N
Narasimhan Rajaram Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
High Impact
Professor
faculty
24 h-index
127 pubs
1,888 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Narasimhan Rajaram's research focuses on the application of optical spectroscopy techniques for biomedical applications, particularly in cancer detection and treatment monitoring. He investigates how methods such as diffuse reflectance spectroscopy and Raman spectroscopy can provide insights into tumor microenvironments, cellular phenotypes, and treatment responses. His work includes evaluating optical properties of different tumor types and assessing changes induced by therapies like immunotherapy, radiation, and chemotherapy in various animal models, including mice, rats, and chickens.
Rajaram has received significant federal funding for his research. He is the PI on an NIH/National Institute of General Medical Sciences grant totaling $2,103,742 for the Arkansas Integrative Metabolic Research Center, and an NIH/National Cancer Institute grant of $251,222 to determine functional and molecular biomarkers of treatment resistance using multimodal optical spectroscopy. He also received a $50,000 NSF grant for developing a multimodal imaging platform to image bioenergetics in live tissue.
His publications demonstrate a breadth of application, extending from cancer research to assessing physiological changes in animal tissues and addressing health disparities related to medical devices. Rajaram collaborates with researchers at the University of Arkansas at Fayetteville and the University of Arkansas for Medical Sciences. His scholarship metrics include an h-index of 24, 126 total publications, and 1,875 total citations.
Metrics
- h-index: 24
- Publications: 127
- Citations: 1,888
Selected Publications
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Optical metabolic imaging of tumor recurrence in non-small cell lung cancer (2026)
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Metabolic Imaging and Characterization of Multicomponent Spheroid Models in Vitro. (2025)
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Advancing Optical Techniques for Cancer Diagnosis and Therapy Monitoring (2025)
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Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling (2025)
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Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy (2025)
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Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy (2025)
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Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications (2024)
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Erratum: Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
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Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence (2024)
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Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy (2024)
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Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections (2024)
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Rapid Optical Sensing of Infection in Joint Fluids (2024)
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Design and Validation of a Multimodal Spatially Offset System Comprising Diffuse Reflectance Spectroscopy and Raman Spectroscopy (2024)
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Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
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Racial and skin color mediated disparities in pulse oximetry in infants and young children (2024)
Federal Grants 3 $2,404,964 total
NIH/National Institute of General Medical Sciences
Contact PI
Apr 2021 - Apr 2026
NIH/National Cancer Institute
Contact PI
Aug 2019 - Jul 2026
NSF
PI
Sep 2021 - Feb 2023
I-Corps: Multimodal imaging platform to image bioenergetics in live tissue
Collaboration Network
Top Collaborators
Joel Rodríguez Troncoso
University of Arkansas at Fayetteville
15 shared publications
In database
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer
- Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation
- Terahertz Imaging of Breast Cancer using Human and Animal Models
Showing 5 of 15 shared publications
Ishan Barman
Johns Hopkins University (US)
15 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Optical spectroscopy of murine breast tumors to determine metastatic potential
Showing 5 of 15 shared publications
Santosh Kumar Paidi
Johns Hopkins University (US)
14 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Optical spectroscopy of murine breast tumors to determine metastatic potential
Showing 5 of 14 shared publications
Paola Monterroso Díaz
University of Arkansas at Fayetteville (US)
13 shared publications
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Optical spectroscopy to monitor tumor response to immunotherapy
- Optical imaging of metabolic profiles in responder and non-responder human lung tumors
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
Showing 5 of 13 shared publications
Charles M. Quick
University of Arkansas for Medical Sciences
12 shared publications
In database
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
Showing 5 of 12 shared publications
Jesse D. Ivers
University of Arkansas at Fayetteville
12 shared publications
In database
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
Showing 5 of 12 shared publications
Sina Dadgar
University of Arkansas at Fayetteville (US)
9 shared publications
- Diffuse reflectance spectroscopy reveals heat stress-induced changes in hemoglobin concentration in chicken breast
- Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Diffuse reflectance spectroscopy to study the effects of radiation therapy dose on tumor microenvironment
- Data from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
Showing 5 of 9 shared publications
David E. Lee
University of Arkansas at Fayetteville (US)
8 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Optical spectroscopy to monitor tumor response to immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
Showing 5 of 8 shared publications
Ruud P.M. Dings
University of Arkansas at Fayetteville
8 shared publications
In database
- Abstract 1088: Acquired radiation resistance induces thiol-dependent cisplatin cross-resistance
- Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance
- Data from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Figures SF1 to SF4 and Tables TS1 to TS4 from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Figures SF1 to SF4 and Tables TS1 to TS4 from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
Showing 5 of 8 shared publications
Samir V. Jenkins
7 shared publications
In database
- Abstract 1088: Acquired radiation resistance induces thiol-dependent cisplatin cross-resistance
- Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance
- Data from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Figures SF1 to SF4 and Tables TS1 to TS4 from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Figures SF1 to SF4 and Tables TS1 to TS4 from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
Showing 5 of 7 shared publications
Robert J. Griffin
7 shared publications
- Abstract 1088: Acquired radiation resistance induces thiol-dependent cisplatin cross-resistance
- Acquired Radiation Resistance Induces Thiol-dependent Cisplatin Cross-resistance
- Data from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Figures SF1 to SF4 and Tables TS1 to TS4 from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
- Figures SF1 to SF4 and Tables TS1 to TS4 from Label-Free Raman Spectroscopy Reveals Signatures of Radiation Resistance in the Tumor Microenvironment
Showing 5 of 7 shared publications
Stephanie D. Byrum
University of Arkansas for Medical Sciences
5 shared publications
In database
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence
Varsha Karunakaran
University of Arkansas at Fayetteville
5 shared publications
In database
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Design and Validation of a Multimodal Spatially Offset System Comprising Diffuse Reflectance Spectroscopy and Raman Spectroscopy
- Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications
- Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy
- Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy
Kyle P. Quinn
University of Arkansas at Fayetteville
4 shared publications
In database
- Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling
- Optical imaging of metabolic profiles in responder and non-responder human lung tumors
- Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence
- Optical metabolic imaging of tumor recurrence in non-small cell lung cancer
Piyush Raj
Johns Hopkins University (US)
4 shared publications
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
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