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John C. Marecki Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Instructor

University of Arkansas for Medical Sciences

faculty

Biochemistry & Molecular Biology, College of Medicine

18 h-index 40 pubs 1,840 cited

Research Areas

RNA helicases and viral replication Biomolecular condensates in replication Protein structure and dynamics Microbial infections and disease research Molecular Biology Techniques and Applications RNA Research and Splicing

Links

ORCID Research Group UAMS TRI Profile

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OverviewAI-generated summary

John C. Marecki's research centers on molecular mechanisms governing viral replication and RNA processing. His work investigates the role of RNA helicases in viral propagation, examining how these enzymes interact with nucleic acids like G-quadruplex DNA and double-stranded DNA. Marecki's publications explore the structural features of helicases that influence their unwinding activity and their involvement in biomolecular condensates, which play a role in viral replication. He has also contributed to understanding the functional dynamics of viral polymerases, including post-assembly conformational changes that enable elongation. His research network includes collaborators such as Emory G. Malone, Wayne P. Wahls, and Reine U. Protacio from the University of Arkansas for Medical Sciences. Marecki's scholarship metrics include an h-index of 18 and over 1,800 citations across 40 publications.

Metrics

  • h-index: 18
  • Publications: 40
  • Citations: 1,840

Selected Publications

  • Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2025) DOI
  • A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025) DOI
  • Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2025) DOI
  • RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2025) DOI
  • A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025) DOI
  • Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2024) DOI
  • Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024) DOI
  • Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024) DOI
  • RNA helicases required for viral propagation in humans (2021) DOI
  • A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp> (2021) DOI
  • G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p (2021) DOI

Grants & Funding

  • Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids NIH Co-Investigator
  • Mechanisms of Protection and Pathogenesis in ALS Mice NIH/Nat. Inst. of Neurological Disorders & Stroke Co-Investigator
  • Coronavirus Genome Replication Subcontract UNC-CH Craig Cameron NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: University of North Carolina - Chapel Hill Principal Investigator
  • Midwest AViDD Center NIH/Nat. Inst. of Allergy & Infectious Diseases - Pass Through: University of Minnesota Principal Investigator
  • Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator

Collaborators

Researchers in the database who share publications

Emory G. Malone University of Arkansas for Medical Sciences 2 shared publications Wayne P. Wahls University of Arkansas for Medical Sciences 2 shared publications Reine U. Protacio University of Arkansas for Medical Sciences 2 shared publications A. Edwards University of Arkansas for Medical Sciences 1 shared publication Maroof Zafar University of Arkansas for Medical Sciences 1 shared publication Matthew D. Thompson Lyon College 1 shared publication Lindsey Hazeslip University of Arkansas for Medical Sciences 1 shared publication Binyam Belachew University of Arkansas for Medical Sciences 1 shared publication

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