Biography and Research Information
OverviewAI-generated summary
Shiv Srivastava's research focuses on understanding the genetic and molecular underpinnings of prostate cancer, with a particular emphasis on identifying susceptibility variants and developing targeted therapies. Recent work has investigated novel susceptibility variants for prostate cancer and developed a multiancestry polygenic risk score associated with aggressive disease in men of African ancestry. Srivastava has also examined the prognostic features of biochemical recurrence of prostate cancer following radical prostatectomy, utilizing multiparametric MRI and immunohistochemistry analysis of biopsy specimens. Further research has explored the germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer, identifying potentially targetable RAD genes. The researcher has also developed new selective inhibitors of ERG-positive prostate cancer.
Additional areas of investigation include the clinical utility of serum biomarker panels for distinguishing prostate cancer from benign prostatic hyperplasia. Srivastava's work also extends to fundamental biological processes, such as the inhibition of BAK-mediated apoptosis by the BH3-only protein BNIP5 and the structural basis of BAK sequestration by MCL-1 in apoptosis.
Srivastava holds a distinguished record with an h-index of 64, over 490 publications, and more than 15,000 citations, recognizing their significant contributions to the field. Key collaborators include Steve Lee and Elisabeth Ferreira from the University of Arkansas for Medical Sciences, and Bin Dong and Meek Yang from the University of Arkansas at Fayetteville.
Metrics
- h-index: 64
- Publications: 490
- Citations: 15,057
Selected Publications
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Structural basis of BAK sequestration by MCL-1 in apoptosis (2025)
Collaboration Network
Top Collaborators
György Petrovics
Henry M. Jackson Foundation (US)
38 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
- Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men
- Subclonal <i>CHD1</i> deletion is more frequent in African American prostate cancers and associated with rapid disease progression and limited levels of homologous recombination deficiency
Showing 5 of 38 shared publications
David G. McLeod
Uniformed Services University of the Health Sciences (US)
30 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Age and Tumor Differentiation-Associated Gene Expression Based Analysis of Non-Familial Prostate Cancers
- Filamin A Is a Prognostic Serum Biomarker for Differentiating Benign Prostatic Hyperplasia from Prostate Cancer in Caucasian and African American Men
- Study about Predominance of ERG-Negative High-Grade Prostate Cancers in African American Men
- Data from Evaluation of the 8q24 Prostate Cancer Risk Locus and <i>MYC</i> Expression
Showing 5 of 30 shared publications
Lakshmi Ravindranath
Henry M. Jackson Foundation (US)
28 shared publications
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men
- Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men
- Abstract 2074: Germline mutation landscape of all DNA repair genes in African American prostate cancer patients
- PD65-12 GERMLINE MUTATION LANDSCAPE OF DNA REPAIR GENES IN AFRICAN AMERICAN PROSTATE CANCER PATIENTS HIGHLIGHT POTENTIALLY TARGETABLE <i>RAD</i> GENES
Showing 5 of 28 shared publications
Yongmei Chen
Henry M. Jackson Foundation (US)
22 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
- Subclonal <i>CHD1</i> deletion is more frequent in African American prostate cancers and associated with rapid disease progression and limited levels of homologous recombination deficiency
- Abstract 2074: Germline mutation landscape of all DNA repair genes in African American prostate cancer patients
Showing 5 of 22 shared publications
Albert Dobi
Henry M. Jackson Foundation (US)
21 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Prognostic Features of Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy Based on Multiparametric MRI and Immunohistochemistry Analysis of MRI-guided Biopsy Specimens
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- New Selective Inhibitors of ERG Positive Prostate Cancer: ERGi-USU-6 Salt Derivatives
- Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia
Showing 5 of 21 shared publications
Inger L. Rosner
20 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Prognostic Features of Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy Based on Multiparametric MRI and Immunohistochemistry Analysis of MRI-guided Biopsy Specimens
