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Current · Arkansas
Last published
2025
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OpenAlex · ORCID
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2026-10-06
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Volodymyr Tryndyak
Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.
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Also affiliated: University of Lethbridge (2008); Roswell Park Comprehensive Cancer Center (2008); National Institutes of Health (2008); United States Food and Drug Administration (2007–2025); National Academy of Sciences of Ukraine (2005); R.E. Kavetsky Institute of Experimental Pathology, Oncology and Radiobiology (2002–2013); National Cancer Institute (2008); Centre international de recherche sur le cancer (2023); University of Tennessee at Knoxville (2006)
44 h-index
158 pubs
7,008 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Volodymyr Tryndyak's research investigates the molecular mechanisms underlying disease development, with a particular focus on epigenetics and microRNA regulation in cancer and metabolic disorders. He has explored the role of microRNAs in the development of resistance to chemotherapy in breast cancer cells, examining alterations in microRNA expression in relation to drug resistance and the epithelial-mesenchymal transition. His work also delves into the epigenetic mechanisms that influence susceptibility to diet-induced nonalcoholic steatohepatitis (NASH) in mice, identifying specific microRNAs associated with strain-specific susceptibility to the condition.
Further investigations by Tryndyak have examined the carcinogenicity of per- and polyfluoroalkyl substances (PFAS), such as perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS). His research has also touched upon the role of epigenetic effectors in maintaining long-term biological effects and alterations in ferritin in human breast cancer cells. With a career marked by extensive publication and high citation counts (h-index: 44, total citations: 6,783), Tryndyak has a history of collaboration with researchers at the National Center for Toxicological Research, including Igor P. Pogribny and Frederick A. Beland.
Metrics
- h-index: 44
- Publications: 158
- Citations: 7,008
Selected Publications
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Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025)
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Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025)
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Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic (2025)
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A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024)
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Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023)
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Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023)
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Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023)
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Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023)
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Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023)
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Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas (2022)
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Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022)
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Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022)
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Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets (2022)
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Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021)
Collaboration Network
Top Collaborators
Igor P. Pogribny
National Center for Toxicological Research
94 shared publications
In database
- Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
- Role of ferritin alterations in human breast cancer cells
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
Showing 5 of 94 shared publications
Frederick A. Beland
National Center for Toxicological Research
70 shared publications
In database
- E‐cadherin transcriptional down‐regulation by epigenetic and microRNA‐200 family alterations is related to mesenchymal and drug‐resistant phenotypes in human breast cancer cells
- Role of ferritin alterations in human breast cancer cells
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Down‐regulation of the microRNAs miR‐34a, miR‐127, and miR‐200b in rat liver during hepatocarcinogenesis induced by a methyl‐deficient diet
Showing 5 of 70 shared publications
Ivan Rusyn
Texas A&M University (US)
29 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Methyl Deficiency, Alterations in Global Histone Modifications, and Carcinogenesis
- Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
- Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
Showing 5 of 29 shared publications
Aline de Conti
National Center for Toxicological Research (US)
26 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Effect of methionine‐deficient and methionine‐supplemented diets on the hepatic one‐carbon and lipid metabolism in mice
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
Showing 5 of 26 shared publications
Sharon A. Ross
National Cancer Institute (US)
18 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Difference in expression of hepatic microRNAs miR-29c, miR-34a, miR-155, and miR-200b is associated with strain-specific susceptibility to dietary nonalcoholic steatohepatitis in mice
- Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
- Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats
- Down‐regulation of the microRNAs miR‐34a, miR‐127, and miR‐200b in rat liver during hepatocarcinogenesis induced by a methyl‐deficient diet
Showing 5 of 18 shared publications
Levan Muskhelishvili
National Center for Toxicological Research (US)
14 shared publications
- Methyl Deficiency, Alterations in Global Histone Modifications, and Carcinogenesis
