R
Randall R Rainwater
MD/PhD student
grad_student
3 h-index
14 pubs
43 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Randall R Rainwater's research focuses on molecular mechanisms underlying cellular responses and disease processes. He has investigated the role of DNA-activated protein kinase catalytic subunit (DNA-PKcs) in T cell activation and cytotoxicity, as well as its novel regulation of LAT-mediated T cell signaling. His work includes the discovery of DA-143, a DNA-PKcs inhibitor with improved solubility. Rainwater has also examined cellular injury caused by sevelamer crystals in the gastrointestinal mucosa and explored the susceptibility of acute lymphoblastic leukemia cells to microtubule depolymerization. His publications also touch upon plant-microbe symbiosis and EphA2 intracellular region signaling. Rainwater's research network includes collaborators from the University of Arkansas for Medical Sciences, with whom he has co-authored multiple publications.
Metrics
- h-index: 3
- Publications: 14
- Citations: 43
Selected Publications
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Promising Clinical Outcomes Using Rotational Achilles Autograft for Knee Arthroplasty Terrible Triad (2026)
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Postoperative complications following total shoulder arthroplasty in multiple myeloma patients with prior bone marrow transplantation (2026)
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The Impact of Bone Marrow Transplant on Total Joint Arthroplasty Outcomes in Patients Diagnosed With Multiple Myeloma (2025)
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A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids (2025)
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DNA-PKcs Controls the Cytotoxic T-Cell Response to Cancer and Transplant Allograft Through Regulating LAT-Dependent Signaling (2025)
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DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells (2025)
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Gastrointestinal Mucosal Cell Injury Caused by Sevelamer Crystals: Case Series and Literature Review (2025)
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Pregnancy, Peritoneal Dialysis, and a Dive into Some Unchartered Territories (2024)
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Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441 (2024)
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Microstructure of the radial head: Insights into anatomical variations and implications for advanced interventions (2024)
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Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells (2023)
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Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways (2022)
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The legume-rhizobia symbiosis can be supported on Mars soil simulants (2021)
Collaboration Network
Top Collaborators
Lyle Burdine
Arkansas Children's Hospital (US)
6 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids
- DNA-PKcs phosphorylates LAT impacting its localization to the immune synapse and downstream signaling in CD4+ and CD8+ T cells 2409
Showing 5 of 6 shared publications
Zachary J. Waldrip
Arkansas Children's Hospital (US)
6 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids
- DNA-PKcs phosphorylates LAT impacting its localization to the immune synapse and downstream signaling in CD4+ and CD8+ T cells 2409
Showing 5 of 6 shared publications
Marie Burdine
Arkansas Children's Hospital (US)
6 shared publications
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- A functional surface display system in Saccharomyces boulardii for protein absorption in simulated intestinal fluids
- DNA-PKcs phosphorylates LAT impacting its localization to the immune synapse and downstream signaling in CD4+ and CD8+ T cells 2409
Showing 5 of 6 shared publications
Ana Clara P. Azevedo‐Pouly
Arkansas Children's Hospital
5 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- Discovery of the DNA-PKcs inhibitor DA-143 which exhibits enhanced solubility relative to NU7441
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- DNA-PKcs phosphorylates LAT impacting its localization to the immune synapse and downstream signaling in CD4+ and CD8+ T cells 2409
- Novel regulation of LAT-mediated T cell signaling by DNA-PKcs 2613
Brian Koss
University of Arkansas for Medical Sciences
2 shared publications
In database
- Chemical inhibition of <scp>DNA‐PKcs</scp> impairs the activation and cytotoxicity of <scp>CD4</scp><sup>+</sup> helper and <scp>CD8</scp><sup>+</sup> effector T cells
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
Nicholas A. Callais
Arkansas Children's Hospital (US)
2 shared publications
- DNA-PKcs governs LAT-dependent signaling in CD4 <sup>+</sup> and CD8 <sup>+</sup> T cells
- Novel regulation of LAT-mediated T cell signaling by DNA-PKcs 2613
Magdalena Delgado
University of Arkansas for Medical Sciences (US)
1 shared publication
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Billie Heflin
University of Arkansas for Medical Sciences
1 shared publication
In database
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Alicja Urbaniak
University of Arkansas for Medical Sciences
1 shared publication
In database
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Kaitlynn Butler
University of Arkansas for Medical Sciences
1 shared publication
In database
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Mari K. Davidson
University of Arkansas for Medical Sciences (US)
1 shared publication
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Reine U. Protacio
University of Arkansas for Medical Sciences
1 shared publication
In database
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Giulia Baldini
University of Arkansas for Medical Sciences
1 shared publication
In database
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Andrea Edwards
University of Arkansas for Medical Sciences (US)
1 shared publication
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Megan R. Reed
University of Arkansas for Medical Sciences
1 shared publication
In database
- Primary acute lymphoblastic leukemia cells are susceptible to microtubule depolymerization in G1 and M phases through distinct cell death pathways
Similar Researchers
Based on overlapping research topics
Ana Clara P. Azevedo‐Pouly
University of Arkansas for Medical Sciences
Immune Cell Function and Interaction
DNA Repair Mechanisms
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National Center for Toxicological Research
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Kayla Hefner
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
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Taylor McElory
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
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Gut microbiota and health
Michelle Robeson
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Pharmacological Effects and Toxicity Studies
Gut microbiota and health
Azure L. Yarbrough
University of Arkansas for Medical Sciences
Cancer Treatment and Pharmacology
Pharmacological Effects and Toxicity Studies
Receptor Mechanisms and Signaling