Hui‐Ming Chang

Federal Grant PI High Impact

Professor

UAMS

Last publication 2025 Last refreshed 2026-05-22

faculty

23 h-index 66 pubs 2,835 cited

Research Areas

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

Hui-Ming Chang, a Professor at the University of Arkansas for Medical Sciences, leads a research group investigating complex biological pathways. Their work has been recognized with a high-impact researcher designation and federal grant principal investigator status. Chang's recent publications explore diverse areas including the regulation of signaling pathways, such as the TRAF6/sNASP axis by reversible phosphorylation, and the role of Dipeptidylpeptidase 4 in acute myeloid leukemia stem cell survival.

Further research interests include the neural mechanisms underlying hypertension and stress, with studies examining Kv7 channel activity in the central amygdala and the role of corticotropin-releasing hormone neurons. Additionally, Chang's group investigates the impact of chemotherapy on cognitive function, specifically the contribution of microglia-mediated synaptic dysfunction, and the protective effects of dexrazoxane in preventing doxorubicin-induced heart failure. Collaborations with Edward T.H. Yeh and J.C. Hsu at the University of Arkansas for Medical Sciences have resulted in shared publications, highlighting a network of ongoing research endeavors.

Metrics

h-index: 23
Publications: 66
Citations: 2,835

Selected Publications

PP4 modulates macrophage-neutrophil crosstalk to restrict CCL5 -driven NETosis in sepsis (2026)

DOI OpenAlex
Microglia‐Mediated Synaptic Dysfunction Contributes to Chemotherapy‐Related Cognitive Impairment (2025)

3 citations DOI OpenAlex
Abstract 12348: Targeted Degradation of Topoisomerase 2b by Dexrazoxane for Prevention of Doxorubicin-Induced Cardiotoxicity: Dose and Time Course Study in Human (2023)

1 citation DOI OpenAlex
Corticotropin-releasing hormone neurons in the central nucleus of amygdala are required for chronic stress-induced hypertension (2023)

18 citations DOI OpenAlex
Dipeptidylpeptidase 4 promotes survival and stemness of acute myeloid leukemia stem cells (2023)

11 citations DOI OpenAlex
Signaling pathways involved in <scp>NMDA</scp>‐induced suppression of M‐channels in corticotropin‐releasing hormone neurons in central amygdala (2022)

6 citations DOI OpenAlex
Dependence of Acute Myeloid Leukemia Development on Membrane Protein Dipeptidyl Peptidase 4 (2022)

DOI OpenAlex
Abstract 9710: Prevention of Doxorubicin-Induced Cardiotoxicity Through Targeted Degradation of Topoisomerase 2b (2021)

DOI OpenAlex
Regulation of TLR4 signaling through the TRAF6/sNASP axis by reversible phosphorylation mediated by CK2 and PP4 (2021)

13 citations DOI OpenAlex
Impaired Kv7 channel activity in the central amygdala contributes to elevated sympathetic outflow in hypertension (2021)

23 citations DOI OpenAlex