- Coupling global methylation and gene expression profiles reveal key pathophysiological events in liver injury induced by a methyl‐deficient diet
- The tumor-promoting activity of 2-acetylaminofluorene is associated with disruption of the p53 signaling pathway and the balance between apoptosis and cell proliferation☆
- Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
- Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis
Showing 5 of 14 shared publications
Svitlana Shpyleva
Arkansas Children's Hospital
13 shared publications
In database
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Role of ferritin alterations in human breast cancer cells
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
Showing 5 of 13 shared publications
Olga Kovalchuk
University of Lethbridge (CA)
13 shared publications
- Involvement of microRNA-451 in resistance of the MCF-7 breast cancer cells to chemotherapeutic drug doxorubicin
- Alterations of microRNAs and their targets are associated with acquired resistance of MCF‐7 breast cancer cells to cisplatin
- Role of ferritin alterations in human breast cancer cells
- Role of epigenetic effectors in maintenance of the long-term persistent bystander effect in spleen in vivo
- Fractionated Low-Dose Radiation Exposure Leads to Accumulation of DNA Damage and Profound Alterations in DNA and Histone Methylation in the Murine Thymus
Showing 5 of 13 shared publications
Stepan Melnyk
Arkansas Children's Hospital
10 shared publications
In database
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Epigenetic alterations in the brains of Fisher 344 rats induced by long-term administration of folate/methyl-deficient diet
- Cerebellar Oxidative DNA Damage and Altered DNA Methylation in the BTBR T+tf/J Mouse Model of Autism and Similarities with Human Post Mortem Cerebellum
- Effect of methionine‐deficient and methionine‐supplemented diets on the hepatic one‐carbon and lipid metabolism in mice
- Interstrain differences in liver injury and one-carbon metabolism in alcohol-fed mice
Showing 5 of 10 shared publications
Kostiantyn Dreval
Simon Fraser University (CA)
10 shared publications
- Multiple microRNAs function as self-protective modules in acetaminophen-induced hepatotoxicity in humans
- MicroRNA deregulation in nonalcoholic steatohepatitis-associated liver carcinogenesis
- Quantitative comparison of in vitro genotoxicity between metabolically competent HepaRG cells and HepG2 cells using the high-throughput high-content CometChip assay
- Inhibition of the Cell Death Pathway in Nonalcoholic Steatohepatitis (NASH)-Related Hepatocarcinogenesis Is Associated with Histone H4 lysine 16 Deacetylation
- Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells
Showing 5 of 10 shared publications
Rose Willett
National Center for Toxicological Research
9 shared publications
In database
- Characterization of the variability in the extent of nonalcoholic fatty liver induced by a high‐fat diet in the genetically diverse Collaborative Cross mouse model
- Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet
- Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice
- Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice
- A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice
Showing 5 of 9 shared publications
Marta Pogribna
National Center for Toxicological Research
8 shared publications
In database
- Irreversible global DNA hypomethylation as a key step in hepatocarcinogenesis induced by dietary methyl deficiency
- Histone H3 lysine 9 and H4 lysine 20 trimethylation and the expression of Suv4-20h2 and Suv-39h1 histone methyltransferases in hepatocarcinogenesis induced by methyl deficiency in rats
- Modifying metabolically sensitive histone marks by inhibiting glutamine metabolism affects gene expression and alters cancer cell phenotype
- Modulation of intracellular iron metabolism by iron chelation affects chromatin remodeling proteins and corresponding epigenetic modifications in breast cancer cells and increases their sensitivity to chemotherapeutic agents
- Strain‐dependent dysregulation of one‐carbon metabolism in male mice is associated with choline‐ and folate‐deficient diet‐induced liver injury
Showing 5 of 8 shared publications
John R. Latendresse
National Center for Toxicological Research (US)
8 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression
- Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
- Interstrain differences in the severity of liver injury induced by a choline‐ and folate‐deficient diet in mice are associated with dysregulation of genes involved in lipid metabolism
- Epigenetic Alterations in Liver of C57BL/6J Mice after Short-Term Inhalational Exposure to 1,3-Butadiene
Showing 5 of 8 shared publications
Beverly Montgomery
National Center for Toxicological Research (US)
7 shared publications
- Hepatic epigenetic phenotype predetermines individual susceptibility to hepatic steatosis in mice fed a lipogenic methyl-deficient diet
- Estrogen-Induced Rat Breast Carcinogenesis is Characterized by Alterations in DNA Methylation, Histone Modifications, and Aberrant microRNA Expression
- Plasma microRNAs are sensitive indicators of inter-strain differences in the severity of liver injury induced in mice by a choline- and folate-deficient diet
- Mechanisms of peroxisome proliferator-induced DNA hypomethylation in rat liver
- Epigenetic reprogramming of liver cells in tamoxifen‐induced rat hepatocarcinogenesis
Showing 5 of 7 shared publications
Iryna Kindrat
National Center for Toxicological Research (US)
7 shared publications
- MicroRNA-152-mediated dysregulation of hepatic transferrin receptor 1 in liver carcinogenesis
- Effect of aflatoxin B1, benzo[a]pyrene, and methapyrilene on transcriptomic and epigenetic alterations in human liver HepaRG cells
- Epigenetically mediated inhibition of S‐adenosylhomocysteine hydrolase and the associated dysregulation of 1‐carbon metabolism in nonalcoholic steatohepatitis and hepatocellular carcinoma
- Cellular and Molecular Effects of Prolonged Low-Level Sodium Arsenite Exposure on Human Hepatic HepaRG Cells
- Effect of methapyrilene hydrochloride on hepatic intracellular iron metabolism in vivo and in vitro
Showing 5 of 7 shared publications
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