Olivia Reyes‐Castro

Researcher

Last publication 2025 Last refreshed 2026-05-02

faculty

3 h-index 43 pubs 36 cited

Research Areas

OverviewAI-generated summary

Olivia Reyes‐Castro's research investigates the cellular and molecular mechanisms underlying skeletal development and age-related bone health. Her recent work utilizes single-cell transcriptomic analysis to identify senescent osteocytes, a type of bone cell, and their role in bone destruction, particularly in the context of breast cancer metastasis. This research explores how these senescent cells trigger pathological processes within the bone microenvironment.

Further investigations examine the influence of metabolic pathways, such as NAD salvage, on skeletal development in mice. Reyes‐Castro also studies the impact of hormonal factors, like estrogens, on bone mass by examining their effects on NAD+ metabolism in osteoclasts, cells responsible for bone resorption. Her work is supported by collaborations with researchers at the University of Arkansas for Medical Sciences, including Aric Anloague and Hayley M. Sabol. Reyes‐Castro has published 43 papers, with an h-index of 3 and 33 total citations.

Metrics

h-index: 3
Publications: 43
Citations: 36

Selected Publications

The Aging Landscape by <scp>scRNAseq</scp> of Mesenchymal Lineage Cells in Mouse Bone (2025)

2 citations DOI OpenAlex
Estrogens protect bone mass by inhibiting NAD <sup>+</sup> metabolism in osteoclasts (2025)

DOI OpenAlex
Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer (2024)

DOI OpenAlex
Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis (2024)

3 citations DOI OpenAlex
The NAD salvage pathway in mesenchymal cells is indispensable for skeletal development in mice (2023)

14 citations DOI OpenAlex