T
Timothy J. Muldoon Data-verified
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
Federal Grant PI
Associate Professor
faculty
17 h-index
95 pubs
1,344 cited
Research Areas
Links
Biography and Research Information
OverviewAI-generated summary
Timothy J. Muldoon's research focuses on biomedical optics and imaging, with a particular emphasis on cancer research and immunotherapy. He has received significant funding from the National Science Foundation (NSF) for an REU site focused on training in emerging biomedical optics and imaging approaches, totaling $414,426.
His work investigates the application of advanced imaging techniques to understand tumor microenvironments and treatment responses. Recent publications explore autofluorescence imaging of metabolic cofactors in macrophages, the role of macrophage-targeted immunotherapy in enhancing tumor sensitivity to chemotherapy in murine colon carcinoma models, and the spatial characterization of multicellular tumor spheroids. Muldoon also examines longitudinal markers of perfusion and angiogenesis in colorectal tumors to differentiate treatment strategies and investigates the physiological and therapeutic role of CD47 in macrophage function and cancer.
Muldoon's research extends to statistical methods for analyzing longitudinal biomedical data, including the development and application of generalized additive models. He has a history of collaboration with researchers at the University of Arkansas at Fayetteville, including Shelby N. Bess, Mostafa Elsaadany, Matthew J. Igoe, and Christopher E. Nelson. His scholarly output is characterized by a h-index of 16, with over 93 publications and 1,328 citations.
Metrics
- h-index: 17
- Publications: 95
- Citations: 1,344
Selected Publications
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Metabolic Imaging and Characterization of Multicomponent Spheroid Models in Vitro. (2025)
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BOARD # 307: University of Arkansas Biomedical Engineering REU Site: Training in Emerging Biomedical Optics and Imaging Approaches (2025)
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BOARD # 16: Equipping Biomedical Engineering Students with User-Centered Design Skills: Insights from a Clinical Immersion Course (2025)
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Advancing Equity in Biomedical Engineering Education: Insights from Clinical Observations and Needs-Finding Courses (2025)
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A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct (2025)
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Quantifying treatment response to a macrophage-targeted therapy in combination with immune checkpoint inhibitors after exposure to conventional chemotherapy (2025)
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The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer (2024)
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Development of an Innovation Corps-Modelled Bioengineering Course to Promote Entrepreneurial Engagement Among Undergraduate Students (2024)
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Toward Equity and Inclusivity in Engineering Classrooms: Understanding Students' Disparities in Response to Clinical Observations and Needs-Finding Course Development (2024)
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Assessment and Impact of a Clinical Observations and Needs Finding Course on Biomedical Engineering Education Outcomes (2024)
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Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles (2024)
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Abstract 5549: Multicellular spheroid structural and metabolic characterization through radial line profiling (2024)
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Board 107: Work in Progress: Development of an Innovation Corps-Modeled Bioengineering Course to Promote Entrepreneurial Engagement among Undergraduate Students. (2024)
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Board 12: Work in progress: Assessment and impact of a Clinical Observations and Needs Finding service-learning course on Biomedical Engineering outcomes (2024)
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<i>In vivo</i> measurement of NADH fluorescence lifetime in skeletal muscle via fiber-coupled time-correlated single photon counting (2023)
Federal Grants 1 $414,426 total
NSF
PI
May 2023 - Apr 2027
REU Site: Training in Emerging Biomedical Optics and Imaging Approaches
Collaboration Network
Top Collaborators
Shelby N. Bess
University of Arkansas at Fayetteville
13 shared publications
In database
- Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages
- Macrophage-targeted anti-CCL2 immunotherapy enhances tumor sensitivity to 5-fluorouracil in a Balb/c-CT26 murine colon carcinoma model measured using diffuse reflectance spectroscopy
- Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles
- The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer
- Live-Cell Imaging Quantifies Changes in Function and Metabolic NADH Autofluorescence During Macrophage-Mediated Phagocytosis of Tumor Cells
Showing 5 of 13 shared publications
Ariel I. Mundo
University of Arkansas at Fayetteville (US)
8 shared publications
- Generalized additive models to analyze nonlinear trends in biomedical longitudinal data using R: Beyond repeated measures ANOVA and linear mixed models
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- Generalized additive models to analyze non-linear trends in biomedical longitudinal data using R: Beyond repeated measures ANOVA and Linear Mixed Models
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- Minimally invasive in vivo endoscopic monitoring of dextran sulfate sodium-induced murine colitis
Showing 5 of 8 shared publications
Mostafa Elsaadany
University of Arkansas at Fayetteville
8 shared publications
In database
- Employing Faculty, Peer Mentoring and Coaching to Increase the Self-Confidence and Belongingness of First-Generation College Students in Biomedical Engineering
- Board 12: Work in progress: Assessment and impact of a Clinical Observations and Needs Finding service-learning course on Biomedical Engineering outcomes
- Board 107: Work in Progress: Development of an Innovation Corps-Modeled Bioengineering Course to Promote Entrepreneurial Engagement among Undergraduate Students.
