Aaron J. Storey

High Impact

Researcher

University of Arkansas for Medical Sciences

faculty

22 h-index 132 pubs 1,871 cited

Research Areas

Cancer-related molecular mechanisms research Protein Degradation and Inhibitors Genomics and Chromatin Dynamics Metabolomics and Mass Spectrometry Studies Molecular Biology Techniques and Applications Immune Response and Inflammation Bioinformatics and Genomic Networks

Links

ORCID Lab Website

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OverviewAI-generated summary

Aaron J. Storey's research investigates molecular mechanisms underlying cancer development and disease states. His work includes the study of aberrant chromatin looping driven by phase separation in cancer progression, and the identification of novel therapeutic targets. Storey has explored the use of targeted protein degraders, such as PROTACs, to suppress oncogenic nodes and cancer cell growth. Specific research has focused on developing dual WDR5 and Ikaros PROTAC degraders as anti-cancer agents and investigating NSD3-targeted PROTACs for their effects on cancer cells.

Further investigations by Storey delve into the role of specific proteins in cellular processes relevant to disease. This includes examining how TNRC18 engages with H3K9me3 to mediate the silencing of endogenous retrotransposons. His research also focuses on identifying novel antigens in conditions like primary membranous nephropathy and membranous lupus nephritis using mass spectrometry. Additionally, Storey has analyzed the regulatory axis of YY1:BRD2/4-PFKP during the tumorigenesis of advanced prostate cancer through cistrome analysis.

Storey's scholarly contributions are reflected in his h-index of 22 and over 1,871 citations across 132 publications. He actively collaborates with researchers at the University of Arkansas for Medical Sciences, including Samuel G. Mackintosh, Alan J. Tackett, Sydnye L. Shuttleworth, and Vijay Patel, with whom he has co-authored numerous publications. Storey maintains an active laboratory website to share his research.

Metrics

  • h-index: 22
  • Publications: 132
  • Citations: 1,871

Selected Publications

  • BAHCC1 binds H4K20me1 to facilitate the MCM complex loading and DNA replication (2025) DOI
  • The phenylalanine-and-glycine repeats of NUP98 oncofusions form condensates that selectively partition transcriptional coactivators (2025) DOI
  • Dynamic global acetylation remodeling during the yeast heat shock response (2025) DOI
  • One-pot method for preparing DNA, RNA, and protein for multiomics analysis (2024) DOI
  • TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons (2023) DOI
  • 304 Discovering T cell proteome turnover dynamics to enhance persistence in solid tumors (2023) DOI
  • Characterization of methionine dependence in melanoma cells (2023) DOI
  • Proprotein convertase subtilisin/kexin type 6 (PCSK6) is a likely antigenic target in membranous nephropathy and nonsteroidal anti-inflammatory drug use (2023) DOI
  • Characterization of methionine dependence in melanoma cells (2023) DOI
  • Discovery of seven novel putative antigens in membranous nephropathy and membranous lupus nephritis identified by mass spectrometry (2023) DOI
  • The Alternative Pathway Is Necessary and Sufficient for Complement Activation by Anti-THSD7A Autoantibodies, Which Are Predominantly IgG4 in Membranous Nephropathy (2022) DOI
  • Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic (2022) DOI
  • Cubilin and amnionless protein are novel target antigens in anti–brush border antibody disease (2022) DOI
  • DNA-PKcs kinase activity stabilizes the transcription factor Egr1 in activated immune cells (2021) DOI
  • Phosphoproteomics Provides Novel Insights into the Response of Primary Acute Lymphoblastic Leukemia Cells to Microtubule Depolymerization in G1 Phase of the Cell Cycle (2021) DOI

Collaborators

Researchers in the database who share publications

Samuel G. Mackintosh University of Arkansas for Medical Sciences 19 shared publications Alan J. Tackett University of Arkansas for Medical Sciences 16 shared publications Sydnye L. Shuttleworth University of Arkansas for Medical Sciences 16 shared publications Vijay Patel University of Arkansas for Medical Sciences 15 shared publications Donghoon Yoon University of Arkansas for Medical Sciences 15 shared publications Ginell R. Post University of Arkansas for Medical Sciences 15 shared publications Samantha Kendrick University of Arkansas for Medical Sciences 15 shared publications Brendan Frett University of Arkansas for Medical Sciences 15 shared publications

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Samuel G. Mackintosh University of Arkansas for Medical Sciences
Cancer-related molecular mechanisms research Protein Degradation and Inhibitors Genomics and Chromatin Dynamics
Good match 4 shared topics