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Listed
Presence
Current · Arkansas
Last published
2024
Sources
OpenAlex · ORCID
Refreshed
2026-08-20
R
Robert Griffin
Federal Grant PI
High Impact
Professor
Also affiliated: Marquette University (2013); University of the Sciences (1992–1998); University of Vermont (1976–1997); Hospital for Special Surgery (2017–2023); National Institutes of Health (1998); Environmental Protection Agency (1974); Research Triangle Park Foundation (1974–2009); Arthur D. Little (United States) (1996); University of New Hampshire (2003–2006); Aston University (1988–1996); Duke University (2003); University of California, Irvine (1998); Cornell University (2022); Oklahoma City University (2005); Mitchell Institute (2007); Government of the United Kingdom (1981); Centre for Nursing Innovation (2016); National Institute of Environmental Health Sciences (1993–1998); GlaxoSmithKline (United States) (2004–2009); Winthrop Rockefeller Foundation (2024); American College of Clinical Pharmacy (1982); UCB Pharma (United Kingdom) (2013–2020); Takeda (United States) (2015–2024); Irvine University (1998); Millennium Engineering and Integration (United States) (2023); GlaxoSmithKline (Netherlands) (2001); Environmental Protection Agency (1974); Takeda (Japan) (2015–2021); Rice University (2015–2024); Roger Williams University (2023); Newcastle University (1994–2014); Texas A&M University (2007); Philadelphia University (1992)
Faculty Researcher
Radiation Oncology, College of Medicine
34 h-index
283 pubs
4,798 cited
Research Areas
Biomedical Subjects
Biography and Research Information
OverviewAI-generated summary
Robert Griffin's research focuses on the development of novel therapeutic agents and strategies for cancer treatment. His work investigates the molecular mechanisms underlying cancer and explores targeted therapies, including inhibitors of specific cellular pathways and immunotherapies. Griffin has published research on the targeted inhibitor mobocertinib for EGFR exon 20 insertion mutants in non-small cell lung cancer, and on novel carbocyclic pyrimidine cyclic dinucleotide STING agonists for antitumor immunotherapy.
His research also extends to the design of proteasome inhibitors with efficacy against parasitic infections and selectivity for the target proteasome. Griffin's work has been supported by federal grants, including funding from the NIH/National Cancer Institute for the Cancer and Developing Entrepreneurial Technologies (CADET) project. He maintains an active research group and collaborates with colleagues at the University of Arkansas for Medical Sciences, including Samir V. Jenkins, Azemat Jamshidi‐Parsian, Ruud P.M. Dings, and Alan J. Tackett.
With a career marked by significant scholarly output, Griffin has an h-index of 34 and has authored over 280 publications. His recent work also includes studies on the role of microRNAs in viral infections and the design of membrane-traversing macrocycles. He is recognized as a highly cited researcher.
Metrics
- h-index: 34
- Publications: 283
- Citations: 4,798
Selected Publications
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The future is not always uniform: rethinking radiotherapy through spatial fractionation (2026)
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Abstract 4785: Thermal regulation of dysbiotic tumor vasculature (2026)
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Abstract 7625: Development of a blood-based tumor hypoxia detection assay (2026)
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Modified tumor uptake and biodistribution of nanoparticles coated with small extracellular vesicle membranes derived from distinct tumor cell lines (2026)
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Pancreatic cancer extracellular vesicles stimulate Schwann cell activation and perineural invasion in vitro via IL-8/CCL2 (2025)
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Abstract B026: Pancreatic tumor extracellular vesicles induce perineural invasion in vitro via IL- 8/CCL2 (2024)
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The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made (2024)
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Interrogating the Role of Endocytosis Pathway and Organelle Trafficking for Doxorubicin-Based Combination Ionic Nanomedicines (2024)
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Innovations in Physics, Biology and Clinical Translation of Spatially Fractionated and FLASH Radiotherapy (2024)
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Bystander Effects in Spatially Fractionated Radiation Therapy: From Molecule To Organism To Clinical Implications (2024)
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Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer (2024)
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Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials (2023)
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Cationic Porphyrin-Based Ionic Nanomedicines for Improved Photodynamic Therapy (2023)
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Morphological Effects and In Vitro Biological Mechanisms of Radiation-Induced Cell Killing by Gold Nanomaterials (2023)
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Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells (2023)
Federal Grants 1 $270,624 total
NIH
Contact PI
Sep 2025 - Aug 2030
Grants & Funding
As listed on this researcher's institutional profile. Federal awards with verified records are shown above.
