Volodymyr Tryndyak Source Confirmed

Affiliation confirmed via AI analysis of OpenAlex, ORCID, and web sources.

High Impact

Researcher

National Center for Toxicological Research

faculty

44 h-index 156 pubs 6,564 cited

Research Areas

Carcinogens and Genotoxicity Assessment Pharmacological Effects and Toxicity Studies Diet and metabolism studies Epigenetics and DNA Methylation SARS-CoV-2 and COVID-19 Research Metabolomics and Mass Spectrometry Studies Liver Disease Diagnosis and Treatment Cancer-related molecular mechanisms research

Links

ORCID

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OverviewAI-generated summary

Volodymyr Tryndyak's research focuses on evaluating the toxicological effects of various chemical compounds and environmental factors on biological systems. He investigates mechanisms of toxicity, including genotoxicity, carcinogenicity, and epigenetic alterations, often employing studies in cell cultures and animal models. His work has examined the impacts of per- and polyfluoroalkyl substances (PFAS) like perfluorooctanoic acid and perfluorooctanesulfonic acid, as well as inorganic arsenic and black cohosh extract.

Tryndyak also studies the effects of diet on health, specifically examining how high-fat, high-sucrose diets influence non-alcoholic fatty liver disease (NAFLD) and associated epigenetic changes in genetically diverse mouse models. His research includes lipidomic profiling and gene expression analyses to understand the molecular underpinnings of these conditions. Additionally, he has contributed to research on the detection of SARS-CoV-2 variants in wastewater, indicating an interest in environmental monitoring for public health.

With a h-index of 44 and over 6,500 citations across 156 publications, Tryndyak is recognized as a highly cited researcher. His collaborations include significant joint publications with colleagues at the National Center for Toxicological Research, such as Igor P. Pogribny and Frederick A. Beland.

Metrics

h-index: 44
Publications: 156
Citations: 6,564

Selected Publications

Mediation analysis of the molecular phenotypes in a severe MASH-like liver injury mouse model (2025) DOI
Signature gene expression model for quantitative evaluation of MASH-like liver injury in mice (2025) DOI
Wastewater dataset on the SARS-CoV-2 sublineages circulating in Central Arkansas, USA, post-COVID-19 pandemic (2025) DOI
A preclinical model of severe NASH-like liver injury by chronic administration of a high-fat and high-sucrose diet in mice (2024) DOI
Cellular and molecular alterations in a human hepatocellular in vitro model of nonalcoholic fatty liver disease development and stratification (2023) DOI
Evaluating the toxicokinetics of some metabolites of a C6 polyfluorinated compound, 6:2 fluorotelomer alcohol in pregnant and nonpregnant rats after oral exposure to the parent compound (2023) DOI
Gene expression analyses reveal potential mechanism of inorganic arsenic‐induced apoptosis in zebrafish (2023) DOI
Abstract 6017: Exposure-related DNA methylation and gene expression changes in mammary glands of Sprague Dawley rats treated with lorcaserin (2023) DOI
Effect of an obesogenic high-fat and high-sucrose diet on hepatic gene expression signatures in male Collaborative Cross mice (2023) DOI
Temporal dynamics of SARS-CoV-2 genome and detection of variants of concern in wastewater influent from two metropolitan areas in Arkansas (2022) DOI
Lipidomic profiling of the hepatic esterified fatty acid composition in diet-induced nonalcoholic fatty liver disease in genetically diverse Collaborative Cross mice (2022) DOI
Non-alcoholic fatty liver disease-associated DNA methylation and gene expression alterations in the livers of Collaborative Cross mice fed an obesogenic high-fat and high-sucrose diet (2022) DOI
Epigenetic changes induced in mice liver by methionine-supplemented and methionine-deficient diets (2022) DOI
Mechanistic Evaluation of Black Cohosh Extract-Induced Genotoxicity in Human Cells (2021) DOI