- Assessment and Impact of a Clinical Observations and Needs Finding Course on Biomedical Engineering Education Outcomes
- Toward Equity and Inclusivity in Engineering Classrooms: Understanding Students' Disparities in Response to Clinical Observations and Needs-Finding Course Development
Showing 5 of 8 shared publications
Matthew J. Igoe
University of Arkansas at Fayetteville
5 shared publications
In database
- Autofluorescence imaging of endogenous metabolic cofactors in response to cytokine stimulation of classically activated macrophages
- Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles
- The Physiological and Therapeutic Role of CD47 in Macrophage Function and Cancer
- Live-Cell Imaging Quantifies Changes in Function and Metabolic NADH Autofluorescence During Macrophage-Mediated Phagocytosis of Tumor Cells
- Abstract 5549: Multicellular spheroid structural and metabolic characterization through radial line profiling
Christopher E. Nelson
University of Arkansas at Fayetteville
4 shared publications
In database
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- A Dual-Fluorescence Assay for Gene Delivery Vehicle Screening in Macrophages with an Inflammation-Inducible Reporter Construct
- A dual-fluorescence assay for gene delivery vehicle screening in macrophages with an inflammation-inducible reporter construct
Jacquelynn Horsey
University of Arkansas for Medical Sciences
4 shared publications
In database
- Board 12: Work in progress: Assessment and impact of a Clinical Observations and Needs Finding service-learning course on Biomedical Engineering outcomes
- Assessment and Impact of a Clinical Observations and Needs Finding Course on Biomedical Engineering Education Outcomes
- Toward Equity and Inclusivity in Engineering Classrooms: Understanding Students' Disparities in Response to Clinical Observations and Needs-Finding Course Development
- Advancing Equity in Biomedical Engineering Education: Insights from Clinical Observations and Needs-Finding Courses
Abdussaboor Muhammad
University of Arkansas at Fayetteville
3 shared publications
In database
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- Optical and molecular longitudinal tracking of primary colorectal murine tumors shows differences in the angiogenic response to maximum-tolerated and metronomic approaches
Gaven K. Smart
University of Arkansas at Fayetteville
3 shared publications
In database
- Scaffold-free development of multicellular tumor spheroids with spatial characterization of structure and metabolic radial profiles
- Abstract 5549: Multicellular spheroid structural and metabolic characterization through radial line profiling
- Quantifying treatment response to a macrophage-targeted therapy in combination with immune checkpoint inhibitors after exposure to conventional chemotherapy
Thomas McGehee
University of Arkansas at Fayetteville
3 shared publications
In database
- Assessment and Impact of a Clinical Observations and Needs Finding Course on Biomedical Engineering Education Outcomes
- Development of an Innovation Corps-Modelled Bioengineering Course to Promote Entrepreneurial Engagement Among Undergraduate Students
- Advancing Equity in Biomedical Engineering Education: Insights from Clinical Observations and Needs-Finding Courses
John Tipton
University of Arkansas at Fayetteville (US)
2 shared publications
- Generalized additive models to analyze nonlinear trends in biomedical longitudinal data using R: Beyond repeated measures ANOVA and linear mixed models
- Generalized additive models to analyze non-linear trends in biomedical longitudinal data using R: Beyond repeated measures ANOVA and Linear Mixed Models
Elizabeth A. Bullard
University of Arkansas at Fayetteville (US)
2 shared publications
- Minimally invasive in vivo endoscopic monitoring of dextran sulfate sodium-induced murine colitis
- In Vivo Endoscopic Imaging and Diffuse Reflectance Spectroscopy in Dextran Sulfate Sodiuminduced Murine Colitis v1
Kerlin Balza
University of Arkansas at Fayetteville
2 shared publications
In database
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
- Longitudinal examination of perfusion and angiogenesis markers in primary colorectal tumors shows distinct signatures for metronomic and maximum-tolerated dose strategies
Kathryn Miller Priest
University of Arkansas at Fayetteville
2 shared publications
In database
- <i>In vivo</i> measurement of NADH fluorescence lifetime in skeletal muscle via fiber-coupled time-correlated single photon counting
- Minimally invasive in vivo endoscopic monitoring of dextran sulfate sodium-induced murine colitis
Jeffrey C. Wolchok
University of Arkansas at Fayetteville
2 shared publications
In database
- <i>In vivo</i> measurement of NADH fluorescence lifetime in skeletal muscle via fiber-coupled time-correlated single photon counting
- BOARD # 307: University of Arkansas Biomedical Engineering REU Site: Training in Emerging Biomedical Optics and Imaging Approaches
Amanda Walls
University of Arkansas at Fayetteville
2 shared publications
In database
- Board 107: Work in Progress: Development of an Innovation Corps-Modeled Bioengineering Course to Promote Entrepreneurial Engagement among Undergraduate Students.
- Development of an Innovation Corps-Modelled Bioengineering Course to Promote Entrepreneurial Engagement Among Undergraduate Students
Similar Researchers
Based on overlapping research topics
Shelby N. Bess
University of Arkansas at Fayetteville
Medical Imaging Techniques and Applications
Cancer Immunotherapy and Biomarkers
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Gaven K. Smart
University of Arkansas at Fayetteville
Medical Imaging Techniques and Applications
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Brian Russ
University of Arkansas for Medical Sciences
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Cancer Immunotherapy and Biomarkers
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Abigale Clark
University of Arkansas for Medical Sciences
Immune Response and Inflammation
Cancer Treatment and Pharmacology
Metabolism and Genetic Disorders
Nishanth Thalambadu
University of Arkansas for Medical Sciences
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Cancer Treatment and Pharmacology
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Farah Mazahvreh
University of Arkansas for Medical Sciences
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Cancer Treatment and Pharmacology
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