Biography and Research Information
OverviewAI-generated summary
Alexander J. Layman's research investigates the metabolic pathways involved in maintaining antioxidant capacity and resistance to oxidative stress, with a particular focus on the roles of hepatic pyruvate and alanine metabolism. His work also examines the molecular mechanisms driving cell proliferation, such as the upregulation of microRNA-21 and its inhibition of PDCD4 in lymphatic malformation endothelial cells.
Layman has also contributed to the scientific discourse on hepatotoxicity, advocating for increased rigor in preclinical studies of dietary supplements and contributing to the detection and diagnosis of liver toxicity in both experimental and clinical settings. His scholarship metrics include an h-index of 2, with 4 publications and 31 citations. He has collaborated with researchers at the University of Arkansas for Medical Sciences, including Mitchell R. McGill, Igor Koturbash, Scott Alsbrook, and Eric U. Yee.
Metrics
- h-index: 2
- Publications: 4
- Citations: 32
Selected Publications
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Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings (2025)
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Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements (2024)
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Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult (2023)
Collaboration Network
Top Collaborators
Mitchell R. McGill
Arkansas Department of Health
3 shared publications
In database
- Hepatic pyruvate and alanine metabolism are critical and complementary for maintenance of antioxidant capacity and resistance to oxidative insult
- Natural Products That Protect Against Acetaminophen Hepatotoxicity: A Call for Increased Rigor in Preclinical Studies of Dietary Supplements
- Detection and Diagnosis of Hepatotoxicity in Experimental and Clinical Settings
Ravi W. Sun
University of Arkansas for Medical Sciences
1 shared publication
In database
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Haihong Zhang
University of Arkansas for Medical Sciences
1 shared publication
In database
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Syed J. Mehdi
University of Arkansas for Medical Sciences (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Gresham T. Richter
University of Arkansas for Medical Sciences
1 shared publication
In database
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Hayden H. Bowman
Arkansas Children's Hospital
1 shared publication
In database
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Jessica Sifford
Arkansas Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Chelsea Smith
Arkansas Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Alexander K. Burnett
Arkansas Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Charity L. Washam
Arkansas Children's Hospital
1 shared publication
In database
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Stephanie D. Byrum
Arkansas Children's Hospital
1 shared publication
In database
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
James T. Bennett
Seattle Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Dana M. Jensen
Seattle Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Victoria Dmyterko
Seattle Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
Jonathan A. Perkins
Seattle Children's Hospital (US)
1 shared publication
- Upregulated MicroRNA-21 Drives the Proliferation of Lymphatic Malformation Endothelial Cells by Inhibiting PDCD4
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Based on overlapping research topics
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