Narasimhan Rajaram
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Professor
Also affiliated: Duke University (2011–2018); University of Arkansas System (2023); In-Q-Tel (2016); Winthrop Rockefeller Foundation (2021–2024); Optica (2018–2019); The University of Texas at Austin (2007–2014)
Faculty Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Narasimhan Rajaram's research focuses on the application of optical spectroscopy techniques, particularly diffuse reflectance spectroscopy, for noninvasive monitoring and characterization of biological tissues and disease states. His work has investigated changes in tumor microenvironments in response to various treatments, including radiation and immune checkpoint inhibitors, and has explored the optical properties of different tumor types in murine models. Rajaram has also examined heat stress-induced changes in hemoglobin concentration in chicken breast and the use of terahertz imaging for breast cancer evaluation in rats.
His federally funded projects include significant support from the NIH for the Arkansas Integrative Metabolic Research Center and for the determination of functional and molecular biomarkers of treatment resistance using multimodal optical spectroscopy. Additionally, an NSF grant supports the development of a multimodal imaging platform for bioenergetics in live tissue. Rajaram's scholarship metrics include an h-index of 24, 127 total publications, and 1,901 total citations, designating him as a highly cited researcher.
Metrics
- h-index: 24
- Publications: 127
- Citations: 1,913
Selected Publications
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Abstract 7625: Development of a blood-based tumor hypoxia detection assay (2026)
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Optical metabolic imaging of tumor recurrence in non-small cell lung cancer (2026)
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Metabolic Imaging and Characterization of Multicomponent Spheroid Models in Vitro. (2025)
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Advancing Optical Techniques for Cancer Diagnosis and Therapy Monitoring (2025)
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Consensus guidelines for cellular label-free optical metabolic imaging: ensuring accuracy and reproducibility in metabolic profiling (2025)
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Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy (2025)
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Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy (2025)
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Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications (2024)
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Erratum: Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
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Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence (2024)
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Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy (2024)
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Noncontact Diffuse Reflectance Spectroscopy of Synovial Fluid Samples for Rapid Identification of Infections (2024)
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Rapid Optical Sensing of Infection in Joint Fluids (2024)
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Design and Validation of a Multimodal Spatially Offset System Comprising Diffuse Reflectance Spectroscopy and Raman Spectroscopy (2024)
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Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy (2024)
Federal Grants 3 $2,550,322 total
I-Corps: Multimodal imaging platform to image bioenergetics in live tissue
Collaboration Network
Top Collaborators
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Mammary tumors in Sprague Dawley rats induced by N-ethyl-N-nitrosourea for evaluating terahertz imaging of breast cancer
- Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation
- Terahertz Imaging of Breast Cancer using Human and Animal Models
Showing 5 of 14 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
Showing 5 of 11 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Abstract 1943: Elucidating early tumor microenvironmental changes due to immunotherapy with label-free Raman spectroscopy and machine learning
Showing 5 of 9 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Abstract 1943: Elucidating early tumor microenvironmental changes due to immunotherapy with label-free Raman spectroscopy and machine learning
Showing 5 of 9 shared publications
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Optical spectroscopy to monitor tumor response to immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
Showing 5 of 8 shared publications
- Raman spectroscopy reveals phenotype switches in breast cancer metastasis
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Optical spectroscopy to monitor tumor response to immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
Showing 5 of 8 shared publications
- Longitudinal monitoring of tumor response to immune checkpoint inhibitors using noninvasive diffuse reflectance spectroscopy
- Investigating the relationship between hypoxia, hypoxia-inducible factor 1, and the optical redox ratio in response to radiation therapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
Showing 5 of 8 shared publications
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Optical imaging of treatment-naïve human NSCLC reveals changes associated with metastatic recurrence
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Design and Validation of a Multimodal Spatially Offset System Comprising Diffuse Reflectance Spectroscopy and Raman Spectroscopy
- Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications
- Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy
- Investigating Biomarkers of Radiation Resistance in Head and Neck Cancer Using Raman Spectroscopy
- Diffuse reflectance spectroscopy reveals heat stress-induced changes in hemoglobin concentration in chicken breast
- Diffuse Reflectance Spectroscopy of Changes in Tumor Microenvironment in Response to Different Doses of Radiation
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Diffuse reflectance spectroscopy to study the effects of radiation therapy dose on tumor microenvironment
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Supplementary Data from Raman Spectroscopy and Machine Learning Reveals Early Tumor Microenvironmental Changes Induced by Immunotherapy
- Evaluating differences in optical properties of indolent and aggressive murine breast tumors using quantitative diffuse reflectance spectroscopy
- Investigating In Vivo Tumor Biomolecular Changes Following Radiation Therapy Using Raman Spectroscopy
- Design and Validation of a Multimodal Diffuse Reflectance and Spatially Offset Raman Spectroscopy System for In Vivo Applications
- Investigating Tissue Changes Due to Alcohol and Tobacco Consumption Using Optical Spectroscopy
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