- Detection of hypoxia markers in tumor exosomes using Raman spectroscopy University of Arkansas at Fayetteville Principal Investigator
- Functional optical biomarkers of response to therapy in head and neck squamous cell carcinoma- Resubmission Arkansas Economic Development Commission via National Science Foundation Principal Investigator
- Improvement of cellular immunotherapy during dysbiosis NIH/Nat. Cancer Institute Principal Investigator
- RII Track-1: Arkansas ASSET Initiative III - Continuation Y5 - Continuation National Science Foundation via Arkansas Economic Development Commission Principal Investigator
- Physiological Factors in Hyperthermia NIH Principal Investigator
- Determination of functional and molecular biomarkers of treatment resistance with multimodal optical spectroscopy- Resubmission NIH/Nat. Cancer Institute via University of Arkansas at Fayetteville Co-Investigator
- Preventing immune system dysregulation during deep-space missions by Tocofexol, a modified isomer of vitamin E - AA request National Aeronautics & Space Administration via Arkansas Space Grant Consortium Principal Investigator
- CASE Year 5 support for Dr. Jamshidi-Parsian Arkansas Economic Development Commission Principal Investigator
- Targeting solid-tumor vasculature with co-encapsulated arsenic- and platinum-based nanobins NIH/Nat. Cancer Institute via University of Kentucky Research Foundation Principal Investigator
- EPSCoR - CASE Summer National Science Foundation via Arkansas Economic Development Commission Principal Investigator
- Studies of Endothelial Dysfunction under Simulated Space Environment National Aeronautics & Space Administration via Arkansas Space Grant Consortium Co-Principal Investigator
- Photoswitchable nanoprobes for in vivo flow cytometry NIH Co-Investigator
- Improvement of cellular immunotherapy during dysbiosis- Resubmission NIH Co-Investigator
- Investigating the role of metabolic rewiring in breast tumor innervation NIH/Nat. Cancer Institute via University of Arkansas at Fayetteville Principal Investigator
- Advancing Breast Cancer Treatment through Suppression of Chemo-Resistance UAMS Executive Breast Committee Principal Investigator
- Center for Studies of Host Response to Cancer Therapy NIH Co-Investigator
- Study of anti-angiogenesis enhanced radiotherapy NIH Principal Investigator
Collaboration Network
Top Collaborators
Samir V. Jenkins
University of Arkansas for Medical Sciences
14 shared publications
In database
- Enhanced photothermal heating and combination therapy of NIR dye <i>via</i> conversion to self-assembled ionic nanomaterials
- Photothermal Response Induced by Nanocage-Coated Artificial Extracellular Matrix Promotes Neural Stem Cell Differentiation
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- Bystander Effects in Spatially Fractionated Radiation Therapy: From Molecule To Organism To Clinical Implications
- Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy
Showing 5 of 14 shared publications
Azemat Jamshidi‐Parsian
University of Arkansas for Medical Sciences
10 shared publications
In database
- Photothermal Response Induced by Nanocage-Coated Artificial Extracellular Matrix Promotes Neural Stem Cell Differentiation
- Exosomal MicroRNA and Protein Profiles of Hepatitis B Virus-Related Hepatocellular Carcinoma Cells
- Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy
- Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy
- Pancreatic Tumor-Derived Extracellular Vesicles Stimulate Schwann Cell Phenotype Indicative of Perineural Invasion via IL-8 Signaling
Showing 5 of 10 shared publications
Alan J. Tackett
University of Arkansas for Medical Sciences
5 shared publications
In database
- MSC exosome-mediated cardioprotection in ischemic mouse heart comparative proteomics of infarct and peri-infarct areas
- Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors
- Author Correction: Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes
- Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
Michael J. Borrelli
University of Arkansas for Medical Sciences (US)
5 shared publications
- Photothermal Response Induced by Nanocage-Coated Artificial Extracellular Matrix Promotes Neural Stem Cell Differentiation
- Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy
- Nanoscale investigation and control of photothermal action of gold nanostructure-coated surfaces
- Liposome Formulation for Tumor-Targeted Drug Delivery Using Radiation Therapy
- Morphological Effects and In Vitro Biological Mechanisms of Radiation-Induced Cell Killing by Gold Nanomaterials
Nawab Ali
University of Arkansas at Little Rock
5 shared publications
In database
- Enhanced photothermal heating and combination therapy of NIR dye <i>via</i> conversion to self-assembled ionic nanomaterials
- Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer
- Cationic Porphyrin-Based Ionic Nanomedicines for Improved Photodynamic Therapy
- Identification and functional characterization of multiple inositol polyphosphate phosphatase1 (Minpp1) isoform-2 in exosomes with potential to modulate tumor microenvironment
- Interrogating the Role of Endocytosis Pathway and Organelle Trafficking for Doxorubicin-Based Combination Ionic Nanomedicines
Rajshekhar A. Kore
Central Arkansas Veterans Healthcare System
4 shared publications
In database
- MSC exosome-mediated cardioprotection in ischemic mouse heart comparative proteomics of infarct and peri-infarct areas
- Author Correction: Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes
- Proteomic Analysis of Transcription Factors Involved in the Alteration of Ischemic Mouse Heart as Modulated by MSC Exosomes
- Proteomic analysis of transcription factors involved in the alteration of ischemic mouse heart as modulated by MSC exosomes
Ruud P.M. Dings
University of Arkansas for Medical Sciences
4 shared publications
In database
- Bystander Effects in Spatially Fractionated Radiation Therapy: From Molecule To Organism To Clinical Implications
- Nanoscale investigation and control of photothermal action of gold nanostructure-coated surfaces
- Dysbiotic stress increases the sensitivity of the tumor vasculature to radiotherapy and c-Met inhibitors
- Morphological Effects and In Vitro Biological Mechanisms of Radiation-Induced Cell Killing by Gold Nanomaterials
Rabab N. Hamzah
University of Arkansas at Little Rock
4 shared publications
In database
- Exosome Traceability and Cell Source Dependence on Composition and Cell-Cell Cross Talk
- Nanoparticle-Labeled Exosomes as Theranostic Agents: A Review
- Identification and functional characterization of multiple inositol polyphosphate phosphatase1 (Minpp1) isoform-2 in exosomes with potential to modulate tumor microenvironment
- Author Correction: Molecular events in MSC exosome mediated cytoprotection in cardiomyocytes
Noureen Siraj
University of Arkansas at Little Rock
4 shared publications
In database
- Enhanced photothermal heating and combination therapy of NIR dye <i>via</i> conversion to self-assembled ionic nanomaterials
- Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer
- Cationic Porphyrin-Based Ionic Nanomedicines for Improved Photodynamic Therapy
- Interrogating the Role of Endocytosis Pathway and Organelle Trafficking for Doxorubicin-Based Combination Ionic Nanomedicines
J.W. Snider
4 shared publications
- Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials
- Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey
- An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer
- The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made
Hualin Zhang
University of Southern California (US)
4 shared publications
- Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials
- Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey
- An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer
- The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made
Nina A. Mayr
University of Maryland, Baltimore (US)
4 shared publications
- Overview and Recommendations for Prospective Multi-institutional Spatially Fractionated Radiation Therapy Clinical Trials
- Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey
- An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer
- The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made
Seung-Hyun Jung
St. Jude Children's Research Hospital (US)
3 shared publications
- Photothermal Response Induced by Nanocage-Coated Artificial Extracellular Matrix Promotes Neural Stem Cell Differentiation
- Nanoscale investigation and control of photothermal action of gold nanostructure-coated surfaces
- Morphological Effects and In Vitro Biological Mechanisms of Radiation-Induced Cell Killing by Gold Nanomaterials
Samantha Macchi
University of Arkansas at Little Rock (US)
3 shared publications
- Enhanced photothermal heating and combination therapy of NIR dye <i>via</i> conversion to self-assembled ionic nanomaterials
- Doxorubicin-Based Ionic Nanomedicines for Combined Chemo-Phototherapy of Cancer
- Cationic Porphyrin-Based Ionic Nanomedicines for Improved Photodynamic Therapy
Beatriz E. Amendola
3 shared publications
- Practice Patterns of Spatially Fractionated Radiation Therapy: A Clinical Practice Survey
- An International Consensus on the Design of Prospective Clinical–Translational Trials in Spatially Fractionated Radiation Therapy for Advanced Gynecologic Cancer
- The Radiosurgery Society Working Groups on GRID, LATTICE, Microbeam, and FLASH Radiotherapies: Advancements Symposium and Subsequent Progress Made
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