CYP3A5 and CYP2C8 drug-metabolizing enzymes in cellular cytostatic resistance
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
Showing 5 of 18 shared publications
Yuxi Li
National Center for Toxicological Research (US)
13 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
Showing 5 of 13 shared publications
Xuan Qin
Baylor College of Medicine (US)
11 shared publications
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline
- Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches
- CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism
Showing 5 of 11 shared publications
Nan Mei
National Center for Toxicological Research
10 shared publications
In database
- The genotoxicity potential of luteolin is enhanced by CYP1A1 and CYP1A2 in human lymphoblastoid TK6 cells
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- The expression of Phase II drug-metabolizing enzymes in human B-lymphoblastoid TK6 cells
- Genotoxicity evaluation of nutraceuticals
Showing 5 of 10 shared publications
Feng Li
Baylor College of Medicine (US)
10 shared publications
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Study of the roles of cytochrome P450 (CYPs) in the metabolism and cytotoxicity of perhexiline
- Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches
- CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism
Showing 5 of 10 shared publications
Xilin Li
Genetic Analysis (Norway) (NO)
9 shared publications
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- The involvement of hepatic cytochrome P450s in the cytotoxicity of lapatinib
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
Showing 5 of 9 shared publications
John M. Hakenjos
Baylor College of Medicine (US)
8 shared publications
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
- Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches
- CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism
- Metabolomics reveals a unique CYP3A-mediated C(sp3)-C(sp2) bond cleavage via ipso-addition reaction in drug metabolism
- CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism
Showing 5 of 8 shared publications
Kevin R. MacKenzie
Baylor College of Medicine (US)
8 shared publications
- Metabolism of a Selective Serotonin and Norepinephrine Reuptake Inhibitor Duloxetine in Liver Microsomes and Mice
- Identifying the Reactive Metabolites of Tyrosine Kinase Inhibitor Pexidartinib In Vitro Using LC–MS-Based Metabolomic Approaches
- CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism
- Metabolomics reveals a unique CYP3A-mediated C(sp3)-C(sp2) bond cleavage via ipso-addition reaction in drug metabolism
- CYP3A Mediates an Unusual C(sp<sup>2</sup>)−C(sp<sup>3</sup>) Bond Cleavage via <i>Ipso</i>‐Addition of Oxygen in Drug Metabolism
Showing 5 of 8 shared publications
Qiangen Wu
National Center for Toxicological Research
7 shared publications
In database
- Characterization of cytochrome P450s (CYP)-overexpressing HepG2 cells for assessing drug and chemical-induced liver toxicity
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Metabolism and liver toxicity of cannabidiol
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Showing 5 of 7 shared publications
Supratim Choudhuri
United States Food and Drug Administration (US)
7 shared publications
- In vitro effects of cannabidiol and its main metabolites in mouse and human Sertoli cells
- Cannabidiol-induced transcriptomic changes and cellular senescence in human Sertoli cells
- Induction of apoptosis by cannabidiol and its main metabolites in human Leydig cells
- Toxicity of cannabidiol and its metabolites in TM3 mouse Leydig cells: a comparison with primary human Leydig cells
- Investigation of cannabidiol-induced cytotoxicity in human hepatic cells
Showing 5 of 7 shared publications
Zhiguang Li
United States Food and Drug Administration (US)
6 shared publications
- Additional file 3 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 2 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 1 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
Showing 5 of 6 shared publications
William S. Branham
United States Food and Drug Administration (US)
6 shared publications
- Additional file 3 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 2 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 1 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
Showing 5 of 6 shared publications
Stacey L. Dial
United States Food and Drug Administration (US)
6 shared publications
- Additional file 3 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 2 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 1 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
Showing 5 of 6 shared publications
Yexun Wang
6 shared publications
- Additional file 3 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 2 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 1 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
Showing 5 of 6 shared publications
Leming Shi
United States Food and Drug Administration (US)
6 shared publications
- Additional file 3 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 2 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
- Additional file 1 of Genomic analysis of microRNA time-course expression in liver of mice treated with genotoxic carcinogen N-ethyl-N-nitrosourea
Showing 5 of 6 shared publications
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