Biography and Research Information
OverviewAI-generated summary
Katy S Papineau's research investigates the toxicological effects of various chemical compounds on liver cells, with a particular focus on drug-induced liver injury. Her work utilizes both in vitro models, such as liver-on-a-chip platforms co-culturing human primary hepatocytes and nonparenchymal liver cells, and studies involving animal models. Papineau has examined the dose-response relationship of specific drugs, including acetaminophen, and industrial chemicals like 6PPD and its transformation product 6PPD-quinone, in primary human hepatocytes. Her publications also explore the impact of certain compounds, such as pexidartinib, on mitochondrial function within liver cells, leading to cell death at clinically relevant concentrations. Additionally, her research extends to the development and application of predictive models for drug toxicity, including a proof-of-concept study on predicting cardiotoxicity using induced pluripotent stem cell-derived cardiomyocytes. Papineau has a h-index of 2 with 5 total publications and 36 citations.
Metrics
- h-index: 2
- Publications: 5
- Citations: 38
Selected Publications
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Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform (2025)
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Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids (2025)
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Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations (2025)
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Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin (2024)
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Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury (2022)
Collaboration Network
Top Collaborators
Lijun Ren
United States Food and Drug Administration
5 shared publications
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Laura K. Schnackenberg
National Center for Toxicological Research
5 shared publications
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Qiang Shi
National Center for Toxicological Research
4 shared publications
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Mark Avigan
Center for Drug Evaluation and Research (US)
2 shared publications
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Lorna Ewart
Emulate (United States) (US)
2 shared publications
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Li Pang
National Center for Toxicological Research
2 shared publications
In database
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
Xi Yang
Center for Drug Evaluation and Research (US)
2 shared publications
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
William B. Mattes
National Center for Toxicological Research
2 shared publications
In database
- Predicting oncology drug-induced cardiotoxicity with donor-specific iPSC-CMs—a proof-of-concept study with doxorubicin
- Pexidartinib impairs liver mitochondrial functions causing cell death in primary human hepatocytes at clinically relevant concentrations
Gonçalo Gamboa da Costa
National Center for Toxicological Research
2 shared publications
In database
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Tucker A. Patterson
United States Food and Drug Administration
2 shared publications
In database
- Toxicity of ubiquitous tire rubber antiozonant N-(1,3-dimethylbutyl)-N′-phenyl-p-phenylenediamine (6PPD) and its transformation product 6PPD-quinone (6PPD-Q) in primary human hepatocytes and liver spheroids
- Challenges and solutions in measuring commonly used biomarkers for drug-induced liver injury in a liver-on-a-chip platform
Ayesha Arefin
National Center for Toxicological Research
1 shared publication
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Dustyn A. Barnette
United States Food and Drug Administration
1 shared publication
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Jessica J. Hawes
United States Food and Drug Administration (US)
1 shared publication
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Donna L. Mendrick
United States Food and Drug Administration
1 shared publication
In database
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
Janey Ronxhi
Emulate (United States) (US)
1 shared publication
- Co‐Culture of Human Primary Hepatocytes and Nonparenchymal Liver Cells in the Emulate® Liver‐Chip for the Study of Drug‐Induced Liver Injury
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