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Clinical utility of a serum biomarker panel in distinguishing prostate cancer from benign prostate hyperplasia
- Abstract 2074: Germline mutation landscape of all DNA repair genes in African American prostate cancer patients
Showing 5 of 20 shared publications
Isabell A. Sesterhenn
18 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Prognostic Features of Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy Based on Multiparametric MRI and Immunohistochemistry Analysis of MRI-guided Biopsy Specimens
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Age and Tumor Differentiation-Associated Gene Expression Based Analysis of Non-Familial Prostate Cancers
- Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression
Showing 5 of 18 shared publications
Shyh‐Han Tan
Uniformed Services University of the Health Sciences (US)
17 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Development and characterization of an ETV1 rabbit monoclonal antibody for the immunohistochemical detection of ETV1 expression in cancer tissue specimens
- Abstract 2074: Germline mutation landscape of all DNA repair genes in African American prostate cancer patients
- PD65-12 GERMLINE MUTATION LANDSCAPE OF DNA REPAIR GENES IN AFRICAN AMERICAN PROSTATE CANCER PATIENTS HIGHLIGHT POTENTIALLY TARGETABLE <i>RAD</i> GENES
Showing 5 of 17 shared publications
Taduru Sreenath
16 shared publications
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Figures S1-S5 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Showing 5 of 16 shared publications
Albert Dobi
16 shared publications
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Figures S1-S5 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Showing 5 of 16 shared publications
Gauthaman Sukumar
13 shared publications
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Abstract 2074: Germline mutation landscape of all DNA repair genes in African American prostate cancer patients
- PD65-12 GERMLINE MUTATION LANDSCAPE OF DNA REPAIR GENES IN AFRICAN AMERICAN PROSTATE CANCER PATIENTS HIGHLIGHT POTENTIALLY TARGETABLE <i>RAD</i> GENES
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Showing 5 of 13 shared publications
Clifton L. Dalgard
13 shared publications
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Abstract 2074: Germline mutation landscape of all DNA repair genes in African American prostate cancer patients
- PD65-12 GERMLINE MUTATION LANDSCAPE OF DNA REPAIR GENES IN AFRICAN AMERICAN PROSTATE CANCER PATIENTS HIGHLIGHT POTENTIALLY TARGETABLE <i>RAD</i> GENES
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Showing 5 of 13 shared publications
Charles P. Xavier
12 shared publications
- New Selective Inhibitors of ERG Positive Prostate Cancer: ERGi-USU-6 Salt Derivatives
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Tables S1 and S2 from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Data from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
- Supplementary Materials and Methods and References from Identification of a Small Molecule That Selectively Inhibits ERG-Positive Cancer Cell Growth
Showing 5 of 12 shared publications
Bungo Furusato
12 shared publications
- Supplementary Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer
- Data from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
- Data from Delineation of <i>TMPRSS2-ERG</i> Splice Variants in Prostate Cancer
- Data from Higher Expression of the Androgen-Regulated Gene <i>PSA/HK3</i> mRNA in Prostate Cancer Tissues Predicts Biochemical Recurrence-Free Survival
- Data from Prostate Cancer Risk Allele Specific for African Descent Associates with Pathologic Stage at Prostatectomy
Showing 5 of 12 shared publications
Jennifer Cullen
Uniformed Services University of the Health Sciences (US)
11 shared publications
- Focal p53 protein expression and lymphovascular invasion in primary prostate tumors predict metastatic progression
- Prognostic Features of Biochemical Recurrence of Prostate Cancer Following Radical Prostatectomy Based on Multiparametric MRI and Immunohistochemistry Analysis of MRI-guided Biopsy Specimens
- Germline mutation landscape of DNA damage repair genes in African Americans with prostate cancer highlights potentially targetable RAD genes
- Age and Tumor Differentiation-Associated Gene Expression Based Analysis of Non-Familial Prostate Cancers
- Association of TP53 Single Nucleotide Polymorphisms with Prostate Cancer in a Racially Diverse Cohort of Men
Showing 5 of 11 shared publications
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