Match tier Confirmed
Presence Current · Arkansas
Last published 2026
Sources OpenAlex · ORCID
Refreshed 2026-08-20

Narasimhan Rajaram

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Federal Grant PI High Impact

Professor

Also affiliated: Duke University (2011–2018); University of Arkansas System (2023); In-Q-Tel (2016); Winthrop Rockefeller Foundation (2021–2024); Optica (2018–2019); The University of Texas at Austin (2007–2014)

Faculty Researcher

24 h-index 127 pubs 1,913 cited

  • Humans
  • Animals
  • Mice
  • Female
  • Spectrum Analysis
  • Cell Line, Tumor
  • Optical Imaging
  • Oxygen
  • Skin Neoplasms
  • Spectrometry, Fluorescence
  • Radiation Tolerance
  • Reproducibility of Results
  • Equipment Design
  • Breast Neoplasms
  • Disease Models, Animal

Biography and Research Information

OverviewAI-generated summary

Narasimhan Rajaram's research focuses on the application of optical spectroscopy techniques, particularly diffuse reflectance spectroscopy, for noninvasive monitoring and characterization of biological tissues and disease states. His work has investigated changes in tumor microenvironments in response to various treatments, including radiation and immune checkpoint inhibitors, and has explored the optical properties of different tumor types in murine models. Rajaram has also examined heat stress-induced changes in hemoglobin concentration in chicken breast and the use of terahertz imaging for breast cancer evaluation in rats.

His federally funded projects include significant support from the NIH for the Arkansas Integrative Metabolic Research Center and for the determination of functional and molecular biomarkers of treatment resistance using multimodal optical spectroscopy. Additionally, an NSF grant supports the development of a multimodal imaging platform for bioenergetics in live tissue. Rajaram's scholarship metrics include an h-index of 24, 127 total publications, and 1,901 total citations, designating him as a highly cited researcher.

Metrics

  • h-index: 24
  • Publications: 127
  • Citations: 1,913

Selected Publications

  • Abstract 7625: Development of a blood-based tumor hypoxia detection assay (2026)
    Cancer Research DOI OpenAlex
  • Optical metabolic imaging of tumor recurrence in non-small cell lung cancer (2026)
  • Metabolic Imaging and Characterization of Multicomponent Spheroid Models in Vitro. (2025)
  • Advancing Optical Techniques for Cancer Diagnosis and Therapy Monitoring (2025)
    Biophotonics discovery. DOI OpenAlex
  • Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling (2025)
    Journal of Biomedical Optics 11 citations DOI OpenAlex
  • Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy (2025)
  • Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy (2025)
  • Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications (2024)
    Journal of Biophotonics DOI OpenAlex
  • Erratum: Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
    Biophotonics discovery. DOI OpenAlex
  • Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence (2024)
    bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
  • Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy (2024)
    ACS Omega 5 citations DOI OpenAlex
  • Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections (2024)
    Journal of Biophotonics 1 citation DOI OpenAlex
  • Rapid Optical Sensing of Infection in Joint Fluids (2024)
  • Design and Validation of a Multimodal Spatially Offset System Comprising Diffuse Reflectance Spectroscopy and Raman Spectroscopy (2024)
  • Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
    Biophotonics discovery. 4 citations DOI OpenAlex

View all publications on OpenAlex →

Federal Grants 3 $2,550,322 total

NIH Contact PI Apr 2021 - Feb 2031

Arkansas Integrative Metabolic Research Center

National Institute of General Medical Sciences $2,249,100 P20
NIH Contact PI Aug 2019 - Jul 2026

Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopy

National Cancer Institute $251,222 R01

Collaboration Network

97 Collaborators 29 Institutions 4 Countries

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