John C. Marecki

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

Instructor

University of Arkansas UAMS primary

Also affiliated: Johns Hopkins University (2006–2007); Johns Hopkins Medicine (2007); Allegheny General Hospital (2006); University of Colorado Health (1993–2006); Pulmonary Associates (2005); Arkansas Children's Nutrition Center (2007–2013); Webb Institute (1993); University of California, Davis (2005); University of Colorado Denver (2006)

Faculty Researcher

Biochemistry & Molecular Biology, College of Medicine

18 h-index 44 pubs 1,888 cited

Research Areas

Biomedical Subjects

Links

ORCID Research Group UAMS TRI Profile

OverviewAI-generated summary

John C. Marecki's research investigates the function of RNA helicases, enzymes crucial for viral propagation in humans. His work explores how these helicases interact with nucleic acids, specifically focusing on G-quadruplex DNA, which can inhibit their unwinding activity while promoting liquid-liquid phase separation. Marecki has also studied the structural features of helicases that influence their DNA-binding and displacement capabilities.

His recent publications examine the coupling of RNA polymerase and helicase in viral replication, enabling rapid elongation through duplex RNA. He has also investigated the role of biomolecular condensates in controlling and defining RNA-RNA interactions during viral replication. Marecki's scholarship is supported by a publication record contributing to an h-index of 18 and over 1,800 citations, with key collaborations at the University of Arkansas for Medical Sciences.

Metrics

h-index: 18
Publications: 44
Citations: 1,888

Selected Publications

The nucleoside analog CMX521 inhibits coronavirus RNA-dependent RNA polymerase via a two-pronged mechanism (2026)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
Copy-back RNA synthesis by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2026)

Science Advances DOI OpenAlex
Abstract 5612 The UAMS Center for Molecular Interactions in Cancer (CMIC) Biomolecular Interactions Core (BIC) (2026)

Journal of Biological Chemistry DOI OpenAlex
RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2026)

Cell Reports DOI OpenAlex
Template switching by coronavirus polymerase requires helicase activity and is stimulated by remdesivir and molnupiravir (2025)

bioRxiv (Cold Spring Harbor Laboratory) DOI OpenAlex
A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025)

Nucleic Acids Research 4 citations DOI OpenAlex
Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2025)

Research Square 1 citation DOI OpenAlex
RNA virus polymerase-helicase coupling enables rapid elongation through duplex RNA (2025)

bioRxiv (Cold Spring Harbor Laboratory) 2 citations DOI OpenAlex
A post-assembly conformational change makes the SARS-CoV-2 polymerase elongation-competent (2025)

bioRxiv (Cold Spring Harbor Laboratory) 1 citation DOI OpenAlex
Biomolecular condensates control and are defined by RNA-RNA interactions that arise in viral replication (2024)

bioRxiv (Cold Spring Harbor Laboratory) 6 citations DOI OpenAlex
Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)

Nature Communications 9 citations DOI OpenAlex
Two residues in the DNA binding site of Pif1 helicase are essential for nuclear functions but dispensable for mitochondrial respiratory growth (2024)

Nucleic Acids Research 2 citations DOI OpenAlex
RNA helicases required for viral propagation in humans (2021)

The Enzymes 23 citations DOI OpenAlex
A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp> (2021)

Protein Science 8 citations DOI OpenAlex
G-quadruplex DNA inhibits unwinding activity but promotes liquid–liquid phase separation by the DEAD-box helicase Ded1p (2021)

Chemical Communications 12 citations DOI OpenAlex

View all publications on OpenAlex →

Grants & Funding

As listed on this researcher's institutional profile.

Functions and Mechanisms of Helicases and G-Quadruplex Nucleic Acids NIH Co-Investigator
Mechanisms of Protection and Pathogenesis in ALS Mice NIH/Nat. Inst. of Neurological Disorders & Stroke Co-Investigator
Coronavirus Genome Replication Subcontract UNC-CH Craig Cameron NIH/Nat. Inst. of Allergy & Infectious Diseases via University of North Carolina - Chapel Hill Principal Investigator
Midwest AViDD Center NIH/Nat. Inst. of Allergy & Infectious Diseases via University of Minnesota Principal Investigator
Center for Molecular Interactions in Cancer (CMIC) NIH Co-Investigator