Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Emory G. Malone's research focuses on the function and regulation of DNA helicases, particularly the Pif1 family. Their work investigates how these enzymes interact with DNA structures like G-quadruplexes and double-stranded DNA, utilizing conserved mechanisms to unwind them. Malone has also studied the structural features of viral helicases, such as the Dda helicase from bacteriophage T4, and their ability to displace proteins from DNA. Further research includes examining genome editing efficiency and the creation of unintended genetic alterations using CRISPR/Cas9 in model organisms like *Schizosaccharomyces pombe*. Additionally, Malone has investigated factors affecting microbial growth, including yeast spore plating efficiency and transcription factor activation of meiotic recombination hotspots.
Metrics
- h-index: 3
- Publications: 8
- Citations: 35
Positions
-
Graduate Research Assistant 2023–presentUniversity of Arkansas for Medical Sciences Biochemistry and Molecular Biology ORCID
-
Research Technician 2021–2022University of Arkansas for Medical Sciences Biochemistry and Molecular Biology ORCID
Selected Publications
-
Abstract 3871 Transcription factor Toe2 activates the meiotic recombination hotspot 4156 (2026)
-
Agar lot-specific inhibition in the plating efficiency of yeast spores and cells (2024)
-
Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles (2024)
-
Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)
-
DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe (2024)
-
Role and Regulation of Pif1 Family Helicases at the Replication Fork (2022)
-
Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously (2022)
-
A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA (2021)
Collaboration Network
Top Collaborators
- Role and Regulation of Pif1 Family Helicases at the Replication Fork
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles
- Agar lot-specific inhibition in the plating efficiency of yeast spores and cells
- DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe
- Role and Regulation of Pif1 Family Helicases at the Replication Fork
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles
- DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- A structural feature of Dda helicase which enhances displacement of streptavidin and trp repressor from DNA
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
Similar Researchers
Based on overlapping research topics