Emory G. Malone
Graduate Research Assistant
Graduate Student Researcher
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Emory G. Malone's research focuses on the molecular mechanisms of DNA processing and genome stability, with a particular emphasis on helicase function and DNA replication. Malone has investigated the role and regulation of Pif1 family helicases at the replication fork and their ability to unwind G-quadruplex and double-stranded DNA. Research also includes examining structural features of helicases, such as the Dda helicase, that influence their interaction with DNA-bound molecules. Additionally, Malone has explored aspects of genome editing, including distance-dependent effects of CRISPR/Cas9 in *Schizosaccharomyces pombe* and the genetic basis of specific alleles in this organism. The work also touches upon yeast genetics, investigating factors that affect spore and cell plating efficiency and the activation of meiotic recombination hotspots.
Metrics
- h-index: 3
- Publications: 7
- Citations: 34
Selected Publications
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Abstract 3871 Transcription factor Toe2 activates the meiotic recombination hotspot 4156 (2026)
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Agar lot-specific inhibition in the plating efficiency of yeast spores and cells (2024)
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Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles (2024)
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Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge (2024)
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DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe (2024)
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Role and Regulation of Pif1 Family Helicases at the Replication Fork (2022)
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Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously (2022)
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A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp> (2021)
Collaboration Network
Top Collaborators
- Role and Regulation of Pif1 Family Helicases at the Replication Fork
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles
- Agar lot-specific inhibition in the plating efficiency of yeast spores and cells
- DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe
- Role and Regulation of Pif1 Family Helicases at the Replication Fork
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Monitoring helicase-catalyzed unwinding of multiple duplexes simultaneously
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Distance-dependent effects on CRISPR/Cas9-mediated genome editing in Schizosaccharomyces pombe compromise efficiency and create unsought alleles
- DNA sequences and distinct mechanisms for ura4-595 and ura4-294 alleles of S. pombe
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Agar lot-specific inhibition in the plating efficiency of yeast spores and cells
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- A structural feature of Dda helicase which enhances displacement of streptavidin and <i>trp</i> repressor from <scp>DNA</scp>
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
- Eukaryotic Pif1 helicase unwinds G-quadruplex and dsDNA using a conserved wedge
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