Japneet Kaur

Postdoctoral fellow

University of Arkansas for Medical Sciences

postdoc

JKaur4@uams.edu

14 h-index 104 pubs 575 cited

Research Areas

Bone Metabolism and Diseases Cellular Senescence and Aging MicroRNA in disease regulation Cancer-related molecular mechanisms research Osteoporosis research Health and Medical Research Impacts Molecular Biology Techniques and Applications

Links

ORCID Lab Website

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OverviewAI-generated summary

Japneet Kaur's research investigates cellular senescence, a process linked to aging and various age-related diseases, with a particular focus on its role in bone health and disease. Her work has explored the effects of senolytic therapies, which aim to clear senescent cells, in aged mice, examining how local versus systemic application impacts skeletal tissues. Kaur has also studied the in vitro and in vivo effects of zoledronic acid, a bisphosphonate drug, on senescence markers and the senescence-associated secretory phenotype (SASP).

Her publications also delve into the molecular mechanisms underlying aging and disease, including the role of microRNAs in bone aging and the Nrf2 pathway in psychiatric disorders. Kaur has investigated the impact of diabetes on osteocytes, the bone-lining cells within the mineralized bone matrix. Furthermore, her research has employed single-cell transcriptomic analysis to identify senescent osteocytes that contribute to bone destruction in the context of breast cancer metastasis. Kaur has published over 100 papers and holds an h-index of 14, with her work being cited more than 575 times. She is a Co-PI on a $395,650 NIH grant focused on developing a biomarker assay for delayed radiation injury.

Metrics

  • h-index: 14
  • Publications: 104
  • Citations: 575

Selected Publications

  • Healing of lytic lesions and restoration of bone health in multiple myeloma through sclerostin inhibition (2025) DOI
  • Ex Vivo Model Systems of Cancer-Bone Cell Interactions (2025) DOI
  • A novel CCL3-HMGB1 signaling axis regulating osteocyte RANKL expression in multiple myeloma (2024) DOI
  • Senolytics deplete senescent osteocytes and improve bone health in metastatic breast cancer (2024) DOI
  • Single-cell Transcriptome Analysis Identifies Senescent Osteocytes as Contributors to Bone Destruction in Breast Cancer Metastasis (2024) DOI
  • A NOTCH3-CXCL12-driven myeloma-tumor niche signaling axis promotes chemoresistance in multiple myeloma (2024) DOI

Federal Grants 1 $395,650 total

NIH/NIH Office of the Director Co-PI Feb 2020 - Jan 2026

Development of a minimally invasive biomarker assay to detect delayed radiation injury

NIH Office of the Director $395,650 U01

Collaborators

Researchers in the database who share publications

Hayley M. Sabol University of Arkansas for Medical Sciences 31 shared publications Elena Ambrogini University of Arkansas for Medical Sciences 31 shared publications Aric Anloague University of Arkansas for Medical Sciences 31 shared publications Olivia Reyes‐Castro University of Arkansas for Medical Sciences 28 shared publications Charles A. O’Brien University of Arkansas for Medical Sciences 26 shared publications Maria Almeida University of Arkansas for Medical Sciences 22 shared publications Jesús Delgado‐Calle University of Arkansas for Medical Sciences 14 shared publications Intawat Nookaew University of Arkansas for Medical Sciences 3 shared publications

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