Ricky D. Edmondson
Professor
Also affiliated: United States Food and Drug Administration (2004–2008); University of Michigan (2002); University of Arkansas Medical Center (2009); Mitchell Institute (1998); New Frontier (1998); Abterra Biosciences (United States) (2018); Cancer Research UK Manchester Institute (2009); Winthrop Rockefeller Foundation (2022); Genomic Health (United States) (2002); Texas A&M University (1994–1998)
Faculty Researcher
Biochemistry & Molecular Biology, College of Medicine
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Ricky D. Edmondson's research focuses on understanding molecular mechanisms underlying disease, with recent work investigating phase separation in cancer development, the role of serine protease HTRA1 in membranous nephropathy, and the regulation of bone mass by transferrin receptor 1-mediated iron uptake. He has also explored targeted cancer therapies through the development of PROTAC degraders for NSD3 and dual WDR5 and Ikaros targets. His laboratory group investigates protein interactions and their impact on cellular processes, including the role of TNRC18 in silencing endogenous retrotransposons and the identification of novel antigens in kidney diseases using mass spectrometry.
Edmondson is a Professor in the Department of Biochemistry & Molecular Biology at the University of Arkansas for Medical Sciences. His scholarship metrics include an h-index of 32, with over 91 publications and 4,560 citations. He has collaborated extensively with researchers at his institution, including Samuel G. Mackintosh, Alan J. Tackett, Aaron J. Storey, and Stephanie D. Byrum, with whom he has co-authored multiple publications.
Metrics
- h-index: 32
- Publications: 91
- Citations: 4,606
Selected Publications
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Additional file 2 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 2 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 5 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 5 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 3 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 1 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Additional file 4 of Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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Multiplexed Detection of Membranous Nephropathy Antigens by Multi-Reaction Monitoring Mass Spectrometry (2026)
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Abstract 6079: Resistance-specific proteogenomics in melanoma PDXs (2026)
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Proteomic Profiling of Complement Components in Glomerular Disease (2026)
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Dynamic global acetylation remodeling during the yeast heat shock response (2026)
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277 Proteome turnover dynamics analysis uncovers E3 ligases that enhance T-cell persistence during exhaustion (2025)
Grants & Funding
As listed on this researcher's institutional profile.
- Identification of Druggable Targets to Complement Melanoma Therapy NIH Co-Investigator
- Development of biomarkers for improved classification of proliferative lupus nephritis NIH/Nat. Inst. of Diabetes & Digestive & Kidney Diseases via Arkana Laboratories Co-Investigator
- Role of HELB in the Replication Stress Response Dr. Tacketts COBRA through ACRI NIH/Nat. Inst. of General Medical Sciences via Arkansas Children's Research Institute Co-Investigator
- Biomarkers of Early Renal Functional Decline in Type 2 Diabetes NIH Co-Investigator
- IDeA National Resource for Quantitative Proteomics NIH Co-Investigator
- Development of a Precision Medicine-Based Diagnostic Tool for Membranous Nephropathy NIH/National Institutes of Health via Arkana Laboratories Principal Investigator
- Discovery and Characterization of Novel Sepsis Proteome Biomarkers NIH Co-Investigator
Collaboration Network
Top Collaborators
- Phase separation drives aberrant chromatin looping and cancer development
- Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
Showing 5 of 22 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Transferrin receptor 1-mediated iron uptake regulates bone mass in mice via osteoclast mitochondria and cytoskeleton
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
Showing 5 of 22 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 22 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 17 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 10 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
Showing 5 of 10 shared publications
- Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
- Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
- Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
- Minor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
- Multiplexed Detection of Membranous Antigens by Mass Spectrometry
Showing 5 of 7 shared publications
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
- Phase separation drives aberrant chromatin looping and cancer development
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
Showing 5 of 6 shared publications
- Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
- Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
- Minor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
- Multiplexed Detection of Membranous Antigens by Mass Spectrometry
- Proteomic Profiling of Complement Components in Glomerular Disease
Showing 5 of 6 shared publications
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators
- A conserved BAH module within mammalian BAHD1 connects H3K27me3 to Polycomb gene silencing
- Serine Protease HTRA1 as a Novel Target Antigen in Primary Membranous Nephropathy
- Transforming Growth Factor Beta Receptor 3 (TGFBR3)–Associated Membranous Nephropathy
- Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry
- Minor Antigens in Membranous Nephropathy Identified by Mass Spectrometry
- Proteomic Profiling of Complement Components in Glomerular Disease
- Protective effects of factor XI inhibition by abelacimab in a baboon model of live Staphylococcus aureus sepsis
- Proteogenomics analysis to identify acquired resistance-specific alterations in melanoma PDXs on MAPKi therapy
- Proteogenomics Analysis to Identify Acquired Resistance-Specific Alterations in Melanoma PDXs on MAPKi Therapy
- Anthrax toxins exacerbate sepsis-induced coagulopathy and endothelial dysfunction in a baboon model of anthrax
- Abstract 6079: Resistance-specific proteogenomics in melanoma PDXs
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
- ZMYND11-MBTD1 induces leukemogenesis through hijacking NuA4/TIP60 acetyltransferase complex and a PWWP-mediated chromatin association mechanism
- YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7
- A NSD3-targeted PROTAC suppresses NSD3 and cMyc oncogenic nodes in cancer cells
- TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons
- Cistrome analysis of YY1 uncovers a regulatory axis of YY1:BRD2/4-PFKP during tumorigenesis of advanced prostate cancer
- YY1 relieves p300 autoinhibition to promote histone acetylation in advanced prostate cancer, enhancing the oncogenic signaling of Androgen Receptor Splice Variant 7
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