Alexander J. Layman

Researcher

University of Arkansas for Medical Sciences

unknown

2 h-index 4 pubs 30 cited

Research Areas

Drug-Induced Hepatotoxicity and Protection Phytochemicals and Antioxidant Activities Diet and metabolism studies MicroRNA in disease regulation Liver Disease Diagnosis and Treatment Health and Medical Research Impacts Protein Degradation and Inhibitors

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OverviewAI-generated summary

Alexander J. Layman's research focuses on understanding and mitigating hepatotoxicity, particularly concerning acetaminophen overdose and the role of natural products in protection. His work investigates metabolic pathways, such as pyruvate and alanine metabolism in the liver, which are crucial for maintaining antioxidant capacity and resilience against oxidative stress. Layman also explores the molecular mechanisms underlying disease, including the upregulation of microRNA-21 in lymphatic malformation endothelial cells and its inhibition of PDCD4. His recent publications call for increased rigor in preclinical studies of dietary supplements intended to protect against acetaminophen-induced liver damage and address the detection and diagnosis of hepatotoxicity in both experimental and clinical contexts. Layman has collaborated with researchers including Mitchell R. McGill, Igor Koturbash, Scott Alsbrook, and Eric U. Yee at the University of Arkansas for Medical Sciences.

Metrics

  • h-index: 2
  • Publications: 4
  • Citations: 30

Selected Publications

  • Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025) DOI
  • Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024) DOI
  • Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023) DOI

Collaborators

Researchers in the database who share publications

Mitchell R. McGill University of Arkansas for Medical Sciences 3 shared publications Igor Koturbash University of Arkansas for Medical Sciences 1 shared publication Scott Alsbrook University of Arkansas for Medical Sciences 1 shared publication Eric U. Yee University of Arkansas for Medical Sciences 1 shared publication Felicia D. Allard University of Arkansas for Medical Sciences 1 shared publication Jake R. Price University of Arkansas for Medical Sciences 1 shared publication Stefanie Kennon‐McGill University of Arkansas for Medical Sciences 1 shared publication Gresham T. Richter University of Arkansas for Medical Sciences 1 shared publication

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