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Listed
Presence
Current · Arkansas
Last published
2026
Sources
OpenAlex · ORCID
Refreshed
2026-10-05
E
Esraa Shosha
Assistant Professor
Also affiliated: Cairo University (2019–2026); Augusta University (2014–2022); University of Arkansas Medical Center (2024); Charlie Norwood VA Medical Center (2016–2021); Veterans Health Administration (2016)
COM | Pharmacology Channel & Hypertension
15 h-index
40 pubs
701 cited
Research Areas
Biomedical Subjects
Links
Biography and Research Information
OverviewAI-generated summary
Esraa Shosha investigates the molecular mechanisms underlying retinal diseases, particularly those related to ischemia/reperfusion injury and diabetic retinopathy. Her research focuses on the role of arginase enzymes (Arginase 1 and Arginase 2) in promoting or protecting against neurovascular degeneration in the retina. Shosha has explored how Arginase 1 suppresses inflammatory responses in macrophages and limits neovascularization, while Arginase 2 has been shown to mediate injury by inducing mitochondrial dysfunction and promoting degeneration. Additionally, her work examines other potential therapeutic targets, such as spermine oxidase, for neurodegeneration in diabetic retinopathy. Her publications also address the role of myeloid cells in ischemic retinopathies. Shosha's work has been supported by funding for her research endeavors, and she collaborates with researchers at the University of Arkansas for Medical Sciences, including Abdelrahman Y. Fouda, Carol Morris, and Nancy J. Rusch.
Metrics
- h-index: 15
- Publications: 40
- Citations: 701
Positions
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University of Arkansas for Medical Sciences 2022–presentPharmacology and Toxicology ORCID
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Assistant Professor publications 2022–2026University of Arkansas for Medical Sciences COM | Pharmacology Channel & Hypertension Institutional directory
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Postdoctoral Fellow 2018–2021Augusta University Vascular Biology Center ORCID
Selected Publications
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Temporal and Age-Dependent Regulation of Phagocytosis-Related Signatures After Ischemic Stroke: Cross-Species Transcriptomic Evidence (2026)
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CD5L promotes efferocytosis and resolution of retinal ischemic injury (2026)
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A metabolic switch in retinal angiogenesis: Histone deacetylase 3 (2026)
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Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025)
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HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis (2025)
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Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy (2025)
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HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164) (2025)
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Disrupting the CD47/SIRPα Axis as a Novel and Translational Therapy for Stroke (Abstract ID: 161422) (2025)
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Efferocytosis and retinal clean-up: Role of histone deacetylase 3 in ischemic retinopathy (2025)
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Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology (2024)
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Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury (2024)
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Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions (2024)
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The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury (2023)
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Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair (2022)
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Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice (2022)
Grants & Funding
As listed on this researcher's institutional profile.
- Role of endothelial HDAC3 in proliferative retinopathy American Heart Association Principal Investigator
Collaboration Network
Top Collaborators
Abdelrahman Y. Fouda
Cairo University
15 shared publications
In database
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
Showing 5 of 15 shared publications
Carol Morris
University of Arkansas for Medical Sciences
6 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
Showing 5 of 6 shared publications
Rami Ahmad Shahror
University of Arkansas for Medical Sciences
5 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- Temporal and Age-Dependent Regulation of Phagocytosis-Related Signatures After Ischemic Stroke: Cross-Species Transcriptomic Evidence
Nancy J. Rusch
University of Arkansas for Medical Sciences
5 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
- CD5L promotes efferocytosis and resolution of retinal ischemic injury
Melissa Wild
University of Arkansas for Medical Sciences
5 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Deletion of myeloid HDAC3 promotes efferocytosis to ameliorate retinal ischemic injury
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
- CD5L promotes efferocytosis and resolution of retinal ischemic injury
Ruth B. Caldwell
Augusta University (US)
4 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
Christian D. Mitchell
University of Arkansas for Medical Sciences
4 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
- HDAC3 Drives Retinal Endothelial Cell Angiogenesis: Potential Therapeutic Implications for Retinopathy (Abstract ID: 161164)
Zhimin Xu
Augusta University (US)
3 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
- The arginase 1/ornithine decarboxylase pathway suppresses HDAC3 to ameliorate the myeloid cell inflammatory response: implications for retinal ischemic injury
Bushra Zaman
University of Arkansas for Medical Sciences
3 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- CD5L promotes efferocytosis and resolution of retinal ischemic injury
Ahmed B. Sallam
Ain Shams University
3 shared publications
In database
- Proteomic Analysis of Aqueous Humor in Central Retinal Artery Occlusion: Unveiling Novel Insights Into Disease Pathophysiology
- Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy
- Systemic Lactate Dehydrogenase Levels as a Predictor of Progression from Non-Proliferative to Proliferative Diabetic Retinopathy
Tahira Lemtalsi
Augusta University (US)
2 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Syed Zaidi
Augusta University (US)
2 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Modesto Rojas
Augusta University (US)
2 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Robert W. Caldwell
Augusta University (US)
2 shared publications
- Targeting proliferative retinopathy: Arginase 1 limits vitreoretinal neovascularization and promotes angiogenic repair
- Investigation of Retinal Metabolic Function in Type 1 Diabetic Akita Mice
Aya A Mohammed
University of Arkansas for Medical Sciences
2 shared publications
In database
- Role of myeloid cells in ischemic retinopathies: recent advances and unanswered questions
- HDAC3 mediates retinal endothelial cell metabolic reprogramming and angiogenesis
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